Dr Ali Issazadegan, Dr Seyamak Sheikhy, Dr Sajad Basharpoor,
Volume 22, Issue 6 (Biomonthly Feb-Mar 2012)
Abstract
Background & Aims: Disturbance of the experience, expression of emotions, difficulty in identifying and describing feelings (Alexithymia), negative affectivity, social inhibition (Type-D personality) may influence general health. The aim of the current study was to investigate the relationship and predictability general health through alexithymia and Type-D personality.
Materials & Methods: This descriptive correlation study included 431 samples (193 boys, 238 girls) that were selected through random stratified sampling from Urmia University students and assessed by research instruments: General Health Questionnaire, Toronto Alexithymia Scale, and Type-D Personality Scale. Pearson correlation coefficient and regression analysis were used to analyze the data.
Results: The findings showed that there is a significant relationship between alexithymia and Type-D personality subscales: negative affectivity (r= 0.39, p<0.01), and social inhibition (r=0.44, p< 0.01). There was also significant positive relationship between alexithymia with subscals general health: somatic symptom (r= 0.27, p<0.01), anxiety (r=0.31, p<0.01), social dysfunction (r= 0.34, p<0.01), and depression (r=0.33, p<0.01). Of all research variables, negative affectivity and difficulty identifying feelings were able to predict 36 percent of the variance of general health.
Conclusion: Results of the present study show that individuals with scoring high on alexithymia have poor general health. The relation between alexithymia with negative affectivity can be explained the observed alexithymia-health relationship.
SOURCE: URMIA MED J 2012: 22(6): 587 ISSN: 1027-3727
Dr Sajjad Basharpoor, Dr , Parviz Molavi, Dr Siamak Sheikhi ,
Volume 23, Issue 6 (Biomonthly March-April 2013)
Abstract
Background & Aims : the current study was conducted in the order to compare marital satisfaction and quality of life between patients with obsessive compulsive disorder, patients with other anxiety disorders and normal group.
Materials & Methods : the two 100 member groups comprised of patients with obsessive compulsive disorder and patients with other anxiety disorders, selected of clients that they referred to psychiatry clinic of Fatemi hospital in Ardabil city by accessible sampling method, and one 100 member group of normal people as comparative group, selected randomly, participated in this cross- sectional study. After psychiatric diagnosis, all the groups were tested by questionnaires of obsessive compulsive disorder Enrich marital satisfaction and quality of life. Collected data were analyzed by MANOVA, LSD post hog and independent t tests.
Results : The results showed that there are no significant differences between OCD and normal groups in marital satisfaction but marital satisfaction in people with other neurotic disorders was significantly lower than other two groups. The results also showed that quality of life in both patients with OCD and other neurotic disorders was significantly lower than normal group. Also compared with people with other neurotic disorders, people with OCD had better quality of life.
Conclusion : the result of this research showed that obsessive compulsive patients have high marital satisfaction and quality of life in comparison with patients with other anxiety disorders. These results notifies importance of attention to marital satisfaction and quality of life in diagnose and designing of treatment patterns for mentioned disorders.
Behnaz Mihmanchi, Fateme Sheikhmoonesi, Tarane Enayati, Jamshid Yazdani Charati, Soosan Salari, Samine Fattahi,
Volume 23, Issue 6 (Biomonthly March-April 2013)
Abstract
Background & Aims : Nowadays, in considering the significant role of the Internet in different fields especially in research, Internet anxiety is an important issue. This study determines the relationship between the personality variables with the Internet anxiety of the students of both Mazandaran University of Medical Sciences and Sari Islamic Azad University.
Materials & Methods : This was a descriptive-analytical study. The population included all students studying in Mazandaran University of Medical Sciences and Sari Islamic Azad University in 2011. 342 university students participated in this study selected by stratified randomly method. For gathering data a questionnaire including demographic data and NEO questionnaire was used. For analyzing the data, descriptive and inferential statistics including one sample t-test, Pearson Correlation Coefficient, Multi Variable Regression, and t-test questionnaire were used.
Results : The findings showed that the students had lower level of anxiety than the average (P<0/0. 000). Neurosis also had reversed relation with anxiety and extraversion (r=-0. 26, P<0. 05). Openness, Agreeable, and being conscientious had direct relation with the Internet anxiety. Among these five great personality factors inventory, only neurosis and being conscientious could predict the Internet anxiety.
