fa تعیین ارتباط یافته‌های VEP و SSEP باوجود دمانس در بیماران مبتلا به بیماری پارکینسون آناتومی آناتومی پژوهشي(توصیفی- تحلیلی) Research <p class="Chekide" style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><b><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">پیش‌زمینه و هدف:</span></b><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt"> </span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">پارکینسونیسم در تمام نژادها رخ می‌دهد. شیوع آن در ایالات‌متحده و اروپای غربی 2-1 نفر در هر 1000 نفر هست. </span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">حدود</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">یک‌سوم</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">بیماران</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">مشکلات</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">شناختی</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">عمده</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">دارند</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">که اغلب</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">پس</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">از چهار</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">سال</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">دو</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">برابر</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">می‌شود</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">و</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">دمانس</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">در 80درصد بیماران</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">مبتلا</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">به</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">پارکینسون</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">در</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">مراحل</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">پایانی</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">بیماری</span><span dir="ltr"></span><span lang="AR-SA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">دیده می‌شود. هدف از این مطالعه </span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">تعیین ارتباط یافته‌های </span><font size="2"><font face="Times New Roman"><span dir="ltr">VEP</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> و </span><font size="2"><font face="Times New Roman"><span dir="ltr">SSEP</span><span dir="rtl"></span></font></font><span style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> <span lang="FA"><font size="2"><font face="Nazanin">باوجود دمانس در بیماران مبتلا به بیماری پارکینسون بود.<p></p></font></font></span></span></p><p class="Chekide" style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><b><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">مواد و روش‌ها: </span></b><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">در یک مطالعه مورد شاهدی که در دپارتمان بیماری‌های اعصاب دانشگاه علوم پزشکی تبریز بر روی بیماران مبتلا به </span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">پارکینسون انجام دادیم، ارتباط یافته‌های </span><font size="2"><font face="Times New Roman"><span dir="ltr">VEP</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> و </span><font size="2"><font face="Times New Roman"><span dir="ltr">SSEP</span><span dir="rtl"></span></font></font><span style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> <span lang="FA"><font size="2"><font face="Nazanin">باوجود دمانس در بیماران مبتلا به بیماری پارکینسون موردبررسی قرار دادیم.<p></p></font></font></span></span></p><p class="Chekide" style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><b><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">ِیافته‌ها و نتیجه‌گیری: </span></b><font size="2"><font face="Times New Roman"><span dir="ltr">VEP AMP</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> سمت راست در 12 نفر از بیماران غیرطبیعی و </span><font size="2"><font face="Times New Roman"><span dir="ltr">VEP AMP</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> سمت چپ در 13 نفر از بیماران غیرطبیعی بود.<p></p></span></p><p class="Chekide" style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">رابطه خطی معنی‌داری بین امتیاز </span><font size="2"><font face="Times New Roman"><span dir="ltr">MMSE</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> بیماران با میزان </span><span dir="ltr"><font face="Times New Roman" size="2">VEP P100 </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">سمت راست و چپ میزان </span><span dir="ltr"><font face="Times New Roman" size="2">VEP AMP </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">سمت راست و چپ، میزان </span><font size="2"><font face="Times New Roman"><span dir="ltr">Ssep P40</span><span dir="rtl"></span></font></font><span style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> <span lang="FA"><font face="Nazanin" size="2">سمت راست، میزان </font></span></span><font size="2"><font face="Times New Roman"><span dir="ltr">Ssep AMP </span><span dir="rtl"></span></font><span style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span><font face="Nazanin"><span style="mso-spacerun: yes"> </span><span lang="FA">سمت راست وجود نداشت ولی رابطه خطی معنی‌دار معکوسی بین امتیاز </span></font></span><font face="Times New Roman"><span dir="ltr">MMSE</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> بیماران با میزان </span><span dir="ltr"><font face="Times New Roman" size="2">Ssep P40 </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">سمت چپ و میزان </span><font size="2"><font face="Times New Roman"><span dir="ltr">Ssep AMP </span><span dir="rtl"></span></font><span style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span><font face="Nazanin"><span style="mso-spacerun: yes"> </span><span lang="FA">سمت چپ بیماران موردمطالعه <a name="_GoBack"></a>وجود داشت.