Volume 33, Issue 9 (December 2022)
Studies in Medical Sciences 2022, 33(9): 646-651 |
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Miri-Aliabad G, Khajeh A, Safapour S. HEMATOLOGICAL PARAMETERS AND FERRITIN LEVEL IN CHILDREN WITH VITAMIN D DEFICIENCY. Studies in Medical Sciences 2022; 33 (9) :646-651
URL: http://umj.umsu.ac.ir/article-1-5367-en.html
URL: http://umj.umsu.ac.ir/article-1-5367-en.html
Associate Professor of Pediatrics, member of Child and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran (corresponding Author) , drkhajehneuro@gmail.com
Abstract: (928 Views)
Background & Aim: Iron and vitamin D are considered as two essential micronutrients for growth and development of the children. Vitamin D and iron deficiencies in children are associated with many adverse effects and significant morbidity. This study aimed to investigate of hematological parameters and serum ferritin level in children with vitamin D deficiency.
Materials & Methods: The present study was a case-control one that was conducted on 100 children aged 2 to 18 in two groups (50 each) of with vitamin D deficiency and control group.
Complete blood count (CBC) and serum ferritin level were measured using Sysmex KX-21N cell counter and ELISA method in both groups. The data was analyzed using SPSS version 20 and the results obtained in the two groups were compared. P values<0.05 were considered statistically significant.
Results: The mean age of children in the group with vitamin D deficiency was 5.6±4.1 and in the control group was 4.9±3.3 years (P=0.34). In the vitamin D deficiency group, 66% were boys but in the control group, 54% were boys (P=0.22). The mean serum level of hemoglobin (P=0.22) and the mean corpuscular volume (MCV) (P=0.76) as well as the mean red blood cell count (P=0.25) were not significantly different between the two groups. However, the mean serum ferritin level in the group with vitamin D deficiency was significantly lower than the control group (P=0.03).
Conclusion: The results of the present study showed that the serum level of ferritin in the group with vitamin D deficiency is lower than the control group, and the level of vitamin D has a significant positive correlation with the level of ferritin in these children. Therefore, it is suggested to evaluate anemia and ferritin in the children with vitamin D deficiency. Also, providing sufficient amount of vitamin D may play an important role in preventing anemia in the children.
Materials & Methods: The present study was a case-control one that was conducted on 100 children aged 2 to 18 in two groups (50 each) of with vitamin D deficiency and control group.
Complete blood count (CBC) and serum ferritin level were measured using Sysmex KX-21N cell counter and ELISA method in both groups. The data was analyzed using SPSS version 20 and the results obtained in the two groups were compared. P values<0.05 were considered statistically significant.
Results: The mean age of children in the group with vitamin D deficiency was 5.6±4.1 and in the control group was 4.9±3.3 years (P=0.34). In the vitamin D deficiency group, 66% were boys but in the control group, 54% were boys (P=0.22). The mean serum level of hemoglobin (P=0.22) and the mean corpuscular volume (MCV) (P=0.76) as well as the mean red blood cell count (P=0.25) were not significantly different between the two groups. However, the mean serum ferritin level in the group with vitamin D deficiency was significantly lower than the control group (P=0.03).
Conclusion: The results of the present study showed that the serum level of ferritin in the group with vitamin D deficiency is lower than the control group, and the level of vitamin D has a significant positive correlation with the level of ferritin in these children. Therefore, it is suggested to evaluate anemia and ferritin in the children with vitamin D deficiency. Also, providing sufficient amount of vitamin D may play an important role in preventing anemia in the children.
