Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
22
5
2011
12
1
THE ASSESSMENT OF THE ULTRASTRUCTURAL OF LUMINAL EPITHELIUM IN THE HYPERSTIMULATED MICE UTEROUS AFTER APPLICATION OF ESTROGEN AND PROGESTERONE
393
398
FA
Fatemeh
Afshari
Department of Histopathology and Anatomy, School of Medicine, Islamic Azad University, Tabriz Branch, Tabriz, Iran
f_afshar@iaut.ac.ir
Y
Behrouz
Niknafs
Department of Anatomy, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
N
Abdolrahman
Dezfulian
Department of Histology, School of Medicine, Ahvaz University of Medical Sciences, Ahvaz, Iran
N
Background & Aims : Successful implantation of blastoctcyst requires a suitable environment of uterus. Ovarian hormones are responsible for induction of endometrial receptivity. The aim of this study was to determine the effects of different luteal support hormones on the ultrastructural changes in superovulated mice in the implantation window time. Materials & Methods : Adult male and female mice were used for induction of pesudopregnancy. The mice were divided into two groups: experimental and control groups. Female mice in the experimental group were superovulated and then were mated with vasectomised mice to induce psudopregnancy experimental group based on hormone injection were subdivided to five groups: sham group, estrogen, progesterone, estrogen + progesterone, and antiprogesterone + estrogen. The control group obtained without any hyperstimulation. The uterine of all groups were collected after 4.5 days of pregnancy and were prepared for the assessment of ultrastructural changes with TEM . Results : Our results showed that progesterone injection decreased the high of microvilli in the apical cell and increased the development of pinopods but estrogen increased the growth of microvilli while esterogen + progesterone injection increased the growth of pinopodes. Conclusion : The results obtained from this study showed that progesterone could not provide suitable condition of endometrium for implantation in comparison to the control group and adding estrogen to progesterone may improve endometrial condition to implant at luteal phase. Source: Urmia Med J 2011: 22(5): 494 ISSN: 1027-3727
Implantation, Superovulation, Estrogen, Progesterone
http://umj.umsu.ac.ir/article-1-1108-en.html
http://umj.umsu.ac.ir/article-1-1108-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
22
5
2011
12
1
399
409
FA
Alireza
Aghayousefi
Payame Noor University, Tehran, Iran
arayeh1100@gmail.com
Y
Mehdi
Dehestani
Payame Noor University, Tehran, Iran
N
Background & Aims: The aim of the current study was to investigate the effectiveness of coping-therapy on the well-being of mothers with disabled offspring. Materials & Methods : This quasi-experimental study included all volunteer mothers with disabled children referring to Saadatabad education center 21 mothers entered the intervention group, and 20 to the control group. The data were gathered through coping strategies questionnaire and personal wellbeing indicator before treatment sessions. They had an eight session coping therapy intervention and then completed post-tests. The data were analyzed statistically. Results : The results suggested that the mothers' wellbeing did not significantly improve in intervention group. Furthermore, the escape-avoidance strategy and confrontation coping mechanisms respectively decreased and increased. No other changes in coping mechanisms were found as a result of being under coping therapy intervention. In addition, positive correlations were found between social support seeking, self-control, responsibility, and wellbeing. Conclusion : It seems that coping therapy does not directly lead to wellbeing enhancement however, it affects the coping mechanisms of mothers and in long-term it will result in the wellbeing improvements. Source: Urmia Med J 2011: 22(5): 493 ISSN: 1027-3727
http://umj.umsu.ac.ir/article-1-1109-en.html
http://umj.umsu.ac.ir/article-1-1109-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
22
5
2011
12
1
THE EFFICACY OF HOME CARE EDUCATION ON KNOWLEDGE AND PERFORMANCE OF HEM DIALYSIS RENAL PATIENTS DISCHARGED FROM HOSPITALS
410
415
FA
Leila
Aliloo L
Islamic Azad University, Urmia Branch, Urmia, Iran
L_aliloo@yahoo.com
Y
Ali
Shakibi
Urmia University of Medical Sciences
N
Ali
Shargh
Urmia University of Medical Sciences
N
