Volume 20, Issue 4 (winter 2010)                   Studies in Medical Sciences 2010, 20(4): 271-277 | Back to browse issues page

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K Diba, M Geramishoar, M Sharbatkhori, L Hosseinpur. ANTIFUNGAL ACTIVITY OF ALCOHOLIC EXTRACT OF PEGANUM HARMALA IN VITRO. Studies in Medical Sciences 2010; 20 (4) :271-277
URL: http://umj.umsu.ac.ir/article-1-555-en.html
, kadiba@umsu.ac.ir
Abstract:   (23090 Views)

  K Diba [1] , PhD M Geramishoar [2] , MSc M Sharbatkhori [3] , PhD L Hosseinpur [4] , MSc


  Received: 13 Jan, 2009 Accepted: 23 Sep, 2009


 Background & Aims: Regarding the previous studies on anti bacterial and anti parasitic activities of peganum harmala in both traditional and modern uses, comprehensives studies on fungi are necessary. The goal of this study was determination of minimum inhibitory concentration of peganum harmala alcoholic extract on Candida and pathogenic Aspergillus species in vitro.

 Materials & Methods: The study subjects were Candidaspeciesand Aspergillus isolated from clinical specimens. Minimum inhibitory concentrations were determined as the first diluted fungus tube being compared to MCFarland standard 0.5 (without a turbid appearance). In order to detect the minimum fungicidal concentration, a small volume of each treated minimum inhibitory concentration tube was inoculated on Saboroud glucose agar 4%. The first media plate with no growth of fungi was considered as minimum fungicidal concentration.

 Results: Minimum inhibitory concentration was measured on Candida species. As we showed the most significant inhibitory effect of peganum harmala extract detected on Candida tropicalis and Candida glabrata and the lowest inhibitory effect on Candida albicans. The highest fungicidal effect was on Candida glabrata and the less effect on Candida albicans. We could not show a detectable inhibitory and fungicidal effect on Aspergillu species.

 Conclusion: Alcoholic extract of peganum harmala seeds shows inhibitory and fungicidal activity against Candida species.

 Keywords: Peganum harmala, Candida, Inhibitory


 Address: Department of Parasitology and Mycology, Faculty of Medicine, Urmia, Iran
Tel: (+98) 9124464972


 Email: kadiba@umsu.ac.ir


Source: UMJ 2010: 20(4): 332 ISSN: 1027-3727

  [1] Assistant Professor of Medical Mycology, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author)

  [2] Instructor of Parasitology & Mycology, Tehran University of Medical Sciences, Tehran, Iran

  [3] Assistant Professor of Parasitology, Gorgan University of Medical Sciences, Gorgan, Iran

  [4] Master of Parasitology & Mycology, Tehran University of Medical Sciences, Tehran, Iran

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Type of Study: Research | Subject: آناتومی

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