Dr Afsane Amirabi, Dr Sarie Golmohammadlu, Dr Zahra Yekta, Dr Siamak Naji, Dr Shahla Danaii,
Volume 21, Issue 1 (spring 2010)
Abstract
Received: 21 April, 2009 Accepted: 21 Oct, 2009
Abstract
Background & Aims: Proteinuria is one of the fundamental criteria for diagnosis of pre-eclampsia with quantative assessment based on twenty-four-hour urine protein estimation as the gold standard. The purpose of this study is to determine the correlation between four and twenty-four-hour urine total protein values to confirm the diagnosis of proteinuria in hypertensive disorders of pregnancy.
Materials & Methods: The study population included 100 patients with hypertensive disorders of pregnancy. The patient's urine was collected over twenty four hours with the first four hours, next twenty hours in separate containers. The urine volume, total protein and creatinine levels were measured in the 4 and 24 hour samples. The 4-hour results were compared to the 24-hour results using simple regression analysis.
Results: From 100 patients, 42 had no proteinuria, 44 had mild proteinuria, and 14 with sever proteinuria. The protein value of four-hour sample correlated with those of the twenty four-hour sample for patients with mild and sever disease (P<0.001, r=0.86).
Conclusion: This study showed there is a correlation between four-hour urine protein and twenty four-hour urine protein and we can substitute the results of the first test for the latter one.
Keywords: Four-hour urine collection, Proteinuria, Preeclampsia, Hypertension in pregnancy, Twenty four-hour urine collection
Address: Department of Gynecology, Motahary Hospital, Urmia, Iran Tel: (+98441) 2220952
E-mail:afsaneh_amir@yahoo.com
Source: UMJ 2010: 21(1): 097 ISSN: 1027-3727
Marzieh Akbarzadeh, Raheleh Mirmojarabian, Dr Mohamadebrahim Parsanezhad, Tahereh Keshavarz, Dr Najaf Zara,
Volume 22, Issue 1 (mar-apr biomonthly 2011)
Abstract
Background & Aims: Polycystic ovarian syndrome is one of the most common hyper androgenic disorders in reproductive age. Women with lack of ovulation and hyper androgenic are exposed to non-insulin dependent diabetes. Our goal was the survey of abnormal glucose tolerance, insulin resistance and risk factors that affect the incidence of diabetes type2 in patients with polycystic ovary syndrome (PCOs).
Materials & Methods: In this descriptive – analytic study 150 patients with simple purposive sampling method were selected. Among the subjects, laboratory tests were performed on 125 patients. Data collection tools were included Questionnaire, weight scale, measuring tape, fasting blood sugar test, fasting insulin and glucose tolerance test by75 gr glucose. Prevalence of diabetes type 2 and age relation, BMI, central obesity, glucose tolerance and insulin resistance measured and then data were analyzed using SPSS software and Chi square statistical tests.
Results: Abnormal glucose tolerance rate was 8 percent. Also 14.4 percent of the patients had impaired fasting glucose and 4 percent of the patients had diabetes type 2 according to the results of the fasting blood sugar test.In8.9 percent of the subjects insulin resistance was observed. In 66 percent of the patients BMI was equal or more than 25 kg/m2. 76 percent of the patients had android obesity. Also a positive correlation between waist to hip ratio and glucose tolerance (r=0.25) and significant statistical difference was seen in these two parameters.
Conclusion: Due to the emergence of insulin resistance and diabetes in patients with polycystic ovary syndrome, screening for IGT and diabetes type 2 in these patients is recommended.
Source: Urmia Med J 2011: 22(1): 83 ISSN: 1027-3727
Dr Mehrdad Mirzarahimi, Dr Mohamad Mazani , Hakimeh Saadati, Dr Abdin Binazadeh, Dr Afsaneh Enteshari,
Volume 22, Issue 4 (biomonthly septamber-octobr 2011)
Abstract
Background & Aims: Febrile convulsion is one of the most common causes of hospitalization of children in pediatric wards. The exact pathogenesis of seizure is not fully understood but involves several factors like genetic predisposition, changes in the levels of neurotransmitters, and some trace elements. The present study was conducted to evaluate the cerebrospinal fluid (CSF) zinc (Zn) level in children with types of febrile convulsion.