Background & Aims : This Research was aimed to determine the efficacy of home care education on knowledge and performance of hemodialysis renal patients discharged from hospitals of Urmia University of Medical Sciences, 2010. Materials & Methods: This experimental study included 70 hemodialysis renal patients discharged from hospitals. They subjects were divided to two groups as case and control by randomized method (each group contains 35 patients). The independent variable was home care education and the dependent variable was knowledge and performance of patients. The data were collected using a questionnaire that was prepared in three parts. The patients were interviewed to determine their knowledge and performance in two stages. In the first stage, some demographic information, and knowledge and performance of both groups were gathered, and then home care education was performed plus offering some booklets. The second stage for the study and control group started after 30 day of the last self care education section. In other to analyzing the data, SPSS were used. Both descriptive statistics and inferential statistics were applied. Results: The majority of the samples were female, married and were 25-44 years old. The average of acquiring knowledge was 26.9 before education which increased to 47.7 (P<0.05) for the study group. But in the control group was 30 in pretest and in posttest 30.1. The average of different performance was 44.4 before education which increased to 76.6 (P<0.05) for study group. But in the control group was 46.6 in pretest and in posttest was 45.5. There is a significant increase in both awareness and performance after the education. Conclusion: H ome care education of hemodialysis renal patients increases their knowledge and performance. Source: Urmia Med J 2011: 22(5): 492 ISSN: 1027-3727
Hemodialysis, Renal patients, Home care education, Knowledge, Performance
http://umj.umsu.ac.ir/article-1-1110-en.html
http://umj.umsu.ac.ir/article-1-1110-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
22
5
2011
12
1
A COMPARISON OF PREDICTIVE VALUE OF MODEL FOR END STAGE LIVER DISEASE AND CHILD-TURCOTTE-PUGH FOR VARICEAL BLEEDING
416
421
FA
Ramin
Behroozian
Urmia University Of Medical Sciences
Rbehroozian@gmail. com
Y
Peivand
Mohammadi
Urmia University of Medical Sciences
N
Kamran
Shateri
Urmia University of Medical Sciences
N
Reza
Purali
, Urmia University of Medical Sciences
N
Background & Aims : Risk factors for r ebleeding following acute variceal haemorrhage are incompletely understood. The aim of this study was to determine the predictor validity of model for end stage liver disease (MELD) score and Child-Turcotte-Pugh (CTP) in acute variceal bleeding and rebleeding. Method : The study included 92 cirrhotic patients of Imam Khomeini hospital. The predictive capability of CTP and MELD score were compared. Results : The mean MELD score in 39 patients with variceal bleeding was 18.7±7.2, and in 59 patients without bleeding was 14.9±9.8 (P=0.014). The mean CTP score in 39 patients with variceal bleeding was 9.05±1.6, and in 59 patients without bleeding was 8.5± 1.5 (p>0.05). Conclusion : MELD was significantly better than CTP score for predicting in hospital bleeding. MELD and CTP were not efficacious scores for predicting variceal rebleeding. Source: Urmia Med J 2011: 22(5): 491 ISSN: 1027-3727
Variceal bleeding, Model for end stage liver disease score, Child-Turcotte-Pugh (CTP)
http://umj.umsu.ac.ir/article-1-1111-en.html
http://umj.umsu.ac.ir/article-1-1111-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
22
5
2011
12
1
THE EFFECT OF LEVOTHYROXINE REPLACEMENT THERAPY ON BONE MINERAL DENSITY IN PREMENOPAUSAL WOMEN WITH HYPOTHYROIDISM
422
426
FA
Shokoufeh
Bonakdaran
Endocrine Research Center, Ghaem Hospital, Mashhad, Iran
dr.bonakdaran@yahoo.com
Y
Nayereh
Saadati
Rheumatology Ward, Ghaem Hospital, Mashhad, Iran
N
Background & Aims : Many reports show a relation between exogenous thyroxine therapies on bone mineral density but the net effects remain unclear. The aim of this study was to determine the effect of replacement dose of levothyroxine on bone mineral density in premenopausal women with primary hypothyroidism . Materials & Methods: This study included 50 women with primary hypothyroidism. Patients with history of thyroid surgery and iodine ablation, patients with other diseases, or drugs that interfered with bone mineral density were excluded from this study. Bone mineral density was measured before and after 24 months of replacement dose of levothyroxine treatment. Statistical analysis was done by paired t-test. The data before and after levothyroxine