Type of Study: Research |
Subject:
کودکان (عمومی)
References
1. Christian P, Tielsch JM. Evidence for multiple micronutrient effects based on randomized controlled trials and meta-analyses in developing countries. J Nutr 2012;142:173S-7S. [DOI:10.3945/jn.111.149898] [PMID]
2. Beard JL. Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr 2001;131:568S-79S. [DOI:10.1093/jn/131.2.568S] [PMID]
3. Aggett PJ, Agostoni C, Axelsson I, Bresson JL, Goulet O, Hernell O, et al. Iron metabolism and requirements in early childhood: do we know enough?: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 2002;34:337-45. [DOI:10.1097/00005176-200204000-00003] [PMID]
4. Balasubramanian S. Vitamin D deficiency in breastfed infants & the need for routine vitamin D supplementation. Indian J Med Res 2011;133:250-2. [PMCID]
5. Blazsek I, Farabos C, Quittet P, Labat ML, Bringuier AF, Triana BK, et al. Bone marrow stromal cell defects and 1 alpha, 25-dihydroxyvitamin D3 deficiency underlying human myeloid leukemias. Cancer Detect Prev 1996;20:31-42. [Google Scholar]
6. Aucella F, Scalzulli RP, Gatta G, Vigilante M, Carella AM, Stallone C. Calcitriol increases burst-forming unit-erythroid proliferation in chronic renal failure, a synergistic effect with r- HuEpo. Nephron Clin Pract 2003;95:c121-c127. [DOI:10.1159/000074837] [PMID]
7. Sharma S, Jain R, Dabla PK. The role of 25-hydroxy vitamin D deficiency in iron deficient children of North India. Indian J Clin Biochem 2015;30(3):313-7. [DOI:10.1007/s12291-014-0449-x] [PMID] [PMCID]
8. Yoon JW, Kim SW, Yoo EG, Kim MK. Prevalence and risk factors for vitamin D deficiency in children with iron deficiency anemia. Korean J Pediatr 2012;55(6):206-11. [DOI:10.3345/kjp.2012.55.6.206] [PMID] [PMCID]
9. Sim JJ, Lac PT, Liu IL, Meguerditchian SO, Kumar VA, Kujubu DA, et al. Vitamin D deficiency and anemia: a cross-sectional study. Ann Hematol 2010;89(5):447-52. [DOI:10.1007/s00277-009-0850-3] [PMID] [PMCID]
10. Qader EA, Alkhateeb NE. Vitamin D Status in Children with Iron Deficiency and/or Anemia Int J Pediatr 2016; 4(9):3571-7. [Google Scholar]
11. Ganiger A, Swamy KM, Shankar Prasad DS, Kashinakunti SV. Study of Serum 25-Hydroxy Vitamin D Levels in Anemia-A Case Control Study. Int J Contemp Med Res 2016; 3(3):678-81. [Google Scholar]
12. Monlezun DJ, Camargo Jr CA, Mullen JT, Quraishi SA. Vitamin D Status and the Risk of Anemia in Community-Dwelling Adults: Results from the National Health and Nutrition Examination Survey 2001-2006. Medicine 2015;94(50). [DOI:10.1097/MD.0000000000001799] [PMID] [PMCID]
13. Lee JA, Hwang JS, Hwang IT, Kim DH, Seo JH, Lim JS. Low vitamin D levels are associated with both iron deficiency and anemia in children and adolescents. Pediatr Hematol Oncol 2015;32(2):99-108. [DOI:10.3109/08880018.2014.983623] [PMID]
14. Perlstein TS, Pande R, Berliner N, Vanasse GJ. Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation. Blood 2011;117(10):2800-6. [DOI:10.1182/blood-2010-09-309708] [PMID]
15. Azizi-Soleiman F, Vafa M, Abiri B, Safavi M. Effects of iron on Vitamin D metabolism: A systematic review. Int J Prev Med 2016;7(1):126-32. [DOI:10.4103/2008-7802.195212] [PMID] [PMCID]
16. Liu T, Zhong S, Liu L, Liu S, Li X, Zhou T, Zhang J. Vitamin D deficiency and the risk of anemia: a meta-analysis of observational studies. Renal failure 2015;37(6):929-34.Smith EM, Tangpricha V. Vitamin D and anemia: insights into an emerging association. Curr Opin Endocrinol Diabetes Obes 2015;22(6):432-8 [DOI:10.1097/MED.0000000000000199] [PMID] [PMCID]
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