Background &Aims : The effect endurance exercises on hypothalamus are not clear. Exercise is a powerful stimulus for the endocrine system and depends on several factors, ie: duration, intensity and the mode of exercise and training status.

  Materials & Methods : One hundred and thirty volunteered runner men entered to this project but 16 men selected randomly. Excluding from this project were diabeties, cardiovascular and other endocrine problems. Blood samples from runner were obtained in fasting, 30 minutes after running exercise (endurance versus resistance) and 3 hour after resting.

 Results: Serum samples were separated and stored at -40 ⁰C until to be tested. Serum prolactin, testosterone and DHEA-S levels were measured by chemiluminescence automathed systems and results compaired by known standard curve. Statistical analysis carried out by SPss and Paired – Sample Test. All results below 0.05 P value (P < 0.05) considered to be significant. Prolactin and DHEA-S levels increased and testosterone level decreased after 30 minutes running (P < 0.05). But did not change after three hours resting.

 Conclusion: Our investigation show running up to 30 minutes as a endurance condition could increase serum DHEA-S and prolactin levels and decrease in serum testosterone level but they decrease to about fasting condition after three hours resting.

 Address: Urmia University, Faculty of Medicine, Biochemistry, Tel:(+98) 09141415879

 Email : mhansari1@gmail.com

  Source : Urmia Med J 2011: 21(5):451 ISSN: 1027-3727

  Background & Aims: Prescription of the atypical antipsychotic drugs like as Sulpiride for the treatment of schizophrenic patients was increased because of their less side effects. This study was aimed to evaluate the effect of sulpiride on serum level of prolactin and sexual hormones.

  Materials & Methods: Twenty three adult male mice were divided in three groups as test, control sham and control. The test mice were received sulpiride solution, daily for 45 days IP. Mice in the control sham were received the solvent only. Sample blood gathered and level of prolactin, LH, FSH and testosterone were measured in the serum samples of all 3 groups and data was analyzed.

  Results: A significant increase in serum prolactin levels was found in the treated mice which were along with a significant decrease of LH, FSH and testosterone levels.

  Conclusion : These findings indicate that sulpiride is able to induce prolactin reproductive dysfunctions that by this induce and increase in proluctin level can control sexual hormones and disorder normal functioning of the reproductivity.

  SOURCE: URMIA MED J 2013: 23(6): 706 ISSN: 1027-3727