therapy were compared with each other . Results : The mean age of patients was 34.4 ±5.3 years. The mean lumbar bone mineral percent before treatment was %78.8±15.2 and mean T score in lumbar area was -1.4±0.86. After two years of treatment, the mean lumbar bone mineral percent and lumbar T score changed to %78.4±13.6 and -1.7±0.57, respectively. The mean bone mineral percent in neck of femur was %88.47±13.04 and T score was -1.05±1.07 before treatment that changed to %92.0±8.07 and T score -0.9±0.88 after levothyroxine treatment. These changes were not significant . Conclusion : Replacement dose of Levothyroxine therapy for at least two years in pre-menopausal women with hypothyroidism does not cause any significant change in bone mineral density . Source: Urmia Med J 2011: 22(5): 490 ISSN: 1027-3727
Levothyroxine, Hypothyroidism, Bone mineral density, Osteoporosis
http://umj.umsu.ac.ir/article-1-1112-en.html
http://umj.umsu.ac.ir/article-1-1112-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
22
5
2011
12
1
EFFECT OF WAIST CIRCUMFERENCE AND BODY MASS INDEX IN RESULTS OF EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY IN STONE SMALLER THAN 2 CM
427
431
FA
Afshar
Zomorrodi
Imam Reza Hospital, , Tabriz University of Medical Sciences, Tabriz, Iran
N
Behzad
Khanmohammadi
Imam Reza Hospital, , Tabriz University of Medical Sciences, Tabriz, Iran
N
Ali
علی تبریزی
Student`s Research Committee , Tabriz University of Medical sciences, Tabriz, Iran
ali.tab.ms@gmail.com
Y
Elham
Eslami
Imam Reza Hospital, , Tabriz University of Medical Sciences, Tabriz, Iran
N
Background & Aims: Studies show that body mass index (BMI) can predict success rate of extracorporeal shock wave lithotripsy (ESWL). In this study, we aimed to evaluate the relation between BMI and waist circumference with success rate of ESWL and stone free rate after ESWL. Materials & Methods : In a descriptive cross-sectional study, 64 patients with kidney stone size 0.5 to 2 cm for urinary tract lithotripsy were studied. In all patients waist circumference, weight and height were measured at first refer. Stone analysis was done after lithotripsy. Also, in order to determine residual stones in week 6 after ESWL, kidney radiographs were taken. Results : In 64 patients including 43(67.2%) men and 21(32.8%)women, the average stone size was 12.90±3.99 mm. The patients' mean BMI was 25.91±4.34 kg/m2 and waist circumference was 89.82±14.43 cm. Thirty tree patients (51.6%) were stone free and 31 (48.4%) had residual stone. There was no significant difference between stone free rate and sex, stone location and mean BMI. There was no significant difference in waist circumference between groups. Conclusion : Results of this study showed that body mass index and waist circumference have no role in predicting response to ESWL treatment and stone free rate after ESWL. Source: Urmia Med J 2011: 22(5): 489 ISSN: 1027-3727
Extracorporeal shock wave lithotripsy, Body mass index, kidney Stone, waist circumference
http://umj.umsu.ac.ir/article-1-1113-en.html
http://umj.umsu.ac.ir/article-1-1113-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
22
5
2011
12
1
A COMPARATIVE STUDY OF PERSONALITY FACTORS AND MENTAL HEALTH COMPONENTS IN HEART PATIENTS AND NORMAL ONES
432
438
FA
Shirin
Zeinali
Shahid Beheshti University, Tehran, Iran
N
Parvaneh
Ashrafian
Tabriz University, Tabriz, Iran
p.ashrafian87@yahoo.com
Y
Mansuor
Beirami
Tabriz University, Tabriz, Iran
N
Background & Aims: This study compares the personality profile and psychological factors of heart patients with normal people. The aim was identifying personality traits and psychological factors that relate to people who suffer from heart diseases, and help them to cope with problems and adjust with life. Method ;Material: The method of this study was post hoc. For this purpose 105 people selected from Shahid Madani center and filled (NEO) personality inventory and psychological factor scale (DASS). Then 94 people were selected as matched group. Results: The result showed neuroticism was high in heart patients (p<0.05). Also there were significant differences in openness in normal people (p<0.001). Depression and stress was high in heart patients (p<0.05). And anxiety was high in these patients too (p<0.001). Conclusion: In general the result of this research demonstrated that the factors of neuroticism, c onscientious, depression, anxiety, and stress are high. However, openness is low in heart patients. Hence, the study shows that people who suffer from heart diseases need psychotherapy. Source: Urmia Med J 2011: 22(5): 488 ISSN: 1027-3727
