Studies in Medical Sciences
مجله مطالعات علوم پزشکی
Studies in Medical Sciences
Medical Sciences
http://umj.umsu.ac.ir
37
journal37
2717-008X
2717-008X
10.61186/umj
fa
jalali
1396
4
1
gregorian
2017
7
1
28
4
online
1
fulltext
en
Association of CFI gene polymorphism with age related macular degeneration in Northwest of Iran
Association of CFI gene polymorphism with age related macular degeneration in Northwest of Iran
ژنتیک
ژنتیک
پژوهشي(توصیفی- تحلیلی)
Research
<p style="text-align:justify;line-height:18.0pt;"><a name="_Toc416081061"><strong><em><span style="font-size:9.0pt;">Background & Aims:</span></em></strong></a><span style="font-size:9.0pt;"> To investigate the association of <em>CFI</em> p.Gly119Arg</span> <span style="font-size:9.0pt;">polymorphism with Age-related macular degeneration (AMD).</span></p>
<p style="text-align:justify;line-height:18.0pt;"><strong><em><span style="font-size:9.0pt;">Materials & Methods:</span></em></strong><span style="font-size:9.0pt;"> In this case-control study, the association of p.Gly119Arg polymorphism in <em>CFI </em>gene was investigated in 65 patients suffering from AMD and150 healthy age, sex and ethnicity matched unrelated people as control group. Both of the case and control groups were originated from Northwest of Iran. Genotypes of both groups were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).</span></p>
<p style="text-align:justify;line-height:18.0pt;"><strong><em><span style="font-size:9.0pt;">Results:</span></em></strong><span style="font-size:9.0pt;"> Investigation of the association of p.Gly119Arg polymorphism in <em>CFI</em> gene with AMD showed that there are no statistically significant differences between patients and controls in genotype and allele frequencies of this polymorphism (P˃0/05).</span></p>
<p style="text-align:justify;line-height:18.0pt;"><strong><em><span style="font-size:9.0pt;">Conclusion:</span></em></strong><span style="font-size:9.0pt;"> Our result show that p.Gly119Arg</span> <span style="font-size:9.0pt;">polymorphism of the <em>CFI</em> gene is unrelated to the susceptibility to AMD in Northwest of Iran.</span></p>
<p><a name="_Toc416081061"><strong><em>Background & Aims:</em></strong></a> To investigate the association of <em>CFI</em> p.Gly119Arg polymorphism with Age-related macular degeneration (AMD).</p>
<p><strong><em>Materials & Methods:</em></strong> In this case-control study, the association of p.Gly119Arg polymorphism in <em>CFI </em>gene was investigated in 65 patients suffering from AMD and150 healthy age, sex and ethnicity matched unrelated people as control group. Both of the case and control groups were originated from Northwest of Iran. Genotypes of both groups were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).</p>
<p><strong><em>Results:</em></strong> Investigation of the association of p.Gly119Arg polymorphism in <em>CFI</em> gene with AMD showed that there are no statistically significant differences between patients and controls in genotype and allele frequencies of this polymorphism (P˃0/05).</p>
<p><strong><em>Conclusion:</em></strong> Our result show that p.Gly119Arg polymorphism of the <em>CFI</em> gene is unrelated to the susceptibility to AMD in Northwest of Iran.</p>
AMD , پلی مورفیسم ,ژن CFI
AMD, polymorphism, CFI gene
16
21
http://umj.umsu.ac.ir/browse.php?a_code=A-10-2602-1&slc_lang=en&sid=1
neda
norouzi
neda
norouzi
n.norouzi67@yahoo.com
3700319475328460018638
3700319475328460018638
No
Tabriz University
Tabriz University
Mortaza
Bonyadi
Mortaza
Bonyadi
jabbarpour@tabrizu.ac.ir
3700319475328460018639
3700319475328460018639
Yes
Tabriz of University
Tabriz of University
Esmaeil
Babaei
Esmaeil
Babaei
babaei@tabrizu.ac.ir
3700319475328460018640
3700319475328460018640
No
Tabriz of University
Tabriz of University
Mohammad Hossein
Jabbarpour Bonyadi
Mohammad Hossein
Jabbarpour Bonyadi
3700319475328460018641
3700319475328460018641
No
Ophthalmic Research Center Shaheed Beheshti University of Medical Sciences & Health Services, Tehran, Iran
Ophthalmologist, Ophthalmic Research Center Shaheed Beheshti University of Medical Sciences & Health Services, Tehran, Iran
AliReza
Javadzadeh
AliReza
Javadzadeh
3700319475328460018642
3700319475328460018642
No
Tabriz University of Medical Scinces
Tabriz University of Medical Scinces