Received: 3 Oct, 2012 Accepted: 15 Dec, 2012

  Department of Neurology, Emam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences

  Abstract

  Background & Aims: Multiple sclerosis is the most common demyelination inflammatory disease due to the greatest disability in young adults. Recent studies show that in addition to white matter involvement in the central nervous system in the pathogenesis of MS as well as a phenomenon Neurodegenerative early stages of disease, there are examples of it as a conflict cortex cells, brain atrophy is a gray. In recent studies peripheral demyelination neuropathy was observed in 5% of patients with MS. The purpose of this study was electro diagnostic peripheral nervous system evaluation in patients with multiple sclerosis.

  Materials & Methods: In a cross sectional and descriptive-analytical study conducted on patients with MS in the Department of Neurology University of Medical Sciences, changes in NCS in MS patients was examined.

  Results: 19 of the studied patients were male and 56 of them were female. MS disease in 20 patients (26.7%) patients was SP and in 55 (73.3%) patients were RR. The mean age of patients with type SP was 41.70 ± 11.93 and the mean age of patients with type RR, was 30.23 ± 9.51years (P<0.001). Mean involvement duration in patients with type SP was 8.85 ± 5 and the mean involvement duration in patients with type RR was 2.49 ± 2.83 years (P<0.001). Mean EDSS in patients with type SP was 6.05 ± 0.85 and the mean EDSS in patients with type RR was 2.92 ± 1.44(P<0.001). Most amplitude proneal motor disorder occurred in 22.66% and 11.33% in the sural amplitude disturbance. Maximum Latency occurred in tibial motor disorder in 16.66% of cases and the most disorder in the median and peroneal motor Velocity occurred at 9.33% of cases there was also the most impaired in F_Wave peroneal H_Reflex disorder occurred in 24.66% and 9.33%.

  Conclusions: In our study, median nerve motor amplitude of left tibial and peroneal motor was significant less than the normal mean, and Latency of right median nerve motor as well as significant less than mean normal society. Relationship between electro diagnostic findings in patients with age, disease duration and relapse number of disease and spinal cord involvement, the number of brain plaques, EDSS of patients studied did not exist. Mean velocity motor nerves studied no significant differences with middle mean. Mean Amplitude of median motor left mean Amplitude of tibial and peroneal motor was significant amount less than normal.

  SOURCE: URMIA MED J 2012: 23(7): 818 ISSN: 1027-3727