C oronary heart disease (CHD), Personality factors, Mental health
http://umj.umsu.ac.ir/article-1-1114-en.html
http://umj.umsu.ac.ir/article-1-1114-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
22
5
2011
12
1
439
448
FA
Salar
Faramarzi
University of Isfahan, Isfahan, Iran
s.faramarzi@edu.ui.ac.ir
Y
Amir
Ghamarani
University of Isfahan, Isfahan, Iran
N
Maryam
Shariati
psychology faculty of shahid chamran
N
Background & Aims: The purpose of this study was to survey and compare the prevalence and frequency of behavioral disorders among high school students considering gender, field of study, and place of residence in Bostanabad. Materials & Methods: This descriptive cross sectional study was conducted through the stratified sampling proportion and included 384 students. Data were gathered with Achenbach's Behavioral Problems (YSR) scale and analyzed by descriptive and inferential statistics . Results : Among high school students, aggressive behavior had the highest and somatisization disorder the lowest prevalence. Also the prevalence of withdrawal / depression and other problems (including school phobia, nail biting, etc.) were significantly higher in girls (p ≤ 0.05), and law-breaking behavior was significantly higher in boys (p ≤ 0.05). While in urban students the prevalence of withdrawal / depression and aggressive behavior, was significantly more than rural students (p≤0.05). There was no significant difference between students according the field of study . Conclusion: The results can be obtained in order to clarify mental health disorders and the need for further planning. Source: Urmia Med J 2011: 22(5): 487 ISSN: 1027-3727
Behavioral disorder, Prevalence, Secondary school students
http://umj.umsu.ac.ir/article-1-1116-en.html
http://umj.umsu.ac.ir/article-1-1116-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
22
5
2011
12
1
449
458
FA
Elham
Mohammadzadeh
School of Medicine, Mashhad University of Medical Sciences
N
Alireza
Ebrahimzadeh Bideskan
School of Medicine, Mashhad University of Medical Sciences
Ebrahimzadehba@mums.ac.ir
Y
Mohamad reza
Nikravesh
School of Medicine, Mashhad University of Medical Sciences
N
Mehdi
Jalali
School of Medicine, Mashhad University of Medical Sciences
N
Fatemeh
Nikmard
School of Medicine, Mashhad University of Medical Sciences
N
Alireza
Fazel
School of Medicine, Mashhad University of Medical Sciences
N
Background & Aims : Hair follicle morphogenesis is controlled by complex reprocical ectodermal–mesenchymal interactions regulated by molecular mechanisms. In addition, glycoconjugates are known to be important for molecular interactions during developmental processes. The aim of this research was to study glcoconjugate terminal sugars distributions and changes during rat hair follicle morphogenesis using light microscopic lectinhistochemical technique. Materials & Methods : Using lectinhistochemistry technique formalin-fixed paraffin-embedded 16, 18, and 20 day-rats and were incubated with different HRP-lectins from Lotus tetragonolobus (LTA), Arachis hypogaea or Peanut (PNA) and Glycine max (soybean) agglutinin (SBA) that are specific for α-L Fuc, Gal (β1→3) GalNAC and D-Gal (β1→3) DGalNAC terminal sugars, respectively. On the basis of colorimetery data that was determined by blind method, the sections were graded and photographed. Results : T he epithermal bud, basement membrane, and mesenchimal condensation reacted with PNA on E16. Some component of developing hair follicle such as epithermal root sheath and cortex reacted with PNA moderately on E18 and these reactions followed on E20 to various degrees: weak and intensive, respectively. The reactions of Epithermal bud and mesenchimal condensation with SBA were weak and moderate, respectively on E16. Basement membrane, cortex, and epithermal root sheath reacted with SBA weakly on E18. Cortex, cuticle and epithermal root sheath reacted strongly on E20. The epithermal bud and mesenchimal condensation reacted with LTA on E16 moderately. Basement membrane, cortex and epithermal root sheath reacted with LTA weakly and matrix reacted strongly on E18. Basement membrane, cortex, cuticle and epithermal root sheath reacted strongly and matrix reacted moderately on E20. Conclusion : Finally, glcoconjugate terminal sugars expression such as α-L Fuc, Gal (β1→3) GalNAC and D-Gal (β1→3) DGalNAC are developmentally regulated during hair follicle morphogenesis. Source: Urmia Med J 2011: 22(5): 486 ISSN: 1027-3727