Materials & Methods: This descriptive-analytical study was carried out from August 2008 to October 2009 to see the status of zinc in CSF of 26 children (6 months to 6 years) with febrile convulsion. All the patients who entered the study had an indication for lumbar puncture. We collected CSF samples from all children and assessed the concentration of zinc using flame atomic absorption spectrophotometry (AAS). We compared CSF zinc levels regarding seizure type and sex of children using statistical analysis.
Results: Mean CSF zinc level in simple and complex febrile seizures were 2.1081 ± 0.5655 and 1.575 0.2339 [ m g/dl), respectively. This difference was statistically significant (P= 0.01). However, there was no relationship between CSF zinc status with sex (P=0.19).
Conclusion: These finding revealed that CSF zinc level is higher in simple febrile convulsions than the complex febrile convulsions. CSF zinc concentration (μg/dl) did not differ between boys and girls significantly.
S0urce: Urmia Med J 2011: 22(4): 381 ISSN: 1027-3727
Masoumeh Akbari, Dr Rahim Nejad Rahim, Afsaneh Azimpour, Dr Iraj Bernousi, Dr Hoshyar Ghahremanlu,
Volume 23, Issue 6 (Biomonthly March-April 2013)
Abstract
Background & Aims : As more than 20% of nosocomial infections occur in intensive care units and the crude mortality rate is between 10 and 80%, the objective of the present study was to survey the prevalence of nosocomial infections to provide appropriate preventive guides based on international standards.
Material & Methods : The present Descriptive and analytical, cross-sectional study was carried out on 101 patients with hospital-acquired infections in one year. Data were analyzed using SPSS to compute descriptive and analytical statistics.
Results : The total cross infections rate was 0.4% of which 54.45% was for the intensive care units. The highest infections occurred in the respiratory system (47.27%). Significant differences was observed between the numbers of patients with cross infections in various wards (P<.001). The average hospital stay was 21. 19 days for the intensive care unit and significant differences was also observed between patients with cross infections with various length of hospital stay (P<.05), and was between male and female patients with cross infections number in various hospital wards (P<.001).
Conclusion : The prevalence of patients with cross infections was below the standards . The results of current study is made us aware of the significance of a more exact investigation of declared cross infection reports of the hospitals, the standardization of those reports, and solving the existing problems.
SOURCE: URMIA MED J 2013: 23(6): 704 ISSN: 1027-3727
Maryam Kashanian, Hamid Reza Baradaran , Hourieh Hatami , Afsane Ghasemi ,
Volume 23, Issue 7 (3-2013)
Abstract
Received: 23 Sep, 2012 Accepted: 22 Nov, 2012
Background & Aims : Substance abuse during pregnancy is one of the most important problems in maternal and neonatal health.
Being familiar with the risk of poor pregnancy outcome in these individuals may help them to reduce that risk. The purpose of the present study is to evaluate the effects on Pregnancy outcome of substance abuse during pregnancy.
Materials & Methods : The study was conducted as a historical cohort study between two groups of pregnant women with or without substance abuse. Both groups were Iranian housewives, with the same socio economical status, singleton and without any known medical systemic disorder.
Results : 1268 women were evaluated in total. 317 women were drug abusers and 951 women were not. The woman in both groups had no significant differences according to neonates’ gender, gestational age, pregnancy-induced hypertension, intra uterine fetal death (IUFD), and ruptured membranes. Maternal age (P=0.000), maternal weight (P=0.000), neonatal weight (P=0.000) were found to be lower in drug abusers. History of previous abortion (p=0.000) and gravidity (P=0.000) were higher in drug abusers. Also cesarean delivery [(P=0.049, RR=1.1 (1.02-1.12)], placental abruption [(P=0.000, RR=2.7 (1.8-4.1)], meconium passage [P=0.000, RR=2.6 (2.3-2.8)], neonatal weight of less than 2500 gram [P=0.000, RR=1.9 (1.8-2)], Apgar score of less than 7 in minute 5 [P=0. 001, RR= 1.7 (1.5-1.7)], NICU admission [P=0.000, RR= 3.7 (3.5-3.8)] and neonatal death [P=0.009, RR= 2.1 (1.8-2.5)] were all higher in drug abusers.