<p></p></span></font></span></font></p><p class="Chekide" style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">میانگین </span><font size="2"><font face="Times New Roman"><span dir="ltr">VEP P100</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> سمت راست در بیماران موردمطالعه 18/24 ± 104 و میانگین </span><font size="2"><font face="Times New Roman"><span dir="ltr">VEP P100</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> سمت چپ در بیماران موردمطالعه 60/24 ± 94/104 بود و همچنین </span><font size="2"><font face="Times New Roman"><span dir="ltr">VEP P100</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> سمت راست و چپ بیماران در 24 نفر (40درصد) از بیماران غیرطبیعی بود.<p></p></span></p><p class="Chekide" style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">تفاوت معنی‌داری بین میانگین </span><font size="2"><font face="Times New Roman"><span dir="ltr">P100 Latency</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> بیماران با و بدون اختلال وجود نداشت. تفاوت معنی‌داری بین آمپلی تود </span><font size="2"><font face="Times New Roman"><span dir="ltr">Ssep</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> بیماران مبتلا به پارکینسون با و بدون اختلال عملکردی وجود نداشت.<p></p></span></p><p class="Chekide" style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl" ><p class="Chekide" style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><p> </p></span></p> <p class="Abstract" style="MARGIN: 0in 0in 0pt"><p><strong><font face="Times New Roman" size="3"> </font></strong></p></p><p class="Amatnmagale" style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt"><font size="3"><font face="Times New Roman"><i><strong>Background & Aims</strong></i>: Parkinsonism occurs in all races. Its prevalence in the <country-region w:st="on">United States</country-region> and <place w:st="on">Western Europe</place> is 2.1 persons per 1,000 populations. Approximately one third of patients have cognitive problems that often doubles after 4 years in 80% of patients with dementia and Parkinson’s disease (PD) occurs in the final stages. The aim of this study was to determine the relationship between visual evoked potential (VEP) and Somatosensory evoked potential (SSEP) findings in patients with Parkinson’s disease with dementia.<span lang="AR-SA" dir="rtl"><p></p></span></font></font></p><p class="Amatnmagale" style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt"><font size="3"><font face="Times New Roman"><b><i>Materials & Methods</i></b>: <span style="COLOR: black mso-bidi-language: FA">In a case-control study that performed in neurology department of Tabriz University of medical sciences on patients with PD, the </span>relationship between VEP and SSEP findings in patients with Parkinson's disease with dementia evaluated.</font></font></p><p class="Amatnmagale" style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt"><font size="3"><font face="Times New Roman"><b><i>Results</i></b><span style="COLOR: black mso-bidi-language: FA">: Right VEP denotes AMP in 12 was abnormal and left VEP denote AMP was abnormal in 13 patients. No significant correlation line was found between MMSE score with left and right VEP 100, Left and right VEP AMP, right SSEP P40 and SSEP AMP but there was a significant line correlation between MMSE score with left SESEP and SSEP P40.<p></p></span></font></font></p><p class="Amatnmagale" style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt"><span style="COLOR: black mso-bidi-language: FA"><font size="3"><font face="Times New Roman">Mean right VEP P100 was 104 + 24.18 and mean left VEP P100 was 104.94 + 24 and also, left and right VEP P100 were abnormal in 24(40). <p></p></font></font></span></p><p class="Amatnmagale" style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt"><font size="3"><font face="Times New Roman"><b><i>Conclusion</i></b><span style="COLOR: black mso-bidi-language: FA">: There was no significant difference in mean of P100 Latency in patients with and without functional disorder. No significant difference was observed between patients with Parkinson’s SSEP AMP with and without functional impairment.</span></font></font></p><p align="center" class="Amatnmagale" style="TEXT-ALIGN: center MARGIN: 0in 0in 0pt"><p><font face="Times New Roman" size="3"> </font></p></p><p align="center" class="Amatnmagale" style="TEXT-ALIGN: center MARGIN: 0in 0in 0pt"><font size="3"><font face="Times New Roman">SOURCE: URMIA MED J 2014: 25(9): 802 ISSN: 1027-3727<span style="mso-bidi-language: FA"><p></p></span></font></font></p> پارکینسون, دمانس, VEP, Ssep Parkinson’s disease, Dementia, Visual evoked potential, Somatosensory evoked potential 791 802 http://umj.umsu.ac.ir/browse.php?a_code=A-10-582-527&slc_lang=fa&sid=1 Mohammad Yazdchi محمد یزدچی 3700319475328460010595 3700319475328460010595 No Neurology Department, Faculty of Medicine, Tabriz University of Medical Sciences دپارتمان اعصاب، دانشکده پزشکی، داتشگاه علوم پزشکی تبریز Mahnaz Talebi مهناز طالبی 3700319475328460010596 3700319475328460010596 No Neurology Department, Faculty of Medicine, Tabriz University of Medical Sciences دپارتمان اعصاب، دانشکده پزشکی، داتشگاه علوم پزشکی تبریز Safa Najmi صفا نجمی 3700319475328460010597 3700319475328460010597 No Neurology Department, Faculty of Medicine, Tabriz University of Medical Sciences دپارتمان اعصاب، دانشکده پزشکی، داتشگاه علوم پزشکی تبریز Afshin Mardani افشین مردانی mashrabi1383@yahoo.com 3700319475328460010598 3700319475328460010598 Yes Neurology Department, Faculty of Medicine, Tabriz University of Medical Sciences دپارتمان اعصاب، دانشکده پزشکی، داتشگاه علوم پزشکی تبریز Ehsan Sharifipoor احسان شریفی پور 3700319475328460010599 3700319475328460010599 No Neurology Department, Faculty of Medicine, Tabriz University of Medical Sciences دپارتمان اعصاب، دانشکده پزشکی، داتشگاه علوم پزشکی تبریز Omid Mashrabi امید مشربی 3700319475328460010600 3700319475328460010600 No Neurology Department, Faculty of Medicine, Tabriz University of Medical Sciences دپارتمان اعصاب، دانشکده پزشکی، داتشگاه علوم پزشکی تبریز