Conclusion : As neurosis and being conscientious of the five NEO personality characteristics have power to predict Internet anxiety, these two features can be used for preventing the development of Internet anxiety.
Dr Ali Issazadegan, Dr Siamak Sheikhi , Dr Sajad Basharpour, Saeed Saadatmand ,
Volume 24, Issue 1 (Apr-May 2013)
Abstract
Background & Aims: Study and understanding the relationship between effective variables in general health of university students is very important. The aim of the current study was to investigate the relationship and predictability of general health by cognitive emotion regulation strategies and emotional creativity.
Materials & Methods : In this study 323 students (169 females, 154males) were selected by stratified random sampling method from Urmia University. The participants were assessed using the Cognitive Emotion Regulation Strategies Questionnaire (CERS-Q), the Emotional Creativity Inventory (ECI) and the SCL-25 (short-form). The data was analyzed by Pearson correlation coefficient and stepwise regression analysis.
Result: The findings showed that there was a significant relationship between general health with subscales of cognitive emotion regulation strategies including other-blame, catastrophizing ,positive refocusing and acceptance (p<0.01).There was also significant positive relationship between general health with emotional creativity such as effectiveness, novelty, and authenticity (p<0.01). It was found that other-blame, catastrophizing, positive refocusing, acceptance and effectiveness, and authenticity accounted for 37.2% and 17.3% of variance of general health.
Conclusion: The findings emphasized the need to recognize the role of cognitive emotion regulation strategies and emotional creativity in predicting student’s general health.
SOURCE: URMIA MED J 2013: 24(1): 69 ISSN: 1027-3727
Ali Issazadegan, Siamak Sheikhi, Samereh Asadi Majareh ,
Volume 25, Issue 1 (Monthly march 2014)
Abstract
Background & Aims : Individual differences in diurnal preferences and circadian rhythms are viewed as an interesting dimension of human personality. This study aimed to determine the different happiness and satisfaction with life in morning-evening types.
Materials & Methods : The population of the study included 200 students (176 female and 24 male) who were selected by stratified random sampling method from Talesh Payam Nour University. Morning - Evening Questionnaire (MEQ), Short Form of Satisfaction of life (Q-LES-QSF) and Happiness Scale were completed by students. Data were analyzed using multivariable analysis of variance (MANOVA) and LSD post hoc test.
Results : The findings indicated that there were significant differences between diurnal types in satisfaction in life and happiness . Individuals with morning types compared to evening types had a high level of satisfaction in life . The results showed low levels of happiness in the evening type.
Conclusion : The results of this study indicate differences in satisfaction in life and happiness on the basis of circadian rhythms.
SOURCE: URMIA MED J 2014: 25(1): 20 ISSN: 1027-3727
ali Issazadegan, Farazana Mikayili Manee, Seyran Ghaderpur, Siamak Sheikhi , Behrooz Kargar,
Volume 25, Issue 5 (Monthly-July 2014)
Abstract
Background & Aims: In substance use treatment, total intervention is necessary. One of the interventions associated with medical treatment is the training cognitive emotion regulation strategies that have received less attention. The main objective of this study is to check the effectiveness of cognitive emotion regulation strategies on increasing the quality of men’s life treated with methadone in Urmia.
Materials & Methods: In an experimental design with pre-test/post-test with control group paradigm, a sample of 32 patient with hypertension were selected by available sampling method and randomly were assigned to two experimental (n=16) and one control groups (n=16). The measurement tool was World Health Organization-Quality of life (SF-36) Short term Questionnaire. Each group was in drug therapy but the experimental group participated in 12 sessions of training cognitive emotion regulation strategies while the control group did not receive any treatment. The mean scores of the two groups were compared through analysis of covariance (ANCOVA).
Results : Based on the findings of this research, it was clear that in subscales of life’s quality, including interpersonal relationships, physical health and essentials of life, the scores of experimental group were significantly higher than the control groups.
Conclusions The findings of this study suggest that the difficulties in emotional regulations is one of the problems in addict people, and learning how to express emotions regulation correctly and cognitively can be effective in reducing problems and improving the quality of life.