Conclusion : Substance abuse causes poor outcomes in pregnancy, and with control, patients may improve these poor conditions.
Keywords : Substance abuse, drug abuse, pregnancy, pregnancy outcomes, low birth weight, Apgar Score, NICU, pregnancy induced hypertension (PIH), placental abruption.
SOURCE: URMIA MED J 2012: 23(7): 824 ISSN: 1027-3727
Ahmad Alipour, Afsaneh Rahimi, Hossein Zare ,
Volume 24, Issue 7 (Monthly-Oct 2013)
Abstract
Background & Aims : The connection between mental health and marital satisfaction has been significant for researchers. The mental health plays an important role in family function and also in quality of life. The purpose of the present study was to examine the connection between the health of psyche and marital satisfaction in married students.
Materials & Methods : This descriptive-correlative study was conducted on 320 samples that were selected from the married students of Payame-Noor University of Tehran (160 man and 160 women) by available sampling method. Examinees answered to the General Health Questionnaire of Goldberg (GHQ) and the Marital Adjustment Test of Lucke (LMAT). In order to analyze the data, we used Pearson Correlation Coefficient and Simple Linear Regression.
Results: Correlation between mental health and marital satisfaction (r =0.42) was achieved. The results of Linear Regression also showed that the mental health with declaration power r2 = 0.18 can declare marital satisfaction variance.
Conclusion: The achieved results from this study show that the health of psyche variable plays an essential role in marital satisfaction of couples.
SOURCE: URMIA MED J 2013: 24(7): 565 ISSN: 1027-3727
Shahryar Sane, Alireza Mahoori, Mohammad Amin Valizad Hasanloei, Nazli Karami, Roya Poormohammad,
Volume 27, Issue 2 (Monthly_May 2016)
Abstract
Background & Aims: Although intraspinal opioid has been presented to be effective in providing analgesia after cesarean delivery, pruritus as a side-effect remains a common cause of dissatisfaction. We undertook a study to assess the efficacy of ondansetron for treatment or prophylaxis of intrathecal fentanyl-induced pruritus. The role of ondansetron has been studied in preventing pruritus but the results have been contradictory.
Materials & Methods: We randomized 110 patients undergoing elective cesarean section using spinal anesthesia with Marcaine 10 mg plus fentanyl 25 µg and into a double-blinded trial to receive ondansetron 4 mg (study group) or placebo (control or placebo group) after clamping of umbilical cord. Intra and post-operative itching, nausea and vomiting, and shivering in the recovery room were registered.
Results: Forty percent of the patients in the placebo group and 23.6% in the ondansetron group had itching intraoperative (P=0.04). The incidence of post-operative itching was 38.2%, 21.8% in placebo and ondansetron groups, respectively (P=0.04). The patients reported less intra and post-operative nausea and vomiting in the ondansetron group than in the placebo group (P=0.01). There was no difference in the incidence of shivering between two groups.
Conclusion: This study showed that the prophylactic ondansetron reduced itching, nausea and vomiting intra and postoperative caused by intrathecal fentanyl with marcaine
SOURCE: URMIA MED J 2016: 27(2): 154 ISSN: 1027-3727
Alireza Mahoori, Shahryar Sane, Mitra Golmohammadi, Hedyeh Rezaei, Zahra Mali,
Volume 27, Issue 11 (Monthly-Feb 2017)
Abstract
Background & Aims: In general anesthesia, patients’ coughing during and after recovery is an important clinical problem with a prevalence of 15% to 45%. This study aimed to evaluate the effects of alkalinized lidocaine or lidocaine alone into the tracheal tube cuff on post-extubation cough in lumbar laminectomy surgery with general anesthesia.
