Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
28
9
2017
12
1
THE EFFECT OF COMBINED ATORVASTATIN AND ZINC SULFATE ON SERUM LEVELS OF GLUCOSE AND LIPIDS IN TYPE I DIABETIC RATS
507
519
FA
zahra
karampour gibchag
Department of Biology, Faculty of Science, Urmia University
zkarampoor@yahoo.com
Y
reza
heidari
Department of Biology, Faculty of Science, Urmia University
r.heidari@mail.urmia.ac.ir
N
meysam
abtahi
Department of Microbiology, Faculty of Veterinary Medicine, Urmia
meysamabtahi@hotmail.com
N
Background & Aims: Diabetes is the most common endocrine disease associated with impaired glucose and lipid metabolism. The aim of this study was to evaluate the effects of combined atorvastatin and zinc sulfate on blood glucose and lipids in diabetic rats.
Materials & Methods: One control group (group NC) and four diabetic groups as diabetic control (group DC), treatment with atorvastatin 20mg/kg (group DA), treatment with zinc sulfate 30mg/kg (group DZ) and treatment with combination in half doses of both (group DZA)]. One month after treatment (orally), animals were euthanized and serum levels of glucose and lipids were evaluated. At the end, the data were analyzed by SPSS software, ANOVA and Tukey tests.
Results: The results of this study showed that treatment of diabetic rats with atorvastatin alone rather than decreasing blood sugar, caused a significant decrease (p<0/05) in lipid, and treatment of diabetic rats with zinc sulfate and combination in half doses of atorvastatin and zinc sulfate in addition to significant reduction in glucose serum levels, caused significantly decrease in total cholesterol, triglyceride, LDL and significant increase in HDL levels compared to the diabetic group.
Conclusion: It seems that combination of atorvastatin and zinc oxide have synergistic benefits in controlling blood sugar levels and lipid profile and thus in controlling diabetes.
Diabetes, Atorvastatin, Zinc sulfate, Glucose, Lipid profile
http://umj.umsu.ac.ir/article-1-4075-en.html
http://umj.umsu.ac.ir/article-1-4075-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
28
9
2017
12
1
prevalence of second mesiobuccal canal in maxillary canal in maxillary first molar by cone beam computed tomography in patients referred to radiology centers of urmia in 2011-2014
520
528
FA
aisan
ghaznavi
Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Urmia University of Medical Sciences
aisanghaznavi@yahoo.com
N
Amir
illbegi Diarjan
Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Urmia University of Medical Sciences
amirilbegi@gmail.com
N
akbar
abaszadeh
Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Urmia University of Medical Sciences
dr.a.abbaszadeh@gmail.com
N
mohammad
jafary heidarloo
Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Urmia University of Medical Sciences
m.jafaridr@yahoo.com
N
maziar
esmaili moghoddam
Department of Orthodontics, Faculty of Dentistry, Urmia University of Medical Sciences,
maziaremoghaddam@yahoo.com
Y
Background & Aims: The aim of this in vivo study was to determine the prevalence of the second mesiobuccal canal in the maxillary first molars of patients wh6 referred to the radiology clinics in Urmia using cone beam computed tomography.
Materials & Methods: In this descriptive cross-sectional study, 167 CBCT images of the maxillary first molars (kVp=90, MA=12 and a voxel size = 0.2 mm FOV=9*13cm), which included maxillary anatomy, were evaluated by two expert observers (two radiologists). The images were evaluated at the axial plane reconstruction with 1 mm slice thickness and 1 mm interval from the pulp chamber floor of the tooth to 4-5 mm apical to the CEJ.
Results: In the sample population, the prevalence of the maxillary first molar second mesiobuccal canal was estimated to be 9.88 %, 8.08% and 23.66% on the left, right, and both sides, respectively. Based on the independent t-test results, there was no significant association between the gender of the individuals or side of the teeth and prevalence of MB2.
Conclusion: Despite the limitations of the current study, it could be concluded that, roughly, 41 percent of the maxillary first molars have an MB2 canal. We found no significant correlation between the gender of the individuals or the side of the teeth and occurrence of MB2. In general, the mesiobuccal root of the maxillary first molars has more variations in canal anatomy in comparison to the distobuccal and buccal roots. Relatively high prevalence of MB2 canal increases the probability of endodontic failures. Therefore, using the noninvasive CBCT imaging may contribute significantly to the treatment of maxillary molars due to its high precision.
root canal obturation, root canal preparation,molar, maxilla, cone beam computed tomogarphy, morphology
http://umj.umsu.ac.ir/article-1-3985-en.html
http://umj.umsu.ac.ir/article-1-3985-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
28
9
2017
12
1
Assessing quality of life and its relationship with emotional intelligence amongst the Multiple Sclerosis patients referred Urmia Association of Multiple Sclerosis.
