Background & Aims : Bone marrow stromal cells (BMSCs) are multipotent stem cells that can proliferate and differentiate into osteogenic cells . T his study aimed to investigate the effects of BMSCs transplantation for the repair of bone defects in rat.

  Materials & Methods : In this study twenty-eight male adult rats were equally divided into 4 groups. Group 1 ( control group) received no treatment after bone defect after bone defect the culture medium was injected at the site of bone defect for group 2 ( sham group) group 3 was non-autologous cell transplantation group and group 4 was autologous cell transplantation group. Bone histomorphometric evaluation s and cell counting were performed in all groups.

  Results : No significant differences were found between the control group and Sham according to histomorphometric study. The mean trabecular surface was significantly increased in autologous and non-autologous groups compared to the control group. In addition, mean number of osteocytes was increased in autologous and non-autologous groups when compared to the control group.

  Conclusion : It seems that both autologous and non-autologous BMSCs transplantation appears to be effective in the repair of bone defect.

  SOURCE: URMIA MED J 2014: 25(5): 424 ISSN: 1027-3727