Materials & Methods: Ninety patients scheduled for lumbar laminectomy in prone position were enrolled in this randomized double-blind prospective study. After tracheal intubation, the tracheal tube cuff was filled with either an alkalinized 2% lidocaine solution or lidocaine alone or 0.9% saline. A logistic regression comprising the two factors was used for analysis. The incidence of sore throat reported by patients and cough 0, 10 and 30 minutes at recovery after extubation.
Results: Intracuff alkalinized 2% lidocaine was superior to lidocaine alone and saline in blunting emergence coughing 10 and 30 minutes at recovery after extubation (P = 0.035- P= 0.005). The incidence of sore throat was significantly lower in the alkalinized 2% lidocaine group at the recovery at 10 and 30 min after extubation(p = 0.001).
Conclusion: The present study showed that the intracuff alkalinized 2% lidocaine was superior to lidocaine alone or saline in decreasing the incidence of emergence coughing and sore throat during the recovery room after extubation.
SOURCE: URMIA MED J 2017: 27(11): 941 ISSN: 1027-3727
Kazhal Mobaraki , Shaker Salari Lak , Hamid Reza Khalkhali , Afsane Farkhondi Sorkhabi,
Volume 28, Issue 1 (Monthly_Apr 2017)
Abstract
Background & Aims: Congenital hypothyroidism is one of the most prevalent hormone disorders and the most important preventable cause of mental retardation. The aim of this study was to assess the effectiveness of congenital hypothyroidism screening program in Sardasht from 2008 to 2014.
Materials & Methods: In this sequential cross sectional study, after making the necessary arrangements and obtaining permission from the Department of Health, the data related to 10950 infants with congenital hypothyroidism during 2008 to 2014 were gathered and assessed by census method using specific forms related to the disease. All statistical analyses were performed using SPSS program version 21. The P-value< 0.05 was considered to be statistically significant.
Results: Of 17245 newborns, 17074 were screened and 171 ones were not. On the whole, the data for 10950 newborns were accessible (5582 boy, 5363 girls).The results showed that the coverage rate of screening program was %99, recall rate %4.5 and prevalence rate 6.6 per 1000. And 2% of blood samples sent to laboratory did not satisfy the criteria. The average time of treatment for confirmed cases was 26.74 days after birth.
Conclusion: Screening program identified 114 patients during the seven years of the study period and also with 100% coverage rate and treatment of confirmed cases; it has been effective and operated successfully in order to reduce physical disabilities and mental disorders. Some indicators still need to be considered such as the time of first sampling and average time to onset the treatment. In this regard, more effort is needed to achieve the ultimate goal of the screening program.
Shahryar Sane, Alireza Mahoori, Nazli Karami, Hedyeh Rezaei, Mahsa Rezapoure,
Volume 28, Issue 3 (Monthly_Jun 2017)
Abstract
Background & Aims: Nausea and vomiting during spinal anesthesia for elective cesarean delivery is a common finding and may occur in up to 80% of patients. The aim of the present study was to compare efficacy of using intravenous midazolam alone, ondansetron, and midazolam in combination with ondansetron for prevention of nausea and vomiting during and after cesarean delivery in parturient that underwent spinal anesthesia.
Materials & Methods: In a double-blind study, 126 women undergoing elective caesarean section under spinal anesthesia (using 0.5% bupivacaine 12.5 mg) were allocated randomly to receive midazolam 2 mg (n=42), ondansetron 4 mg (n=42) or midazolam and ondansetron (n=42) after the clamping umbilical cord. The frequency of nausea and vomiting during and after surgery in recovery room were recorded.
Results: The frequency of intraoperative nausea and vomiting was lower in the O (28.6, 7.1%) and MO (26.2, 16.7%) groups compared with M (50, 31%) group (P=0.04, P=0.006). The frequency of nausea and vomiting after surgery in recovery room was lower in the O (4.8, 19 %) and MO (11.9, 7.1%) groups compared with M(38.1, 23,8 %) group (P=0.01, P=0.03). Metoclopramide consumption was lower in O and MO groups compared with M group (P=0.02). There was no difference in mean arterial pressure and pulse rate between three groups during the surgery at times measured.
