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  Background & Aims : Cholecystectomy is a most known procedure in patients with gallbladder disease such as choleducolithiasis. This study aimed to study the effect of ampibactam prophylaxy (ampicillin/sulbactam) on the low-risk patients who were candidates for elective laparoscopic cholecystectomy.

  Materials & Methods: This clinical double blind work study was evaluating the elective laparoscopic cholecystectomy in 160 low-risk patients with choleducolithiasis with informed consent 2010-11. The patients were randomly divided into two groups including group A as study group that received 3gr dose of ampibactam (Jaber-ebne-Hayyan Inc) intravenously and group B as the control group that received 10cc normal saline (N/S). The information about age, sex, weight, body mass index (BMI), routine tests, hospital stay for all patients was collected. The patients during hospitalization and within 30 days after surgery were followed for incidence of infectious complications.

  Results: According to this study, 1 patient (2.1%) of the intervention group and 2 patients (5.2%) in the control group were infected with the Fisher exact test showed no significant differences between the two groups, and the incidence of infection (P=4.0). In all three cases (9.1%) had an infection in one patient (6.0%) from the intervention group and 2 patients (3.1%) of the control patients had a skin wound infection (P=5.0). (P= 8.0). The infection complications have seen in one pationet in control group after 6 and in 2 patients of study group after 5 day after cholecystectom. The mean duration of hospitalization after cholecystectomy in 80 patients in the intervention group was 2.08 ± 0.28 days versus 2.17 ± 0.4 d in the control group (P=1.0).

  Conclusion : This study results such as other studies results, don’t demonstrate the efficiency of prophylactic antibiotics in low-risk laparoscopic cholecystectomy. So preferably it's not recommended to prescribe antibiotics in low-risk laparoscopic cholecystectomy conditions.

 

   

  SOURCE: URMIA MED J 2013: 23(6): 702 ISSN: 1027-3727

 

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Background & Aims: The presence of resistant bacteria in different parts of hospitals and the problems these persistent bacteria cause in treating the patients urge the necessity of identification and precise knowledge about these bacteria and their sensitivity pattern and resistance against antibiotics. This investigation was conducted in order to determine the sensitivity pattern and resistance against antibiotics in isolated microorganisms from hospitalized patients. Materials & Methods: This is a descriptive sectional investigation which was conducted from January 2009 to January 2011 in Taleghani Hospital in Urmia City and the cultured samples of patients from different parts of the hospital including urine, blood, phlegm, ulcer, discharge, etc. sent to the laboratory were investigated. In order to determine antibiogram disk agar diffusion (DAD) method was used, positive cultures were extracted and their results regarding the type of bacteria and antibiogram results were recorded in the experiment paper. The gathered data were analyzed using SPSS-20 software. Results: From all cultured samples in two years, 964 samples were reported and 640 samples were from hospitalized patients from different parts of the hospital from which 48.4% of the samples were from the male patients and 51.6% from the female patients and age average of the patients was 60 years and the age range of the patients was from 12 to 99. The highest sensitivity among all samples belonged to vancomycin (more than 90%). and the highest resistance belonged to cephalexin, erythromycin and cefixime (more than 70%). The most common bacterium and the most sensitive antibiotic (with ignoring vancomycin) were as follows, in urine samples: E.Coli 57.9%, nitrofurantoine – blood: negative staph coagulase 33.5%, rifampin – discharge: staph.aureus 38.6%,imipenem– ulcer: staph.aureus 38.6%, nitrofurantoin and co-trimoxazole – sputum : acintobacter 45.5%, rifampin. Conclusion: The results of this research shows extensive increase in the resistance of the bacteria compared to common antibiotics the reason of which may be irregular consumption and prescription of antibiotics, so it is advised that more care shall be used in choosing antibiotics for the treatment and its prescription. Also, precise determination of antibiotic sensitivity pattern needs more extensive investigation with more samples in different treatment centers. SOURCE: URMIA MED J 2013: 24(10): 790 ISSN: 1027-3727