529
539
FA
syyedhadi
Azami
Department of Psychology, Urmia Branch, Islamic Azad University, Urmia, Iran
m.hadi1354 @gmail.com
N
Siamak
sheykhy
Associated Professor, Department of Psychology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author)
Y
Background & Aims: Multiple sclerosis (M.S.) disease is one of the most common neurological disorders in the world. Considering the fact that quality of life as subjective mental feeling can be related to psychological variables such as emotional intelligence, the present study aimed to investigate the quality of life and its relation to emotional intelligence in patients with M.S in Urmia city.
Materials & Methods: This study was conducted on 214 patients (92 males and 122 females) who were selected by available sampling method. To collect data WHOQOL-BREF quality of life assessment and emotional intelligence questionnaire were used. The data were analyzed using multivariate regression and correlation coefficient.
Results: It was revealed that there was significant relationship between the quality of life and emotional intelligence components such as happiness, self-fulfillment, independence, realism; and reverse relationship with elements of problem solving, interpersonal relationships and empathy.
Conclusion: The present results suggest that there is relationship between quality of life and significant components of emotional intelligence.
Multiple sclerosis (M. S), quality of life, Emotional Intelligence.
http://umj.umsu.ac.ir/article-1-3764-en.html
http://umj.umsu.ac.ir/article-1-3764-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
28
9
2017
12
1
The effectiveness of group therapy based on commitment and acceptance of the increase in life satisfaction in people with empty nest syndrome
540
547
FA
Mohammad
Tahan
Young Researchers and Elite Club, Birjand Branch, Islamic Azad University, Birjand, Iran
t.mohammad2@gmail.com
Y
Zahra
Askari
Torbat Jam Branch, Islamic Azad University, Torbat Jam, Iran
t.mohammad2@gmail.com
N
Elahe
Ahangri
Payam Noor University of Kashmar, Kashmar, Iran
t.mohammad2@gmail.com
N
Background & Aims: The aim of this study was to evaluate the efficacy of group-based therapy on commitment and acceptance in increasing life satisfaction in patients with empty nest syndrome.
Materials & Methods: The semi-experimental research had pretest design with control group. The statistical population included all middle aged people who referred to Kashmar Psychiatric Center in 2016. And 30 volunteers were selected randomly and were divided into two groups of 15 experimental and control groups. The experimental group received 8 consecutive 90-minute treatment sessions based on admission and commitment, and the control group did not receive any treatment. Both groups responded to the life-satisfaction questionnaire (SWLS) at the beginning and the end of treatment. Statistical analysis of the data was done with SPSS-22 and inferential statistics (covariance analysis).
Results: Findings showed that the mean of life satisfaction scores in the post test of the experimental group was significantly higher than the mean post-test scores in the control group.
Conclusion: The results showed that a group based on commitment and acceptance therapy leads to an increase in life satisfaction in people with empty nest syndrome. It can therefore be considered as a therapeutic approach.
Acceptance and commitment, life satisfaction, empty nest syndrome
http://umj.umsu.ac.ir/article-1-3824-en.html
http://umj.umsu.ac.ir/article-1-3824-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
28
9
2017
12
1
Healing effects of ion-exchanged zeolite nanocomposite on third -degree burn wound in mice
548
559
FA
Sara
Javanmardi
University of Tabriz
Y
Masoumeh
Moradi Arzlou
University of Tabriz
N
Seyed Hosein
Jarolmasjed
University of Tabriz
N
Background & Aims: Zeolite has skin wound healing capacity. However, its efficacy on burn wound healing has not yet been examined. In this study, we investigated the effects of Zeolite-Ag+/Gelatin nanocomposite on the process of third-degree burn wound healing in mice model.
Materials & Methods: Ag+- zeolite/gelatin nanocomposite was fabricated by sol-gel method; MTT assay and antimicrobial activity evaluation of the nanocomposite were performed. Third degree burn wound were created on 40 Balb/c mice (n=10) wound per group and treatment administered daily starting on the day of wounding. Treatment groups included untreated control, SSD, gelatin and nanocomposite. Daily photographs were taken and change in wound area relative to initial area was calculated. At 7 and 14 days, animals euthanized and skin samples were taken to histopathologicl evaluation (H&E staining). Then, the study groups were evaluated for wound contraction percent and histopathological parameters.