Hair follicle development, Glycoconjugates, PNA Lectin, LTA lectin, SBA lectin
http://umj.umsu.ac.ir/article-1-1121-en.html
http://umj.umsu.ac.ir/article-1-1121-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
22
5
2011
12
1
A SURVEY ON SCHIZOTYPAL PERSONALITY FEATURES IN SHIRAZ UNIVERSITY STUDENTS USING STA SCALE
459
466
FA
Ali
Mohammadzadeh
Psychology Department, Payam Nour University of East Azerbaijan, Tabriz, Iran
ali.mohammadzadeh@gmail.com
Y
Masuod
Ghorbanalipour
Islamic Azad University, Khoy Branch, Khoy, Iran
N
Rohiyeh
Neisari
Urmia University of Medical Sciences
N
Background & Aims : Dimensional approach assumes the psychosis symptoms to be exaggerated manifestation of personality traits that have a continuous distribution in a population. It represents schizotypy as continuously distributed traits. The aim of the present study was to assess the psychotic like symptoms schizotypal personality disorder focusing on age and gender differences. Materials ;Methods : This descriptive-cross sectional study was conducted on 749 normal students of Shiraz University. The participants answered to schizotypal personality scale (STA). Results : Distribution rates of the schizotypal personality features and its components were reported with regard on age and gender differences. Females were characterized by higher scores on whole STA and paranoid suspiciousness/social anxiety and magical thinking factors. The results of this study also showed the effect of age is neglectable in university age samples. Conclusions : The findings of this research provide more research-based confirmations for dimensional model of psychosis . Source: Urmia Med J 2011: 22(5): 485 ISSN: 1027-3727
Schizotypal personality, Psychosis, STA scale, Survey schizotypal personality features
http://umj.umsu.ac.ir/article-1-1117-en.html
http://umj.umsu.ac.ir/article-1-1117-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
22
5
2011
12
1
THE EFFECT OF AVENA SATIVA ALCOHOLIC AND AQUEOUS EXTRACT ON THE WOUND HEALING AND SKIN INFLAMMATION
467
473
FA
Hossein
Nazari
Biochemistry Department, Faculty of Medicine, Semnan University of Medical Sciences, Semnan Educational Center of Jahad Keshavarzi, Semnan, Iran
hossen253@yahoo.co.uk
Y
nasrin
Jahanjo
Semnan Educational Center of Jahad Keshavarzi, Semnan
N
Mehdi
Safarieh
Semnan Educational Center of Jahad Keshavarzi, Semnan
N
Mehdi
Taherian
Semnan University of Medical Sciences, Food Science and Drug Laboratory, Semnan
N
Ali
Khaleghian
Biochemistry Department, Faculty of Medicine, Semnan University of Medical Sciences
N
Abbasali
Vafaei
Faculty of Medicine, Semnan University of Medical Sciences
N
Ahmadreza
Bandegi
Biochemistry Department, Faculty of Medicine, Semnan University of Medical Sciences
N
Hadi
Amrollahi
Microbiology Department, Faculty of Medicine, Semnan University of Medical Sciences
N
Abuolfazl
Mohamadi
, Biochemistry Department, Faculty of Medicine, Semnan University of Medical Science
N
Background & Aims : Man in all historical periods had to use domestic and medicine herbal plants. Over the last half century, the use of synthetic and chemical drugs is highly prevalent. The harmful effect of chemical drugs on human life has increased the tendency to use medicinal plants once more. The aim of this study was to investigate the effect of Avena sativa active ingredients on the wound healing and skin inflammation on the rat model. Materials & Methods : Extract of water, methanol and ethanol Avena sativa seeds were prepared by water distillation and Soxhlet systems. The components of all samples were determinate using TLC experiment. Thirty male Wistar rats in five groups were used in this experimental study and the rats were anesthetized with Ketamin (1 mg/kg), and standard ulcer (2 cm) was induced on the shaved dorsal by scatter. Result : The results of this experiment showed that all extracts decreased the time of wound healing significantly in comparison with the controls groups. There was no symptom of colloid even scar Conclusion : These extracts seem to accelerate the formation of the epidermis and causes wound healing. Total extract of Avena sativa has an important role in wound healing. Source: Urmia Med J 2011: 22(5): 484 ISSN: 1027-3727
Avena sativa extract, Ulcer, Skin inflammation, Rat
http://umj.umsu.ac.ir/article-1-1118-en.html
http://umj.umsu.ac.ir/article-1-1118-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
22
5
2011
12
1
