Volume 22, Number 3 (Biomonthly July-August 2011) | J Urmia Univ Med Sci 2011, 22(3): 203-211 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Taheraghdam A, Pourkakroudi M, Farhoudi M, Khandaghi R, Ranjbar F, Pourisa M et al . STUDY ON BRAIN ATROPHY AND COGNITIVE IMPAIRMENT IN MS PATIENTS DURING FIRST TWO YEARS OF DISEASE ONSET. J Urmia Univ Med Sci. 2011; 22 (3) :203-211
URL: http://umj.umsu.ac.ir/article-1-988-en.html

Assistant Professor Tabriz University of Medical Sciences , taheraghdam@yahoo.com
Abstract:   (13932 Views)

 Back ground & Aims: Multiple Sclerosis is an inflammatory demyelinating process of central nervous system. The purpose of this study was assessment of brain atrophy and cognitive dysfunction during the first two years of disease evolution.

 Patients and Methods: In a case-control study, 50 cases as patients and 50 normal ones as the control group were included. Twelve patients were male (24%) and 38 were female (76%). The age of cases and controls ones was 15-35. The cases with documented MS of relapsing-remitting type passing the first 2 years of the disease were followed for about 15 months with EDSS and MMSE. MRI films were examined for ICR and then were compared to 50 MRI films of the controls to determine the normal ICR.

 Results: The mean of ICR was 0.107±0.23 in the case group and 0.099±0.21 in the control group that showed no evidence of brain atrophy in patients during the first two years of the disease (P=0.084).

 The relation between MMSE and EDSS of patients was reverse i.e. when MMSE score increased, there was a decrease in the score of EDSS and vice versa.

 Conclusion: In our study, occurrence of brain atrophy during the first two years of RRMS was not observed. However, there was cognitive dysfunction in 46% of patient that presented early onset of cognitive problems in these patients.

  Source: Urmia Med J 2011: 22(3): 277 ISSN: 1027-3727

 

Full-Text [PDF 808 kb]   (1034 Downloads)    
Type of Study: Research | Subject: آناتومی
Received: 2011/07/23

Add your comments about this article : Your username or email:
Write the security code in the box

Send email to the article author


© 2015 All Rights Reserved | URMIA MEDICAL JOURNAL

Designed & Developed by : Yektaweb