Volume 28, Issue 9 (Monthly_Dec 2017)
Studies in Medical Sciences 2017, 28(9): 572-581 |
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Faghfouri A H, Bagheri M, Mehdizadeh A, Ayremlou P, Teymour Azar M, Zarrin R. ASSOCIATION OF VITAMIN D STATUS AND BSMI POLYMORPHISM IN VITAMIN D RECEPTOR GENE WITH HASHIMOTO DISEASE IN URMIA. Studies in Medical Sciences 2017; 28 (9) :572-581
URL: http://umj.umsu.ac.ir/article-1-4019-en.html
URL: http://umj.umsu.ac.ir/article-1-4019-en.html
Amir Hossein Faghfouri 
, Morteza Bagheri , Alireza Mehdizadeh , Parvin Ayremlou , Mahsa Teymour Azar , Rasoul Zarrin *
, Morteza Bagheri , Alireza Mehdizadeh , Parvin Ayremlou , Mahsa Teymour Azar , Rasoul Zarrin *
Urmia University of Medical Sciences , rasoul.zarrin@uqconnect.edu.au
Abstract: (4919 Views)
Background & Aims: The hashimoto thyroiditis as a common autoimmune thyroid disease have a multifactorial etiology. Vitamin D status and vitamin D receptor gene BsmI polymorphism are involved in hashimoto developing. The aim of this research was to study the association between 25hydroxy vitamin D serum levels and BsmI polymorphism with hashimoto.
Materials & Methods: We conducted a case-control study of 105 adults with hashimoto thyroiditis and 105 matched healthy controls. BsmI polymorphism was investigated by PCR-RFLP. Moreover, after matching two groups for vitamin D intakes from diet and sun exposure habits, serum levels of 25-hydroxyvitamin D as vitamin D status were measured by electrochemiluminescence immunoassay. Data were analyzed with chi-square test, odds ratio, ANOVA, Mann-Whitney U test and independent t-test.
Results: Vitamin D deficiency (≤20ng/ml) was associated with higher susceptibility to hashimoto compared with vitamin D sufficiency (≥30ng/ml) (P = 0.02; adjusted OR = 2.74 CI 95%, 1.2-6.25). BsmI-"GG" genotype was higher in hashimoto group (P = 0.01). BsmI polymorphisms were not effective in vitamin D status (P> 0.05).
Conclusion: Our results revealed that vitamin D status and BsmI polymorphisms are involved in susceptibility to hashimoto disease. Further investigations of the relationship between VDR gene polymorphisms with hashimoto and vitamin D status are needed.
Materials & Methods: We conducted a case-control study of 105 adults with hashimoto thyroiditis and 105 matched healthy controls. BsmI polymorphism was investigated by PCR-RFLP. Moreover, after matching two groups for vitamin D intakes from diet and sun exposure habits, serum levels of 25-hydroxyvitamin D as vitamin D status were measured by electrochemiluminescence immunoassay. Data were analyzed with chi-square test, odds ratio, ANOVA, Mann-Whitney U test and independent t-test.
Results: Vitamin D deficiency (≤20ng/ml) was associated with higher susceptibility to hashimoto compared with vitamin D sufficiency (≥30ng/ml) (P = 0.02; adjusted OR = 2.74 CI 95%, 1.2-6.25). BsmI-"GG" genotype was higher in hashimoto group (P = 0.01). BsmI polymorphisms were not effective in vitamin D status (P> 0.05).
Conclusion: Our results revealed that vitamin D status and BsmI polymorphisms are involved in susceptibility to hashimoto disease. Further investigations of the relationship between VDR gene polymorphisms with hashimoto and vitamin D status are needed.
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