Background & Aims: Today, increasing resistance to antibiotics causes serious problems for treatment of patients. The aim of this study was to determine the role of AdeABC efflux pump in the Benzalkonium chloride and Chlorhexidine MIC value with efflux pump inhibitors (1-1-naphthylmethyl-piperazine and phenyl-arginine-β-naphthylamide) in the A.baumanii strains isolated from intensive care unit.

Materials & Methods: This study was conducted on 50 isolates of Acinetobacter baumannii collected from ICU wards of Gazi hospital. The species identification was performed by standard laboratory methods. Benzalkonium chloride and Chlorhexidine MIC value were performed using microdilution method according to the clinical and laboratory standards institute (CLSI) guidelines. The activity of the efflux pump was evaluated using the efflux pump inhibitors.

Conclusions: The AdeABC efflux pump may play a role in decreasing Benzalkonium chloride and Chlorhexidine MIC value   in A. baumannii isolates.

SOURCE: URMIA MED J 2016: 27(5): 401 ISSN: 1027-3727