Background & Aims: Different hormonal responses may appear in severe head injured patients. These changes can also be seen in recovery and rehabilitation periods, so influencing the patients, outcome. This study compared changes in thyroid hormones in patients undergoing craniotomy have been due to a severe head injury with craniotomy patients have not been done.

 Materials & Methods: In this clinical trial, 59 patients following severe brain injury (GCS ≤ 8) were admitted to Ahwaz Golestan Hospital neurosurgery service and were studied regarding inclusion and exclusion criteria. The patients were divided into two groups of 27 patients. The first group patients who had focal lesions underwent brain surgery craniotomy. First test was taken 24 hours and second sample was taken after day 5. The serum sample was tested using ELISA and human fully automatic machines. The data were analyzed with SPSS software and using independent t-test, Pearson correlation coefficient (P <0.05)

 Results: The mean serum T3 and TSH levels in patients with severe head trauma craniotomy showed statistically no significant differences compared with patients who had no craniotomy. And there was no connection between relief and serum levels of these variables. There were relationships between healing and T4 levels in both groups of patients.

 Conclusion: The results of this study showed that craniotomy surgery was effective in improving patients with severe head trauma and hormone thyroxine (T4) was used as a prognostic factor in these patients.

  SOURCE: URMIA MED J 2014: 25(3): 198 ISSN: 1027-3727