Volume 21, Number 3 (Fall 2010)                   J Urmia Univ Med Sci 2010, 21(3): 266-272 | Back to browse issues page


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Moradimoghaddam F, Saadatnia H, Arbabi H. THE CORRELATION BETWEEN ERADICATION OF HELICOBACTER PYLORI AND IMPROVEMENT SYMPTOMS BY FOUR DIFFERENT REGIMES IN PATIENTS WITH CHRONIC DYSPEPSIA. J Urmia Univ Med Sci. 2010; 21 (3) :266-272
URL: http://umj.umsu.ac.ir/article-1-733-en.html

General Physician , moradif@mums.ac.ir
Abstract:   (17578 Views)

  Received: 3 March, 2010 Accepted: 19 May, 2010

  Abstract

  Background & Aims : Chronic dyspepsia is associated with Helicobacter pylori infection and motility disorder.Whether curing the infection actually improves the symptoms or no , remains highly controversial.In this study, we compared four regimes for eradication of H. pylori and its results on improvement of gastrointestinal symptom.

  Materials & Methods : This was a clinical trial which was performed on 160 volunteers from May 2007 to May 2008. Sixty five of them were excluded from our study. Using GIS score, each patient was given a score. In patients with positive Rapid Urease Test, we started the H. Pylori treatment by four regimes (triple therapy for 7 or 10 days, quadruple therapy for 1 or 3 days). The success of the treatment was confirmed by UBT test. In each group the response to treatment was recorded.

  Results : Among 95 cases in this stud y, 10.5 % of the patients received quadruple therapy for one day, 22.1% for 3 days, 42.1% received triple therapy for 7 days, and 25.3% for 10 days. The eradication of H. Pylori was confirmed in 64.3% of the cases by UBT (after 6 weeks). The rate of eradication in 7 and 10 day regimes were 70% and 79.2% and in one and three days regimes were 30% and 61.9% respectively (P=0.041%). The mean GIS recovery score before and after treatment was significant (p=0.03).

  Conclusion : Although GIS score improvement didn't differ significantly in different therapeutic regimes, the best symptom improvement was recorded for patients with successful eradication.

 

  Address : Internal Medicine Department, Ghaem Medical Center Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Tel: 0511-8400000

 

  Email : moradif@mums.ac.ir

 

  Source: Urmia Med J 2010: 21(3): 266 ISSN: 1027-3727

Full-Text [PDF 218 kb]   (958 Downloads)    
Type of Study: Research | Subject: آناتومی
Received: 2010/10/12

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