Volume 31, Issue 4 (July 2020)
Studies in Medical Sciences 2020, 31(4): 282-294 |
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Associate Professor Department of Exercise Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran (Corresponding Author) , alibanaeifar@yahoo.com
Abstract: (3767 Views)
Background & Aims: PGC-1a is one of the most important regulators of cardiac mitochondrial biogenesis which plays a key role in lipid oxidation processes. The aim of this study was to investigate the effect of low-intensity endurance training and high-intensity interval training on the expression of PGC-1a and heart tissue triglyceride content in rats with fatty liver (NAFLD).
Materials & Methods: This experimental study was performed on 40 male Wistar rats. Rats were randomly divided into 4 groups. The control group received low-intensity endurance training and intense interval training that consumed high fat diet for 16 weeks and then the two training groups participated in the exercise program for 8 weeks. Also, the sham group used standard food during this time. Finally, expression levels of PGC-1a and intracellular adipose tissue of the four groups were measured.
Results: The results showed that expression of PGC-1a increased after endurance training and intense interval training in cardiac tissue of obese male rats. Also, both types of intense intermittent exercise and low-intensity endurance training significantly decreased the fat content of cardiac tissue (p<0/05).
Conclusion: The results showed that exercise training can increase the expression of PGC-1a and decrease the triglyceride content of the heart tissue in people with non-alcoholic fatty liver disease, indicating that exercise training can be a non-medicinal treatment for these people to use.
Materials & Methods: This experimental study was performed on 40 male Wistar rats. Rats were randomly divided into 4 groups. The control group received low-intensity endurance training and intense interval training that consumed high fat diet for 16 weeks and then the two training groups participated in the exercise program for 8 weeks. Also, the sham group used standard food during this time. Finally, expression levels of PGC-1a and intracellular adipose tissue of the four groups were measured.
Results: The results showed that expression of PGC-1a increased after endurance training and intense interval training in cardiac tissue of obese male rats. Also, both types of intense intermittent exercise and low-intensity endurance training significantly decreased the fat content of cardiac tissue (p<0/05).
Conclusion: The results showed that exercise training can increase the expression of PGC-1a and decrease the triglyceride content of the heart tissue in people with non-alcoholic fatty liver disease, indicating that exercise training can be a non-medicinal treatment for these people to use.
Keywords: Low-Intensity Endurance Training, High-Intensity Interval Training, PGC-1a, Heart Tissue, Triglyceride
Type of Study: Research |
Subject:
Exercise physiology
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