SOURCE: URMIA MED J 2014: 25(5): 434 ISSN: 1027-3727
Robab Sheikhpour, Javad Mohiti Ardekani,
Volume 25, Issue 10 (Monthly_Dec 2014)
Abstract
Background & Aims: Breast cancer is the most common cancer in women. Nearly 50% of breast cancers are dependent to sex hormones, and the effects of these hormones are mediated by their binding to specific receptors. Also p53 protein is mutated in about half of cancers including breast cancer and high level of p53 protein is a common feature of many human malignant cancers. Given that T47D cell line has estrogen and progesterone receptor and p53 protein is product of tumor suppressor gene. This article was devoted to the effect of progesterone on p53 protein in T47D cell line.
Materials & Methods: The breast cancer T47D cell line were grown in 25cm2 flasks in DMEM
with fetal bovine serum (FBS). Then cells were treated with different concentrations (1 nmol, 10 nmol and 20 nmol) of progesterone hormone. The level of proteins was measured by western blot method. Gene tool software was used for data analysis.
Results: There was no differences in p53 protein level in cells that were exposed to 1nmol of progesterone compared to the control group (P>0.05), but cells that were exposed to 10 and 20 nmol of progesterone treatment had lower level of p53 protein concentration than the control (P<0.01).
Conclusion: The result of this study showed that increased progesterone can reduce the level of p53 protein in T47D cell line. It seems progesterone with decreased level of p53 protein reduced accumulation of p53 protein in T47 cell line.
SOURCE: URMIA MED J 2014: 25(10): 960 ISSN: 1027-3727
Samad Beheshtirouy, Davood Aghamohammadi, Farzad Kakaei, Ahmad Sheikhlo , Daniel Fadaei Fouladi , Mahdi Nazari , Mojtaba Ziaee ,
Volume 26, Issue 1 (Monthly_March 2015)
Abstract
Background & Aims: Better clinical outcomes are observed in patients who undergo thoracic procedures under thoracic epidural anesthesia (TEA). This study aimed to compare the outcome of diagnostic thoracoscopy between patients with General anaesthesia (GA) and TEA.
Materials & Methods: In this randomized prospective study 30 candidates of diagnostic thoracoscopy underwent either GA (n=15) or TEA (m=15). Pre-, intra-, and post-operational vital signs and O2 saturation, pre- and post-operational parameters of arterial blood gas (ABG), and post-operational pain, need of analgesics, complications, hospital stay and mortality rate were documented and compared between two groups.
Results: Vital signs and ABG parameters were comparable between the two groups. Although there was better condition in the TEA group, the mean post-operational pain, dose of analgesics and hospital stay were comparable between the two groups statistically. There was no case with intra-operational agitation, change to general anesthesia, complications, need for intensive care unit admission, or mortality.
Conclusion: In candidates of diagnostic thoracoscopy, TEA is at least equal to GA in terms of intra-operational vital signs and parameters of ABG. TEA is superior to GA regarding post-operative pain and hospital stay, but this predominance does not reach a statistically significant level.
SOURCE: URMIA MED J 2015: 26(1): 73 ISSN: 1027-3727
Ali Issazadegan, Siamak Sheikhi, Mohammad Hafeznia, Behrouz Kargari ,
Volume 26, Issue 1 (Monthly_March 2015)
Abstract
Background& Aims: Addictions affect an individual mentally, physically and socially. There are personal, interpersonal and social and environmental causes that interact in its development. The present study aimed to examine the effectiveness of cognitive behavior therapy and pharmacological intervention on increasing efficacy and improving the quality of life in men with substance use.
Materials & Methods: This descriptive-analytical study was conducted on 40 men with substance selected by available sampling method and were divided into an experimental (n=20) and a control group (n=20). Pre-test and post-test was carried out and the data were collected using self-efficacy and World Health Organization Quality of Life Questionnaire. . Pharmacological interventions in both groups were under medical supervision, however, the experimental group received eight sessions of cognitive-behavioral therapy. The mean score of the two groups were compared by covariance analysis (ANCOVA).
Results: The results of study showed significant differences between the mean scores of the pre-test and post-test of the experimental and control groups. Cognitive therapy had enhancing in self-efficacy and quality of life mean score in the experimental group. (p<0/001).
Conclusion: The present findings indicate that pharmacological intervention with cognitive behavioral therapy can be useful in increasing self-efficacy and improving life quality in people with substance use.
SOURCE: URMIA MED J 2015: 26(1): 80 ISSN: 1027-3727
Mehdi Hakimi, Dariush Sheikholeslami-Vatani , Maryam Ali-Mohammadi ,
Volume 26, Issue 3 (Monthly-May 2015)
Abstract
Background & Aims: The purpose of this study was to investigate the effects of resistance and endurance concurrent training combined with ingested of L-Carnitine supplementation on hormonal changes, lipid profile, and body composition in obese men.