Results: According to the results of the present study, nano composite-treated wounds revealed significant wound contraction on days 14 compared to control and gelatin treated groups (P<0.0001). Considering investigated histopathological parameters including re-epithelialization angiogenesis and fibroplasia in mice treated with nanocomposite the rate healing of was significantly accelerated when compared to the other groups.
Conclusion: In conclusion, based on the results of the present study, it could be concluded that zeolite-Ag/gelatin nanocomposite offered potential advantages in burn wound healing acceleration and improvement. However, clinical use of this nanocomposite needs more supportive studies.
healing, third burn wound, of zeolite-Ag/gelatin nanocomposite, mice
http://umj.umsu.ac.ir/article-1-4049-en.html
http://umj.umsu.ac.ir/article-1-4049-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
28
9
2017
12
1
PROTECTIVE EFFECT OF NANO ZINC OXIDE ON TESTIS AND SEX HORMONE LEVELS OF MICE AFTER TREATMENT WITH PHENYLHYDRAZINE
560
571
FA
Ali
Soleimanzadeh
Urmia University
a.soleimanzadeh@urmia.ac.ir
Y
Abbas
Ahmadi
Urmia University
abbas.ahmadi@urmia.ac.ir
N
Background & Aims: Phenylhydrazine cause adverse effect on testis tissue and hormone levels. This study was conducted to evaluate the effects of nano zinc oxide on the Testis Tissue and sex hormone levels after Phenylhydrazine-induced hypoxia in male mice.
Materials & Methods: In order to perform the study 72 adult male mice with the capability of fertilizing with the age range of 6-8weeks randomly divide to 9 groups. Group 1 (control); Group 2 (Phenylhydrazine 8 mg/100 gr/b.w/ i.p. first time and 6 mg/100 gr/b.w/ i.p. every 48 hour); Group 3 (Sham 0.1 ml/kg/ i.p.), Group 4 (Phenylhydrazine + nano zinc oxide 1 mg/kg/i.p.); Group 5 (Phenylhydrazine + nano zinc oxide 2.5 mg/kg/i.p.); Group 6 (Phenylhydrazine + nano zinc oxide 5 mg/kg/i.p.); Group 7 (nano zinc oxide 1 mg/kg/i.p.); Group 8 (nano zinc oxide 2.5 mg/kg/i.p.) and Group 9 (nano zinc oxide 5 mg/kg/i.p.). 35 days after the last treatment, they were euthanized and following analyzing the sperm features, morphologic and mophometric changes, serum level of testosterone and LH and FSH levels were also evaluated. Data were analyzed using SPSS and a value of p < 0.05 was considered as statistically significant.
Results: The groups receiving only Phenylhydrazine showed a considerable reduction in testicles weight, spermatogenesis indicies, Tubular Differentiation Index, Spermatogenic Index and, most of the semniferous tube laked spermatozoa and the height epithelial and number of sertoli cell and leydig cell and diameter of semniferous tube had decreased, and the interstitial tissue increased and edmatos. However treatment with nano zinc oxide caused considerable improvement in mentioned parameters.
Conclusion: The results of this study showed that nano zinc oxide in lower dose (2.5 mg/kg) can have protective role against adverse effect caused by phenylhyrazine.
Phenylhydrazine, hypoxia, nano zinc oxide, testis, mice
http://umj.umsu.ac.ir/article-1-4012-en.html
http://umj.umsu.ac.ir/article-1-4012-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
28
9
2017
12
1
ASSOCIATION OF VITAMIN D STATUS AND BSMI POLYMORPHISM IN VITAMIN D RECEPTOR GENE WITH HASHIMOTO DISEASE IN URMIA
572
581
FA
Amir Hossein
Faghfouri
Urmia University of Medical Sciences
amir.nut89@gmail.com
N
Morteza
Bagheri
Urmia University of Medical Sciences
mortazabagheri@yahoo.com
N
Alireza
Mehdizadeh
Urmia University of Medical Sciences
Alireza_mehdizadeh@yahoo.com
N
Parvin
Ayremlou
Urmia University of Medical Sciences
p.ayremlou@gmail.com
N
Mahsa
Teymour Azar
Urmia University of Medical Sciences
mahsa.teymouriazar@gmail.com
N
Rasoul
Zarrin
Urmia University of Medical Sciences
rasoul.zarrin@uqconnect.edu.au
Y
Background & Aims: The hashimoto thyroiditis as a common autoimmune thyroid disease have a multifactorial etiology. Vitamin D status and vitamin D receptor gene BsmI polymorphism are involved in hashimoto developing. The aim of this research was to study the association between 25hydroxy vitamin D serum levels and BsmI polymorphism with hashimoto.
