Volume 32, Issue 4 (July 2021)                   Studies in Medical Sciences 2021, 32(4): 273-279 | Back to browse issues page

XML Persian Abstract Print

Bone and joint reconstruction research center, Shafa orthopedic hospital, Iran University of medical science, Tehran, Iran (Corresponding Author) , miladbahari@ymail.com
Abstract:   (2202 Views)
Background & Aims: Chronic kidney disease is commonly seen with reduced calcium and low-energy fractures. In this study, we investigated the relationship between estimated Glomerular Filtration Rate (eGFR) and low-energy hip fractures.
Materials & Methods: This cross-sectional study was performed on patients with renal insufficiency who were referred to Alzahra and Kashani hospitals with a diagnosis of hip fracture in 2016 and 2017. Cr level was extracted from the patient file and the relationship between eGFR and other variables was investigated.
Results: Of the studied patients, 203 (48.6%) had eGFR below 60 and 215 (51.4%) had eGFR above 60. Female patients with e-GFR below 60 were more common, underlying diseases of diabetes and hypertension were significantly higher in e-GFR below 60, and mean age and creatinine levels in e-GFR below 60 were significantly higher than eGFR above 60. The mean hemoglobin level in subjects with eGFR below 60 was significantly lower than those with eGFR above 60 (p <0.05). Mortality was significantly higher in subjects with eGFR below 60 than in those with eGFR above 60. There was no significant relationship between eGFR and type of fracture and ischemia (p> 0.05).
Conclusion: Management in the prevention of hip fracture and treatment of patients with renal failure can be effective in the treatment of fracture and reducing its mortality.
Full-Text [PDF 466 kb]   (634 Downloads)    
Type of Study: Research | Subject: Orthopedic

1. Laulund AS, Lauritzen JB, Duus BR, Mosfeldt M, Jørgensen HL. Routine blood tests as predictors of mortality in hip fracture patients. Injury 2012;43:1014-20. [DOI:10.1016/j.injury.2011.12.008] [PMID]
2. Nickolas TL, Stein EM, Dworakowski E, Nishiyama KK, Komandah-Kosseh M, Zhang CA, et al.Rapid cortical bone loss in patients with chronic kidney disease. J Bone Miner Res 2013;28(8):1811-20. [DOI:10.1002/jbmr.1916] [PMID] [PMCID]
3. Ersoy FF. Osteoporosis in the elderly with chronic kidney disease. Int Urol Nephrol 2007;39:321-31. [DOI:10.1007/s11255-006-9109-2] [PMID]
4. Ensrud KE, Parimi N, Fink HA, Ishani A, Taylor BC, Steffes M, et al. Estimated GFR and Risk of Hip Fracture in Older Men:Comparison of Associations Using Cystatin C and Creatinine. Am J Kidney Dis 2014;63(1):1-16. [DOI:10.1053/j.ajkd.2013.05.022] [PMID] [PMCID]
5. Dooley AC, Weiss NS, Kestenbaum B. Increased Risk of Hip Fracture Among Men With CKD. Am J Kidney Dis 2007;51:38-44. [DOI:10.1053/j.ajkd.2007.08.019] [PMID]
6. Yenchek RH, Ix JH, Shlipak MG, Bauer DC, Rianon NJ, Kritchevsky SB, et al.Bone Mineral Density and Fracture Risk in Older Individuals with CKD. Clin J Am Soc Nephrol 2012;7:1130-6. [DOI:10.2215/CJN.12871211] [PMID] [PMCID]
7. Seliger SL, Zhan M, Hsu VD, Walker LD, Fink JC. Chronic Kidney Disease Adversely Influences Patient Safety. J Am Soc Nephrol 2008;19:2414-9. [DOI:10.1681/ASN.2008010022] [PMID] [PMCID]
8. Najar MS, Mir MM, Muzamil M. Prevalence of Osteoporosis in Patients with Chronic Kidney Disease (Stages 3-5) in Comparison with Age- and Sex-matched Controls: A Study from Kashmir Valley Tertiary Care Center. Saudi J Kidney Dis Transpl 2017;28(3):538-44. [DOI:10.4103/1319-2442.206439] [PMID]
9. Nickolas TL, McMahon DJ, Shane E. Relationship between Moderate to Severe Kidney Disease and Hip Fracture in the United States. J Am Soc Nephrol 2006;17: 3223-32. [DOI:10.1681/ASN.2005111194] [PMID]
10. Pérez-Sáez MJ, Prieto-Alhambra D, Barrios C, Crespo M, Redondo D, Nogués X, et al. Increased hip fracture and mortality in chronic kidney disease individuals: The importance of competing risks. Bone 2015;73:154-9. [DOI:10.1016/j.bone.2014.12.020] [PMID]
11. Kuo LT, Lin SJ, Hsu WH, Peng KT, Lin CL, Hsu RW. The effect of renal function on surgical outcomes of intracapsular hip fractures with osteosynthesis. Arch Orthop Trauma Surg 2014 134:39-45. [DOI:10.1007/s00402-013-1884-5] [PMID]
12. Nitsch D, Mylne A, Roderick PJ, Smeeth L, Hubbard R, Fletcher A. Chronic kidney disease and hip fracture-related mortality in older people in the UK. Nephrol Dial Transplant 2008;24(5):1539-44. [DOI:10.1093/ndt/gfn678] [PMID]
13. Dukas L, Schacht E, Runge M. Independent from muscle power and balance performance, a creatinine clearance below 65 ml/min is a significant and independent risk factor for falls and fall-related fractures in elderly men and women diagnosed with osteoporosis. Osteoporos Int 2010;21(7):1237-45. [DOI:10.1007/s00198-009-1064-1] [PMID]
14. Dukas L, Schacht E, Stähelin HB. In elderly men and women treated for osteoporosis a low creatinine clearance of< 65 ml/min is a risk factor for falls and fractures. Osteoporos Int2005;16(12):1683-90. [DOI:10.1007/s00198-005-1903-7] [PMID]
15. Schneider AL, Williams EK, Brancati FL, Blecker S, Coresh J, Selvin E. Diabetes and risk of fracture-related hospitalization: the Atherosclerosis Risk in Communities Study. Diabetes care 2013;36(5):1153-8. [DOI:10.2337/dc12-1168] [PMID] [PMCID]
16. Levraut J, Ichai C, Petit I, Ciebiera JP, Perus O, Grimaud D. Low exogenous lactate clearance as an early predictor of mortality in normolactatemic critically ill septic patients. Crit Care Med 2003;31(3):705-10. [DOI:10.1097/01.CCM.0000045561.85810.45] [PMID]
17. Jørgensen L, Jenssen T, Ahmed L, Bjørnerem Å, Joakimsen R, Jacobsen BK. Albuminuria and risk of nonvertebral fractures. Arch Intern Med 2007;167(13):1379-85. [DOI:10.1001/archinte.167.13.1379]

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.