Materials & Methods: Twenty four young obese men (age: 23.6±2.4 years and BMI: 32.4±1.6 kg/m2) volunteered to participate in this study and were randomly divided into two groups of 12 people taking the supplement and placebo. Both groups performed the same concurrent resistance and endurance training program (3 times a week for 8 weeks). The supplement group consumed daily 3g of L-carnitine and the placebo group ingested the same amount of maltodextrin. Blood samples were collected before and 36h after completion of the training course in the fasting state. The paired sample t-test was used to determine differences within a group, and differences between groups were analyzed using independent t-test.
Results: In both supplement and placebo groups a significant decrease were seen in body weight, fat mass, body fat percentage, cholesterol, TG and LDL-c after 8 weeks of concurrent training. Moreover, a significant increase was observed in HDL-c (p≤0.05). After more, a significant increase in cortisol (in both groups) and testosterone (only in the supplement group) were observed (p≤0.05). However, in all the variables mentioned, there were significant differences between groups in favor of the group receiving carnitine at the post-test. In other words, the rate of improvement was significantly greater in the supplement group compared to the placebo group (p≤0.05).
Conclusion: Although the implementation of a combination of resistance and endurance training for 8 weeks improves body composition, lipid profile and hormonal changes in obese subjects, but the rate of progress was significantly improved with supplementation of L-carnitine.
SOURCE: URMIA MED J 2015: 26(3): 193 ISSN: 1027-3727
Mahnaz Rasoulzadeh, Gholam Reza Chalabianloo , Reza Abdi , Saeede Sheikh ,
Volume 26, Issue 5 (Monthly-Jul 2015)
Abstract
Background & Aims: The aim of this study was to examine of the role of The Affective and Emotional Composite Temperament (AFECT) model in predicting the symptoms of dysthymic Disorder (DD).
Materials & Methods: In this study, 400 students were evaluated using the Affective and Emotional Composite Temperament Scale (AFECTS) and Cornell dysthymia rating scale. Multivariate regression was used in order to analyze the data.
Results: The results showed that all dimensions of emotional and affective AFECT model, except for fear and euphoria were significantly associated with the symptoms of DD. The results of the regression analysis showed that sensitivity, volition, coping, depression, anxious, hyperthymia, cyclothymic , dysphoric, volatile and apathetic could be predicted significantly symptoms of DD.
Conclusions: The AFECT model could be explaining symptoms ofDD. These findings have theoretical and practical implications for clinical interventions which are remarkable to clinicians .
SOURCE: URMIA MED J 2015: 26(5): 450 ISSN: 1027-3727
Behzad Poopak, Hamideh Rastan, Saghar Rabieipoor, Nazila Safari, Tahereh Madani Esfahani, Mohammad Ali Jahangirpoor, Fatemeh Sheikhsofla, Gelareh Khosravipoor,
Volume 26, Issue 10 (Monthly_Jan 2016)
Abstract
Abstract
Background & Aims:BRAF-V600E mutation has recently been considered as a molecular marker in diagnosis of Hairy Cell Leukemia (HCL). Detection of this mutation has found a diagnostic and therapeutic value. The aim of the present study was comparing the diagnostic value of BRAF V600E mutation detection with other previous methods in diagnosis of HCL patients.
Materials & Methods: Detection of BRAF V600E mutation in 17 patients was performed with allelic discrimination polymerase chain reaction (PCR). The ppatients’ history including results of previous diagnostic tests such as peripheral blood or bone marrow smears as well as flowcytometry immunophenotyping were also collected in order to compare the diagnostic value of BRAF V600E mutation testing with other routine methods in diagnosis of HCL.
Results: Lymphoid cells with hairy-like projectionswere observed in smears of 14 patients. Immunophenotyping by flow cytometry for HCL in these patients were reported as “Definitely Diagnosed” in 9 cases, “Highly Suspicious” in 4 cases and “Suspicious” in 1 case, while BRAF V600E mutation were detected in all of them. Microscopic and flow cytometric analysis for three remaining patients ruled out the presence of HCL, which were related with absence of BRAF V600E mutation in these patients.
Conclusion:Since the results of mutation detection confirmed the final report of two other tests, it can be concluded that BRAF V600E mutation detection has a high diagnostic value and is an appropriate confirmation test in this regard.