Conclusion: A bolus dose of midazolam (2 mg) was not effective than ondansetron (4mg) and ondansetron plus midazolam (O 4 and M 2 mg) for the prevention of nausea and vomiting in parturient patients undergoing cesarean section with spinal anesthesia during and after surgery in recovery room; however, further studies are needed.
Mohammad Hossein Rahimi Rad, Mohammad Amin Valizade Hasanloei, Shahryar Sane, Nasim Alidaei, Shaghaiegh Rahimi_rad,
Volume 28, Issue 8 (Monthly_Nov 2017)
Abstract
Background & Aims: Recent studies have shown that thrombocytopenia (TP) is associated with poor outcomes in patients with pneumonia, burns, and H1N1 influenza. The aim of this study is to determine the impact of platelet count trends and TP on mortality in intensive care unit (ICU) patients.
Materials & Methods: TP was defined as <150,000 platelets/ml. In this study, 300 patients who had been admitted to the ICU for internal diseases were evaluated for platelet counts on the day of admission and following days to assess the presence of TP. Comparisons were made between patients who died in the ICU and those who were discharged for presence of TP, mean platelet counts, and changes in platelet counts. Platelet count trends were evaluated with repeated measurement tests. P < 0.05 was significant.
Results: Of 300 patients, 131 (43.7%) had TP upon admission to the ICU. The rates of TP were 60% among patients who died as compared to 34% among surviving patients (p < 0.001, risk ratio = 3.07, 95% CI 1.88–5.01). Mean platelet counts on admission day and all four of the following days were significantly lower in patients who died than patients who survived (p < 0.001). On the days after admission, platelet counts tended to increase in surviving patients and decreased among non-surviving patients.
Conclusion: TP is commonly observed in ICU patients. TP diagnosis and trends of decreasing platelet counts over time are each predictors of mortality among ICU patients. Because platelet counts are inexpensive and readily available, our findings suggest that their use helps inform clinical decision-making in patients with critical illness.
Massumeh Payandeh, Fatemeh Nahidi, Maliheh Nassiri, Afsaneh Fouladi ,
Volume 28, Issue 9 (Monthly_Dec 2017)
Abstract
Background & Aims: Several physical and psychological factors affect the severity and duration of labor pain
. Factors such as maternal age, parity, cervical position at the onset of labor, and the relationship between the size and position of the embryo with the size of the canal of delivery are important factors in the severity of labor pain. Effective psychosocial factors that may affect physical factors include fear, anxiety, cultural beliefs and companionship in the delivery room. The severity of pain varies from one person to another, and according to published reports, 15% have mild pain, 35% have moderate pain, 30% have severe pain, and 20% have reported uncommitted pain. Considering the painful nature of labor, the present study was conducted to compare the effect of TENS with hyoscine-promethazine on reducing the frequency of labor pain in the active phase of labor.
Materials & Methods: By a clinical ergometric method, this research was done on 84 eligible pregnant women (42 in TENS group; 42 in hyoscine- promethazine group) referring to Shahid Chamran Hospital of Kangavar city. When active phase of labor began, 20 mg of hyoscine and 25 mg of promethazine were simultaneously administered to the medication group intramuscularly. For TENS group, TENS device was used, with a pair of upper electrodes being between L1-T10 and a pair of lower ones between S2-S4 on both sides of spinal column. Pain scores were studied under per- and post- intervention conditions for 2 groups. Collected data was analyzed by using SPSS software, chi- square test and independent t-test at p<0.05.
Results: Two groups were tested for variables of age, body mass index (BMI), pregnancy age, dilatation at the time of admission, exhibiting no significant differences (p>0.05). The means of contraction duration (p>0.05) and of contraction number (p>0.05) did not differ significantly for 2 groups. But results from comparison of the mean pain scares of 2 groups of studied pregnant women showed that it was significantly lower for TENS group throughout active labor phase at different dilatations than for the other group (hyoscine- promethazine) (p<0.05).
