@article{ author = {einy, sanaz and narimani, mohammad and atadokht, akbar and basharpoor, sajjad and SadeghiMovahhed, farib}, title = {EFFECTIVENESS OF COGNITIVE-ANALYTICAL THERAPY ON EGO-STRENGTH AND OBJECT RELATIONS OF PERSONS WITH BORDERLINE PERSONALITY DISORDER}, abstract ={Background & Aims: Ego-strength and object relations are key concepts in the psychoanalytic approach which are important in the etiology of borderline personality disorder. Therefore, the present study was conducted with the aim of evaluating the effectiveness of cognitive-analytical therapy on ego-strength and object relations of persons with borderline personality disorder. Materials & Methods: This research was a semi-experimental and pretest- posttest design with the control group. The statistical population of this study consisted of all men (N=70) with borderline personality disorder admitted to Isar Psychiatric Hospital and psychiatry section of Fatemi Hospital in 2017 in Ardabil city. The research sample consisted of 30 men with borderline personality disorder selected by convenience sampling and were randomly divided into experimental and control groups. Data collection tools in this study included structured clinical interviews for diagnosis of axis II disorders, Millon clinical multiaxial inventory, psychological inventory ego strength and Bell Object Relations Scale. Pretest and posttest were performed from both groups. Data were analyzed by multivariate analysis of covariance analysis and in SPSS 23 statistical software. Results: The results showed that there was a significant difference between the mean posttest scores of both groups in both ego-strength and object relations variables (p<0/05). Conclusion: Cognitive-analytical therapy is a suitable strategy for improving the ego-strength and object relationships of persons with borderline personality disorder and can be used as an effective intervention method.}, Keywords = {Borderline personality disorder, Cognitive-analytical therapy, Ego-strength, Object relations}, volume = {29}, Number = {1}, pages = {1-11}, publisher = {Urmia University of Medical Sciences}, url = {http://umj.umsu.ac.ir/article-1-4286-en.html}, eprint = {http://umj.umsu.ac.ir/article-1-4286-en.pdf}, journal = {Studies in Medical Sciences}, issn = {2717-008X}, eissn = {2717-008X}, year = {2018} } @article{ author = {Fatahi, Arghavan and Soleimani, Ne}, title = {Evaluation of cytotoxicity activity of cell extracts of kefir microorganisms on glioblastoma cancer cells}, abstract ={Background & Aims: Kefir is a complex composition of microbial species such as streptococci, mesophilic lactobacilli, lactose or non-lactose fermenting yeast and acetic acid bacteria. Numerous studies have been performed to indicate the positive therapeutic effect and healing properties of probiotic products. The aim of this study was to investigate the effect of cytotoxicity of kefir microorganisms’ cytoplasmic extracts on growth and proliferation of glioblastoma cancer cells as the most acute type of brain tumors. Materials & Methods: In this experimental study, kefir microorganisms’ cytoplasmic extract was prepared. The interaction of U87 glioblastoma cancer cells with different concentrations of cell extracts and cell wall of kefir microorganisms was studied. Cell proliferation was evaluated using MTT assay method after 24 and 48 hours. Results: The results of cytotoxicity test show that the highest effect of cell extracts of kefir microorganisms on cancer calls was obtained 0.24 and 0.045 mg of extract at 24 and 48 hours, respectively, and the highest effect of cell wall of kefir microorganisms in both times was a density of 7 mg. Conclusion: The cell extracts of kefir microorganisms as a probiotic product have a higher toxicity and fecundity effect on glioblastoma cells. This combination can be suggested as an alternative candidate for cancer treatment supplement.