%0 Journal Article %A Nabilpour, Maghsoud %A Sadeghi, Abbas %A Seifi, Farnaz %T THE EFFECT OF TWO MONTHS OF CHIA SUPPLEMENTATION ON INFLAMMATORY AND ANTI-INFLAMMATORY RESPONSES IN WISTAR DIABETIC MALE RATS %J Studies in Medical Sciences %V 32 %N 2 %U http://umj.umsu.ac.ir/article-1-5111-en.html %R %D 2021 %K Interleukin-1 beta, Interleukin-13, Herbal Supplements, Inflammation, Anti-Inflammatory Agents, %X Background & Aims: Increased inflammation is a consequence of diabetes. Accordingly, the use of herbal medicine as a solution has been suggested. The objective of this study was to evaluate the effect of two months of chia supplementation in conjunction with inflammatory and anti-inflammatory responses in male Wistar diabetic rats. Materials & Methods: 36 diabetic rats were randomly assigned to 3 equal groups (control group, diabetes group, diabetes + chia group) and were subjected to 8 weeks of supplementation. Interleukin-1 and interleukin-13 were measured in soleus muscle tissue to examine the inflammatory and anti-inflammatory indicators. ANOVA and Tukey's post hoc test were used for data analysis. Results: Although chia supplementation had aggravating effects on IL-1ß compared with the diabetic group, this effect was not statistically significant (p = 0.99). Also, IL-13 protein expression increased significantly in the diabetic control group by about 51% (p = 0.001), and in the diabetic group with chia supplementation by about 50% (p= 0.001) compared to the healthy control group. There was no significant difference between the two groups. Conclusion: It seems that two months of chia supplementation with this dose and period of consumption could not have a positive effect on anti-inflammatory factors in male diabetic rats. Confirmation of this finding requires further research in this area. %> http://umj.umsu.ac.ir/article-1-5111-en.pdf %P 116-123 %& 116 %! %9 Research %L A-10-2426-4 %+ Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran (Corresponding Author) %G eng %@ 2717-008X %[ 2021