Conclusion: TENS relieves labor pain; therefore, it is recommended to use it for this purpose.
Nazli Karami, Ebrahim Hassani, Shahryar Sane, Amir Shabani,
Volume 30, Issue 11 (February 2020)
Abstract
Background & Aims: Postpartum hemorrhage is one of the life-threatening complications after labor and cesarean section. Its prevalence is 6 percent. Metratonia is the most common cause of this complication. Some medications can prevent it. Oxytocin is the most common uterine vasoconstrictor and is used routinely after delivery for decreasing hemorrhage. The aim of this study is to compare hemodynamic changes of oxytocin infusion under general anesthesia with spinal anesthesia in elective cesarean section.
Materials & Methods: In this observational study, 120 pregnant patients with ASA I and II candidate for elective cesarean section were enrolled in two groups randomly. In one group, general anesthesia and in the other group spinal anesthesia was performed. The heart rate, systolic, diastolic, and mean arterial pressure of patients were recorded every minute until delivery. After umbilical cord clamping and infusion of 30 units dose of oxytocin, the hemodynamic parameters were evaluated every 3 minutes for 30 minutes.
Results: Until the delivery, the heart rate, systolic, diastolic, and mean arterial pressure of patients were higher in the general anesthesia group (p=0.002). After beginning oxytocin infusion, these parameters were different in two groups and were higher in the group under general anesthesia. But only the difference of systolic blood pressures was significant (p=0.01)
Conclusion: We can conclude that in the cesarean section, the type of anesthesia impression on hemodynamic changes due to oxytocin infusion is only observed on systolic blood pressure and there is no significant difference in other hemodynamic parameters.
Afsaneh Amirabi, Sedigheh Ghasemian Dizajmehr, Sima Molla,
Volume 33, Issue 3 (June 2022)
Abstract
Background & Aims: Urinary incontinence is one of the prevalent hygienic problems of women that is negatively affecting physically, psycho- socially on quality of women’s life. The aim of this study was to evaluate the effectiveness and safety of stress urinary incontinence surgery by the trans-obturator tape method (minimally invasive).
Materials & Methods: In this cross-sectional study, 30 women with stress urinary incontinence who underwent the TOT procedure in the in the Gynecology Department of Motaharri hospital, Urmia, Iran between August 2016- December 2017 were included. All patients underwent pre-operative clinical examination, cough-stress test in lithotomy position with full bladder, bladder sonography and post-voiding residual volume assessment.
Results: The Mean ± SD age of patients was 43.7±7.62 years, ranging from 30 to 58 years. Patient were followed at the months of 1and 6 after surgery. The average duration of the surgery was about 20 minutes. 100% of patients were completely cured and none of patients have failure of treatment or surgery complications.
Conclusion: In this study, trans-obturator tape placement was found to be a safe, effective and low-complication method. All patients were satisfied with the surgical results. Considering the relatively small number of people studied, it is recommended to conduct more studies, especially focusing on evaluating the quality of life with standard questionnaires in the field of women's urinary problems. Also, clinical trial studies should be designed and implemented in the field of comparison of TOT with existing standard surgical methods in the treatment of female incontinence.
Ali Ashrafi, Shahryar Sane, Simin Atash Khoii,
Volume 33, Issue 6 (September 2022)
Abstract
Background & Aim: Nephrolithiasis is one of the common diseases that is seen in one case out of thirteen women and one case out of seven men. The aim of this study was to compare the effect of prophylactic Phenylephrine in the prevention of hypotension during spinal anesthesia percutaneous nephrolithotomy surgery.
Materials & Methods: In this experimental study, 60 patients undergoing percutaneous nephrolithotomy surgery with ASA I and II, were randomized to receive prophylaxis with ephedrine or placebo immediately before the spinal anesthesia. Patients in the ephedrine group received an intravenous bolus of 10 mg ephedrine. Mean arterial, systolic and diastolic blood pressure, heart rate, nausea, and vomiting during surgery and recovery were recorded.
