Volume 32, Issue 9 (December 2021)                   Studies in Medical Sciences 2021, 32(9): 667-673 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

URL: http://umj.umsu.ac.ir/article-1-5612-en.html
Subspecialty perinatology, Maternal and Child Obesity Research Center, Urmia University of Medical Sciences, Urmia. Iran (Corresponding author) , shabnam.vazifekhah@yahoo.com
Abstract:   (1156 Views)
Background & Aims: Early diagnosis of gestational diabetes and subsequent treatment plays a vital role in preventing the consequences of pregnancy. According to the results of previous studies about the increase in amniotic fluid glucose levels following gestational diabetes, this study aimed to determine the relationship between amniotic fluid glucose level and maternal BMI, fetal birth weight, and maternal blood glucose in mothers undergoing second-trimester genetic amniocentesis.
Materials & Methods: This study is a prospective cohort design performed on 115 pregnant women who underwent amniocentesis in the second-trimester of pregnancy at Kowsar Obstetrics and Gynecology Center. Data were collected using a checklist that assesses the initial demographic characteristics of individuals, including maternal age, severity, parity, gestational age, maternal weight and height, BMI, macrosomic birth history, history of preterm delivery, and abortion. The validity and reliability of the checklist were previously confirmed by the professors of the obstetrics and gynecology and Cronbach's alpha coefficient.
Results: The results of the present study showed that amniotic fluid glucose has a positive and significant correlation with age, fasting blood sugar, amniotic fluid volume, and birth weight of the fetus. Also, pregnant mothers with gestational diabetes had higher fasting blood sugar, fetal birth weight, amniotic fluid volume, and amniotic fluid glucose and had a significant difference with non-patients.
Conclusion: With all the limitations of the present study, the results showed that amniotic fluid glucose could be used as a factor in the follow-up and consideration of pregnant mothers for gestational diabetes and fetal birth weight.
Full-Text [PDF 540 kb]   (242 Downloads)    
Type of Study: Research | Subject: زنان و زایمان

1. Bloomfield FH, Jaquiery AL, Oliver MH. Nutritional regulation of fetal growth. In: Maternal and Child Nutrition: The First 1,000 Days. Karger Publishers; 2013. p. 79-89. [DOI:10.1159/000348405] [PMID]
2. Wu Y, Liu B, Sun Y, Du Y, Santillan MK, Santillan DA, et al. Association of maternal prepregnancy diabetes and gestational diabetes mellitus with congenital anomalies of the newborn. Diabetes Care 2020;43(12):2983-90. [DOI:10.2337/dc20-0261] [PMID] [PMCID]
3. Chitayat L, Zisser H, Jovanovič L. Continuous glucose monitoring during pregnancy. Diabetes technology & therapeutics 2009;11(S1):S-105. [DOI:10.1089/dia.2008.0136] [PMID]
4. Hanprasertpong T, Kor-Anantakul O, Suwanrath C, Suntharasaj T, Pruksanusak N, Hanprasertpong J, et al. Subsequent gestational diabetes mellitus prediction in advanced maternal age using amniotic fluid glucose concentration during second trimester genetic amniocentesis. J Obstet Gynaecol2016;36(6):744-7. [DOI:10.3109/01443615.2016.1150261] [PMID]
5. Zalak K, Kazemi Haki B, Matlabi H. Obstacles to Self-Care From The Viewpoint of TypeII Diabetic Patients and Guidelines to Remove Them. Jorjani Biomed J 2012; 1 (1):30-7. [Google Scholar]
6. Fruscalzo A, Londero AP, Biasizzo J, Curcio F, Bertozzi S, Marchesoni D, et al. Second trimester maternal plasma and amniotic fluid adipokines in women who will develop gestational diabetes mellitus. Gynecol Endocrinol2015;31(12):934-8. [DOI:10.3109/09513590.2015.1079611] [PMID]
7. Eades CE, Cameron DM, Evans JM. Prevalence of gestational diabetes mellitus in Europe: A meta-analysis. Diabetes Res Clin Pract2017;129:173-81. [DOI:10.1016/j.diabres.2017.03.030] [PMID]
8. O'Neill K, Alexander J, Azuma R, Xiao R, Snyder NW, Mesaros CA, et al. Gestational diabetes alters the metabolomic profile in 2nd trimester amniotic fluid in a sex-specific manner. Int J Mol Sci2018;19(9):2696. [DOI:10.3390/ijms19092696] [PMID] [PMCID]
9. Parveen R, Ahmed A, Mohiuddin AS, Rahman SS, Paul TK. Correlation between amniotic fluid index and estimated fetal weight in third trimester of pregnancy. Bangladesh Medical Journal 2011;40(3):21-3. [DOI:10.3329/bmj.v40i3.18669]
10. Bhagat M, Chawla I. Correlation of amniotic fluid index with perinatal outcome. J Obstet Gynaecol India 2014;64(1):32-5. [DOI:10.1007/s13224-013-0467-2] [PMID] [PMCID]
11. Rinala SG, Dryfhout VL, Lambers DS. Correlation of glucose concentrations in maternal serum and amniotic fluid in high-risk pregnancies. Am J Obstet Gynecol 2009;200(5):e43-e4. [DOI:10.1016/j.ajog.2008.10.046] [PMID]
12. Orczyk-Pawilowicz M, Jawien E, Deja S, Hirnle L, Zabek A, Mlynarz P. Metabolomics of human amniotic fluid and maternal plasma during normal pregnancy. PloS one 2016;11(4):e0152740. [DOI:10.1371/journal.pone.0152740] [PMID] [PMCID]
13. Star J, Canick JA, Palomaki GE, Carpenter MW, Saller DN Jr, Sung CJ, et al. The relationship between second-trimester amniotic fluid insulin and glucose levels and subsequent gestational diabetes. Prenat Diagn 1997;17(2):149-54. https://doi.org/10.1002/(SICI)1097-0223(199702)17:2<149::AID-PD48>3.0.CO;2-S [DOI:10.1002/(SICI)1097-0223(199702)17:23.0.CO;2-S]
14. Dashe JS, Nathan L, McIntire DD, Leveno KJ. Correlation between amniotic fluid glucose concentration and amniotic fluid volume in pregnancy complicated by diabetes. Am J Obstet Gynecol2000;182(4):901-4. [DOI:10.1016/S0002-9378(00)70343-7]
15. Bicocca MJ, Qureshey EJ, Chauhan SP, Hernandez‐Andrade E, Sibai BM, Nowlen C, et al. Semiquantitative Assessment of Amniotic Fluid Among Individuals With and Without Diabetes Mellitus. J Ultrasound Med 2022;41(2):447-55. [DOI:10.1002/jum.15725] [PMID]
16. Majidi S, Haki BK, Matlabi H. Factors Affecting Blood Pressure in Women with Hypertension Who Were Referred to Beyrag Health House-Tabriz 1391. Depiction of Health 2013;4(1):21-6. [Google Scholar]
17. Sane S, Mahdkhah A, Golabi P, Hesami SA, Kazemi Haki B. Comparison the effect of bupivacaine plus magnesium sulfate with ropivacaine plus magnesium sulfate infiltration on postoperative pain in patients undergoing lumbar laminectomy with general anesthesia. Br J Neurosurg2020:1-4. [DOI:10.1080/02688697.2020.1861430] [PMID]

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Studies in Medical Sciences

Designed & Developed by : Yektaweb