SOURCE: URMIA MED J 2016: 26(10): 889 ISSN: 1027-3727
Dariush Sheikholeslami-Vatani, Mohammad Reza Bolurian, Rahman Rahimi,
Volume 26, Issue 11 (Monthly_feb 2016)
Abstract
Background & aims: Some studies have shown that beta-alanine supplementation may delay fatigue during strenuous exercises. The aim of this study was the effect of 10 days β-alanine supplementation with different doses on neuromuscular fatigue and blood lactate levels. Material & methods: 40 active men with a mean age of 21.9±2.6 years and body mass index 24.54±1.8 kg/m2 were randomly divided into four groups of 10 people including: 2, 4 and 6 g doses of beta-alanine supplement (Experimental groups) and placebo (control) group. Competitors completed four 30-second Wingate tests with maximum power, before and after 10 days beta-alanine supplementation period. 4 minute rest interval was set between each exercise. The first blood sampling administrated before first exercise and second one after 6 minutes of fourth exercise. The EMG amplitude as neuromuscular fatigue index was measured before the first wingate and during the fourth wingate test. Results: the result showed that supplementation with different doses of β-alanine has no effect on M wave amplitude in vastus lateralis muscle. In other words, neither within-group (P=0.078) and between-group changes (P=0.66) was significant. Moreover, after repeated wingate exercises, amount of lactate in all groups (received β-alanine supplement and placebo group) increased significantly (p=0.000), while, no difference showed between groups (p=0.1). Conclusion: The present findings suggest that doing repetitive maximal exercises results in significant increase of lactate, but short-term β-alanine supplementation with different doses has no effect on neuromuscular fatigue and blood lactate accumulation.
Marjan Sheikholeslami, Hassan Javadzadegan, Mehrzad Hajialilo, Seyyed Sadredin Rasi Hashemi , Leila Gadakchi, Alireza Khabbazi,
Volume 27, Issue 2 (Monthly_May 2016)
Abstract
Background & Aims: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by various autoantibodies formation and immune complex deposition in various organs. Lupus nephritis is a common and severe manifestation of SLE that can lead to end stage renal disease and death. The aim of this study was to evaluate the long-term efficacy of cyclosporine A in the treatment of resistant proliferative lupus nephritis.
Materials & Methods: In a retrospective study, patients with proliferative lupus nephritis that were resistant to treatment with mycophenolate mofetil and/or cyclophosphamide and was treated with cyclosporine A were entered to the study. They were evaluated according to the remission of the renal disease, SLE disease activity index, occurrence of end stage renal disease, mortality and side effects of treatment.
Results: Twenty-five patients with biopsy proven proliferative lupus nephritis with mean age of 30±6.9 years including 5 men (20%) and 20 women (80%) were studied. The follow up duration was 27.1±17.6 months. Proteinuria was decreased significantly during the treatment with CSA (p<0.001). Serum creatinine was stable and changes was not significant. Complete renal remission and partial renal remission was occurred in 60% and 32% of patients, respectively. Prednisolone dose was reduced from 26.3 mg/d before treatment to 6.8 mg/d after treatment with CSA (P=0.001). The most common adverse event was dyspepsia.
Conclusion: According to results of our study, CSA is effective in the treatment of proliferative lupus nephritis.
SOURCE: URMIA MED J 2016: 27(2): 129 ISSN: 1027-3727
Ehsan Saboory, Siamak Sheikhi , Salman Ghaderi, Bita Rezazadeh, Hasan Azizi ,
Volume 27, Issue 4 (Monthly_jul 2016)
Abstract
Background &Aims: Child Abuse (CA) is a multi-dimensional damage which is emerged and intensified by several elements. CA brings about physical, mental, and social aftermaths for the children and exposes them to several dangers. This study aimed to investigate the correlation between Substance Abuse and CA in Tehran.
Materials & Methods: This study was conducted through a survey, and systematic random sampling method was used. The statistical population of this study was Child Abuse in Tehran in 2014-15. The sample population of this study was 273 individuals which were selected using Cochran Sampling Formula among the Child Abuse. The questionnaires were also analyzed after investigating validity and reliability of the questions.