Results: The incidence of blood pressure drop in the ephedrine group was lower than spinal anesthesia in 3, 6, 9 and 15 minutes (P values were 0.01, 0.03, 0.04, and 0.03, respectively). There were no significant differences between two groups in heart rate in different time of study (P>0.05). In the Ephedrine group, the incidence of nausea and vomiting during and after surgery was significantly lower (P values were 0.03, 0.04, 0.04, 0.03, respectively).
Conclusion: At the dose of ephedrine administered in this trial, the ability of this drug to prevent hypotension during percutaneous nephrolithotomy surgery with spinal anesthesia was significant. Higher incidences of hypotension were observed in the placebo group.
Arash Jamalzadeh, Mohadeseh Khakpour, Fatemeh Fardsanei, Farhad Nikkhahi,
Volume 35, Issue 3 (June 2024)
Abstract
Background & Aims: Escherichia coli, a gram-negative bacillus, is one of the most common pathogens causing urinary tract infections. Several studies have demonstrated that the antibiotic fosfomycin has a significant inhibitory effect on Gram-negative pathogens, including Escherichia coli, by inhibiting peptidoglycan production. This study aimed to better understand the effect of fosfomycin against multidrug-resistant Escherichia coli causing urinary tract infections.
Materials and Methods: In this epidemiologic-descriptive study, 90 Escherichia coli isolates were collected between October 1401 and October 1402 from urine samples of teaching hospitals in Qazvin city. ESBL- and AmpC-producing strains were identified using the phenotypic method. Data were evaluated and analyzed using SPSS software version 2022 with a significance level of less than 0.05.
Results: Among the 90 isolates of Escherichia coli, the highest antibiotic resistance was observed for ampicillin (96.6%), cefotaxime (90%), and ceftazidime (84.4%), while the highest susceptibility was related to the antibiotics fosfomycin (98.9%), meropenem (98.8%), gentamicin (88.8%), and nitrofurantoin (84.4%).
Conclusion: With the increase in antibiotic resistance and the spread of strains producing beta-lactamase enzymes, the treatment of infections caused by these strains has become a serious problem. In this study, the susceptibility of Escherichia coli isolates that produce broad-spectrum beta-lactamases and are resistant to multiple drugs to fosfomycin was investigated. It was found that 89 (98.9%) isolates were sensitive to fosfomycin, indicating that fosfomycin is an effective antibiotic against ESBL isolates in Iran.
Shayan Safavi, Melika Peyman Gohar, Mohadeseh Khakpour, Fatemeh Fardsanei, Farhad Nikkhahi,
Volume 35, Issue 5 (August 2024)
Abstract
Background & Aims: Escherichia coli and Klebsiella pneumoniae are important bacteria that cause hospital-acquired infections and have become resistant to beta-lactam antibiotics through the acquisition of beta-lactamase-encoding plasmids. Resistance to disinfectants has also been observed in these strains. Therefore, the aim of this study was to investigate the antimicrobial effect of the disinfectant chlorhexidine on multidrug-resistant strains of Escherichia coli and Klebsiella pneumoniae.
Materials & Methods: Clinical samples were collected from the intensive care unit of Qazvin hospital. All isolates were analysed by phenotypic method. Finally, the combined effect of chlorhexidine and EDTA on the collected strains was performed.
Results: 45% of the 70 Escherichia coli isolates were MDR and 83.3% of the 74 Klebsiella pneumoniae isolates. All samples were equally sensitive to chlorhexidine. EDTA showed no synergistic effect with this substance.
Conclusion: The results of our study show that chlorhexidine can effectively destroy Escherichia coli and Klebsiella pneumoniae producing and non-producing biofilm strains. Therefore, this disinfectant can be used at low concentrations to control antibiotic resistance in multidrug-resistant Escherichia coli and Klebsiella pneumoniae bacteria in hospital-acquired infections.
