Volume 26, Issue 9 (Monthly_Dec 2015)                   Studies in Medical Sciences 2015, 26(9): 802-812 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Samadi H, Javadi S, Asri S. EVALUATION OF THE EFFECTS OF CROCIN ON THE SERUM LEVELS OF GLUCOSE, INSULIN, UREA, CREATININE AND Β2M IN HEALTHY AND STREPTOZOTOCIN-INDUCED DIABETIC RATS. Studies in Medical Sciences 2015; 26 (9) :802-812
URL: http://umj.umsu.ac.ir/article-1-3140-en.html
Associate Professor, Department of Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran , S.Javadi@urmia.ac.ir
Abstract:   (7229 Views)

Received: 23 Aug , 2015 Accepted: 25 Oct , 2015

Abstract

Background & Aims: In order to evaluate the alleviative effect of crocin on diabetes mellitus and its kidney complications, the serum levels of glucose, insulin, urea, creatinine and &beta2M were examined in healthy and streptozotocin-induced diabetic rats after crocin administration.

Materials & Methods: In this study 45 rats were divided into 9 groups (5 each) of healthy control, diabetic control, diabetic treatment with crocin (two dose of 10 and 40 mg/kg) and diabetic positive treatment (with insulin 5 mg/kg) in a period of 20 days.

Results: The results indicated that the serum levels &beta2M, urea and creatinine significantly increased in diabetic rats. However, in groups receiving crocin with the dose of 10 and 40 mg/kg the serum levels of &beta2M were significantly lower than the control diabetic rats showing beneficial effect of crocin preventing diabetic nephropathy. Although the serum levels of urea and creatinine decreased in crocin receiving groups but they did not reach to a significant level.

Conclusion: Finally, crocin decreased the serum levels of &beta2M, glucose, urea and creatinine in diabetes mellitus causing a protective effect on the disease and its kidney complications. It seems the beneficial effect of crocin was modulating with stimulatory insulin secretion and ameliorative insulin resistance effects.

SOURCE: URMIA MED J 2015: 26(9): 812 ISSN: 1027-3727

Full-Text [PDF 738 kb]   (2968 Downloads)    
Type of Study: Research | Subject: General

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Studies in Medical Sciences

Designed & Developed by : Yektaweb