Results: The findings of this research showed that girls and boys are abused equally. Moreover, as the age of the children increases, the possibility of being abused increases too. The most common insult was physical and physical-mental abuse. Most of the children have experienced a combination of physical, mental, and sexual abuse and neglect. Also, findings of this study showed that addiction of the parents was the main element of CA (43% of cases); and there was a significant relationship between parental Substance Abuse and CA. Dependency to methamphetamine was the most common addiction compared to other drugs (83%).
Conclusion: Considering these results, the necessity of multi-dimensional planning in individual, family, and social levels and in three preventive phases of first, second and third is needed for effective prevention and appropriate intervening on CA.
SOURCE: URMIA MED J 2016: 27(4): 309 ISSN: 1027-3727
Ali Isazadegan, Esmail Soleymani, Behrooz Khosravian, Siyamak Sheikhi,
Volume 27, Issue 9 (Monthly-Oct 2016)
Abstract
Background & Aims: Motivation for the cosmetic surgery has its roots in a combination of psychology, emotional, and personal factors. The aim of the present study was to compare the social competence and cognitive emotion regulation in rhinoplasty cosmetic surgery applicants and normal individuals.
Materials & Methods: The study was a causal comparative research. Statistical population of the study involved 116 rhinoplasty cosmetic surgery applicants that referred to two cosmetic surgery clinics in 2015 in Urmia city during a two-month period. About 20 people were selected through random sampling as major group and 20 normal individuals were matched with them as comparison group. The data were collected with the short version of Cognitive Emotion Regulation Questionnaire and Social Competence Questionnaire and the data were analyzed through multivariate analysis of covariance.
Results: The results of multivariate analysis of covariance showed that there was a significant difference between applicants for rhinoplasty cosmetic surgery and normal individuals in regard to social competence and cognitive emotion regulation. In other words, the mean of components of social competence and cognitive emotion regulation was different in both groups.
Conclusion: The results indicated that some personality traits such as social competence and cognitive emotion regulation may have an important role in the tendency to cosmetic surgery and paying attention to them can have an important role in reducing the demands of clients.
SOURCE: URMIA MED J 2016: 27(9): 743 ISSN: 1027-3727
Elaheh Piralaiy, Marefat Siahkuhian, Saeed Dabbagh Nikokheslat, Lotfali Bolboli, Naser Aslan Abadi, Mahboub Sheikhalizadeh, Saeid Fathollahi,
Volume 28, Issue 6 (Monthly_Sep 2017)
Abstract
Background & Aims: Type 2 diabetes is commonly associated with autonomic neuropathy. The aim of the present study was investigated the impact of glycemic control and disease duration (DD) on autonomic nervous function in Type-2 Diabetic Neuropathy Men by analysis of their heart rate variability (HRV).
Materials & Methods: fifty-three Man with diabetes and peripheral neuropathy were recruited and categorized into four groups by HbA1c of 7% and DD of 10 years: group I (n = 16, HbA1c < 7%, DD < 10 years), group II (n = 13, HbA1c < 7%, DD ≥ 10 years), group III (n = 10, HbA1c ≥ 7 %, DD < 10 years), and group IV (n = 14, HbA1c ≥ 7 %, DD ≥ 10 years). HRV parameters as determined by separate frequency domain components (low frequency: LF, 0.04–0.15 Hz; high frequency: HF, 0.15–0.5 Hz; very low frequency: VLF, 0.0033–0.04 Hz; total power: TP, 0.04–0.5 Hz) were measured at rest. Two-way analysis of variance were used for statistical analysis and Hochbergs Post hoc test were used for determination place differences couple.
Results: The main effect of HbA1c, DD and their interactions effect were significant with TP and VLF. While only the main effect of DD were significant with LF and HF. Hochbergs Post hoc test results for determination place differences couple showed that between TP and VLF were different according to HbA1c and DD. So that mean of TP and VLF significantly was higher in group I (HbA1c < 7%, DD < 10 years) than II, III and IV groups.
Conclusion: These findings suggest that disease duration (DD) and early and intensive care in glycemic control is a key factor for preventing the occurrence of CAN in Type-2 Diabetic Neuropathy Men.
Mehdi Hakimi, Marefat Siahkouhian, Lotfali Bolboli, Dariush Sheikholeslami Vatani,
Volume 28, Issue 10 (Monthly_Jan 2018)
Abstract
Background & Aim: The purpose of this study was to investigate and compare the effects of eight weeks resistance and endurance training with vitamin D3 supplementation on inflammatory cytokines in obese hypertensive middle-aged men.