ENDOTHELIAL FUNCTION BIOMARKERS AND LIPID PROFILE IN WOMEN AND MEN WITH METABOLIC SYNDROME
474
479
FA
Fariba
Valipoor
, Faculty of Science, Science and Research Branch, Islamic Azad University
N
Mohamad hassan
Khadem Ansari
Faculty of Medicine, Urmia University of Medical Sciences
N
Neda
Valizadeh
Faculty of Medicine, Urmia University of Medical Sciences
N
Yuosef
Rasmi
, Faculty of Medicine, Urmia University of Medical Sciences,
mhansari1@umsu.ac.ir
Y
Background & Aims : The metabolic syndrome (MS) is a clustering of risk factors of metabolic origin that increases the risk for cardiovascular disease . Endothelial function biomarkers and lipids profile determine cardiovascular disease . Aim of this study was to investigate the effect of sex on endothelial function and lipid profile. Materials & M ethods: The present study involved 77 patients (59 women, 18 men) with metabolic syndrome that were defined according to Adult Treatment Panel III (three altered factors from five factors including abdominal obesity, elevated TG, low HDL-c, increased blood pressure, Fasting blood sugar (FBS) intolerance). Tests were detected by ELISA and biochemistry methods. Results : Body mass index (women 34.56±4.97 kg/m2 men 30.22 ± 3.01 kg/m2) waist circumference (women 110.18±10.52 cm 105.06±5.65 cm) were higher in women with metabolic syndrome (p 0.05). Endotelin-1 was significantly higher in women with MS (p< 0.05). Intercellular adhesion molecule (ICAM-1), E-selectin, NO2-, NO3- levels were similar in women and men with MS (p> 0.05). There were positive correlations between endothelial biomarkers in women with MS. Conclusion : Visceral obesity in women may be the major cause of metabolic syndrome. Abdominal obesity may contribute to MS through its action as an endocrine organ that produces proinflammatory cytokines . Source: Urmia Med J 2011: 22(5): 483 ISSN: 1027-3727
Metabolic syndrome, Endothelial function , W omen, Men , Lipid profile
http://umj.umsu.ac.ir/article-1-1119-en.html
http://umj.umsu.ac.ir/article-1-1119-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
22
5
2011
12
1
COMPLETE REMISSION OF SYNOVIAL SARCOMA FOLLOWING NEOADJUVANT CHEMORADIATION
480
481
FA
Mohamad
Mozafar
Shahid Beheshti University of Medical Sciences
N
Hamid
Mirzaei
Shahid Beheshti University of Medical Sciences
N
Hojjat
Molaei Govarchin Ghale
Emam Khomeyni Hospital, Chaypare, Iran
hojjat_9@hotmail.com
Y
Mohamad Ali
Shahabedin
Shahid Beheshti University of Medical Sciences, Tehran
N
Synovial sarcoma (SS) is a rare but distinctive soft tissue sarcoma (STS) that displays epithelial differentiation. It consists of 5% to 10% of STSs. Surgery is the mainstay of treatment to prevent local recurrence and maximam five-year survival rate is 40 %. Recently, SS was noted to have increased post chemotherapy survival time and the sensitivity of SS to ifosfamide-based chemotherapy has been documented with encouraging results from high-dose ifosfamide therapy.
The reported case is a 31 year old man admitted with right shoulder pain and mass from 6 months ago. Primary incisional biopsy reported poorly differentiated synovial sarcoma without any sign of lymphadenopathy or distant metastasis. Due to neurovascular proximity patient referred to an oncologist and received 6 courses Adriamycin, ifo-fosfamide and mesna for 3 weeks. Then he was operated with safe margins and defects covered with thoracoabdominal rotational flap. New pathology report showed necrotic tissues but malignant cells. Then he was treated with post operative radiotherapy and chemotherapy. Amble focused on early diagnosis and the performance of wide surgical removal. Scialabba confirmed survival is associated with small lesions, absence of metastases, and histologically low-grade lesions. Méndez concluded that wide complete surgical resection is mandatory and radiotherapy will only be necessary for uncertain margins, and chemotherapy has not clear benefits as adjuvant therapy in some lesions but its employing is recommended in all cases because of the poor prognosis due to local recurrence.
According to available data neoadjuvant chemotherapy can help surgeon in inoperable cases and our patient got neoadjuvant chemotherapy and then underwent the surgery. The report of pathology was amazing because no malignant cell was found in specimen and now we present this case as a curable case of sarcoma.
Source: Urmia Med J 2011: 22(5): 482 ISSN: 1027-3727
http://umj.umsu.ac.ir/article-1-1120-en.html
http://umj.umsu.ac.ir/article-1-1120-en.pdf