Materials & Methods: We conducted a case-control study of 105 adults with hashimoto thyroiditis and 105 matched healthy controls. BsmI polymorphism was investigated by PCR-RFLP. Moreover, after matching two groups for vitamin D intakes from diet and sun exposure habits, serum levels of 25-hydroxyvitamin D as vitamin D status were measured by electrochemiluminescence immunoassay. Data were analyzed with chi-square test, odds ratio, ANOVA, Mann-Whitney U test and independent t-test.
Results: Vitamin D deficiency (≤20ng/ml) was associated with higher susceptibility to hashimoto compared with vitamin D sufficiency (≥30ng/ml) (P = 0.02; adjusted OR = 2.74 CI 95%, 1.2-6.25). BsmI-"GG" genotype was higher in hashimoto group (P = 0.01). BsmI polymorphisms were not effective in vitamin D status (P> 0.05).
Conclusion: Our results revealed that vitamin D status and BsmI polymorphisms are involved in susceptibility to hashimoto disease. Further investigations of the relationship between VDR gene polymorphisms with hashimoto and vitamin D status are needed.
Vitamin D receptor, gene polymorphism, BsmI, vitamin D, Hashimoto
http://umj.umsu.ac.ir/article-1-4019-en.html
http://umj.umsu.ac.ir/article-1-4019-en.pdf
Urmia University of Medical Sciences
Studies in Medical Sciences
2717-008X
2717-008X
28
9
2017
12
1
Comparison of effects of transcutaneous electrical nerve stimulation with those of pharmaceutical hyoscine- promethazine compound on pain intensity during the first phase of labor
582
588
FA
Massumeh
Payandeh
Midwifery Department, Nursing and Midwifery School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
m_paiande@yahoo.com
Y
Fatemeh
Nahidi
Midwifery Department, Nursing and Midwifery School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
nahidifateme@yahoo.com
N
Maliheh
Nassiri
Faculty Member, Biostatistics Department, Paramedical Sciences School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
malihenasiri@gmail.com
N
Afsaneh
Fouladi
Kangavar Shahid Chamran Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
afsaneh.fouladi@yahoo.com
N
Background & Aims: Several physical and psychological factors affect the severity and duration of labor pain. Factors such as maternal age, parity, cervical position at the onset of labor, and the relationship between the size and position of the embryo with the size of the canal of delivery are important factors in the severity of labor pain. Effective psychosocial factors that may affect physical factors include fear, anxiety, cultural beliefs and companionship in the delivery room. The severity of pain varies from one person to another, and according to published reports, 15% have mild pain, 35% have moderate pain, 30% have severe pain, and 20% have reported uncommitted pain. Considering the painful nature of labor, the present study was conducted to compare the effect of TENS with hyoscine-promethazine on reducing the frequency of labor pain in the active phase of labor.
Materials & Methods: By a clinical ergometric method, this research was done on 84 eligible pregnant women (42 in TENS group; 42 in hyoscine- promethazine group) referring to Shahid Chamran Hospital of Kangavar city. When active phase of labor began, 20 mg of hyoscine and 25 mg of promethazine were simultaneously administered to the medication group intramuscularly. For TENS group, TENS device was used, with a pair of upper electrodes being between L1-T10 and a pair of lower ones between S2-S4 on both sides of spinal column. Pain scores were studied under per- and post- intervention conditions for 2 groups. Collected data was analyzed by using SPSS software, chi- square test and independent t-test at p<0.05.
Results: Two groups were tested for variables of age, body mass index (BMI), pregnancy age, dilatation at the time of admission, exhibiting no significant differences (p>0.05). The means of contraction duration (p>0.05) and of contraction number (p>0.05) did not differ significantly for 2 groups. But results from comparison of the mean pain scares of 2 groups of studied pregnant women showed that it was significantly lower for TENS group throughout active labor phase at different dilatations than for the other group (hyoscine- promethazine) (p<0.05).
Conclusion: TENS relieves labor pain; therefore, it is recommended to use it for this purpose.
TENS, Hyoscine, Promethazine, Labor pain, The first phase of labor
http://umj.umsu.ac.ir/article-1-4025-en.html
http://umj.umsu.ac.ir/article-1-4025-en.pdf