Materials & Methods: Sixty three obese hypertensive middle-aged men (age= 39.85±2.8 years and BMI= 31.6±1.4 kg/m2) volunteered to participate in this study and were randomly divided into six groups of resistance training with vitamin D (R+D, N=11), resistance training with placebo (R+P, N=12), endurance training with vitamin D (E+D, N=9), endurance training with placebo (E+P, N=11), vitamin D (D, N=10) and control (C, N=10, no intervention). The training protocol consisted of endurance training with gradually increasing of duration and intensity and resistance training with 80% of the 1RM, 3 times a week for 8 weeks. The supplement groups consumed daily 3000 IU of vitamin D and the placebo groups ingested the same amount of maltodextrin. Blood pressure and blood samples were measured before starting training protocol and 36 hours after last training sessions.
Results: In intervention groups, serum levels of interleukin-8 and interleukin-4 were significantly decreased and increased, respectively. Also, in training groups, systolic and diastolic blood pressure were significantly decreased. Moreover, only in the systolic blood pressure there were significant differences between groups in favor of the E+D group at the post-test.
Conclusion: Implementation of endurance and resistance training with vitamin D3 for 8 weeks caused to decreases of blood pressure and inflammation in obese hypertensive men, but the effect of endurance training with vitamin D3 on systolic blood pressure was significantly better.
Sanaz Sheikhzadeh, Nowruz Delirezh, Rahim Hobbenaghi,
Volume 29, Issue 8 (Monthly_Nov 2018)
Abstract
Background & Aims: Cancer immunotherapy, despite its many benefits, faces major challenges. Nanoparticles are drug delivery systems that may address these challenges. The goal of this study was to produce the tumor cell lysate and Poly-IC loaded nanoparticles with desirable properties and evaluation of their therapeutic effects in mouse model of breast cancer.
Materials & Methods: Nanoparticles were prepared by the double emulsion solvent-evaporation method, using poly (vinyl alcohol) (PVA) as a surfactant. Effects of molecular weight variation and the degree of hydrolyzation of PVA were investigated for the particle size, polydispersity index, encapsulation efficiency and the residual surfactant percentage of nanoparticles. 4T1 Cell line was used to induce the breast tumor in mice. To evaluate the effectiveness of the vaccine, tumor growth rate, proliferation of splenic cells by MTT assay and Delayed Type Hypersensitivity (DTH) reaction were evaluated.
Results: These results showed that the use of polyvinyl alcohol with a molecular weight of 13-23 kDa and 87-89% hydrolysis, produced nanoparticles with desirable properties. Although injection of nanoparticles containing tumor cell lysate with or without poly-IC to mice, caused a significant decrease in tumor growth, increased splenic lymphocyte proliferation, and delayed type hypersensitivity response in these two groups. But these changes, in the group that received nanoparticles containing the tumor cell lysate with Poly-IC were more significant than other groups.
Conclusion: The results showed that the co-encapsulation of tumor cell lysate and poly-IC in one nanoparticle, due to the effects of Poly-IC on the maturation and activation of dendritic cells, enhance anti-tumor immune responses and can be considered as an effective therapeutic strategy for the treatment of breast cancer.
Dr Mahmoud Sheikh, Shahin Ramezani, Khaled Ahmadi,
Volume 30, Issue 4 (July 2019)
Abstract
Background & Aims: Birth weight is an important indicator of child health that affects various aspects of physical and cognitive development. This study aimed to compare the anthropometric indicators, IQ, and motor development in preschool children with and without low birth weight.
Materials & Methods: The type of this research is comparative.The population consisted of preschool children in Marivan city. Among kindergartens in Marivan city, 37 children with natural birth weight (above 2500 g) and 37 children with low birth weight (below 2500 g) were selected purposefully. In two groups, children with low birth weight and children with normal birth weight were included. To evaluate the development of gross and fine motor skills, the short version of the Bruininks-Oseretsky test of motor proficiency was used and also the Wechsler-4 Intelligence Scale was used to measure the IQ of participants. Meter and balance tools were utilized to measure anthropometric indices.
Results: The data were analyzed using independent t-test, multivariate analysis of variance, and one way ANOVA in MANOVA text (significance level of 0/0001). The results showed significant differences in anthropometric, IQ, coarse and delicate skills between two groups. Children with normal birth weight showed higher performance in these indices.
Conclusion: The results showed significant differences in anthropometric indicators, IQ, and motor development among preschool children with and without low birth weight there.