}, Keywords = {Cell Extract of Kefir Microorganisms, Glioblastoma-Probiotics - Anticancer Effect}, volume = {29}, Number = {1}, pages = {12-19}, publisher = {Urmia University of Medical Sciences}, url = {http://umj.umsu.ac.ir/article-1-4207-en.html}, eprint = {http://umj.umsu.ac.ir/article-1-4207-en.pdf}, journal = {Studies in Medical Sciences}, issn = {2717-008X}, eissn = {2717-008X}, year = {2018} } @article{ author = {khosravian, behrooz and soleimani, esmail}, title = {COMPARISON OF THE EFFECTIVENESS OF TRANSCRANIAL DIRECT CURRENT STIMULATION OF THE BRAIN (TDCS) AND NEUROFEEDBACK ON CRAVING IN SUBSTANCE ABUSERS}, abstract ={Background & Aims: Addiction is a chronic psychiatric disorder that is prevalent in many societies and has become a serious problem for communities. The aim of this study was to compare the effectiveness of transcranial direct current stimulations (tDCS) and neurofeedback on craving among substance users. Materials & Methods: This experimental study was conducted on opioid-dependent patients referring to methadone treatment centers in Miyandob city in 2017. Sixty people were selected through random sampling and were assigned into tDCS (n= 20) and neurofeedback (n= 20) and one control group (n=20). These groups had a pretest and posttest. They all completed a craving questionnaire then treatment with a direct electrical stimulation of the brain (tDCS) started including 20 sessions (20-min) anodal stimulation of F3 region, and Kathodal stimulation of F4 region with a current of 2 mA and treatment sessions with neurofeedback with 20 sessions (30-min).  Finally, all participants completed craving Questionnaire for the second time. The data were analyzed using covariance. Results: There was a significant difference between three groups in the rates of craving in the post-test phase. Also analysis of the data showed that tDCS compared with the neurofeedback was more effective in decreasing the rates of craving in the post-test phase. Conclusion: The results showed that neurofeedback and especially tDCS can reduce craving in substance Users. Hence, we recommend psychotherapists to use tDCS and neurofeedback in treating addicted people.}, Keywords = {tDCS, Neurofeedback ,Craving, Addiction}, volume = {29}, Number = {1}, pages = {20-32}, publisher = {Urmia University of Medical Sciences}, url = {http://umj.umsu.ac.ir/article-1-4269-en.html}, eprint = {http://umj.umsu.ac.ir/article-1-4269-en.pdf}, journal = {Studies in Medical Sciences}, issn = {2717-008X}, eissn = {2717-008X}, year = {2018} } @article{ author = {Nouroozzadeh, Jaffar and valipour, mahsa and ashori, shahrzad and khademvatan, kamal and mohammadzadeh, mir hosei}, title = {RELATIONSHIP BETWEEN XANTHINE OXIDASE AND GLUTATHIONE PEROXIDASE ENZYMES WITH CORONARY ARTERY DISEASE}, abstract ={Background & Aims: Considering the high prevalence of cardiovascular disease among people in the world, the aim of this study was to simultaneously investigate the association between the serum level of xanthine oxidase and glutathione peroxidase enzymes with the severity of coronary artery disease. Materials & Methods: In this case-control study, 85 patients undergoing coronary artery angiography participated and were divided in to the three groups considering the results of angiography by Syntax score as follows: 1. without coronary artery disease (Syntax score = 0); 2. Mild coronary artery disease (Syntax score˂ 22); 3. severe coronary artery disease (Syntax score ≥22). XO was measured by ELISA method and GPX activity assay by Coupled assay. The results were compared using SPSS software version 16. Results: Our results showed that the control group had ejection fraction higher than the other two groups, and the EF was an independent risk factor for the incidence of coronary artery disease (OR = 0.349, P = 0.001). There was a significant difference between the three groups in terms of history of myocardial infarction (OR = 0.332, P = 0.11). Also serum total cholesterol levels were significantly different between the groups (OR = 0.400 and P=0.030). XO value was significantly higher in patients with severe coronary artery stenosis than the other groups but the difference was not statistically significant (P = 0.206). Moreover, with increasing severity of vascular arrest, the level of GPX serum reduced (P =0.539). Conclusion: Overall, our results indicated that there are no independent correlation between XO and GPX factors with the severity of arterial obstruction}, Keywords = {Xanthine Oxidase, Glutathione Peroxidase, Cardiovascular Diseases}, volume = {29}, Number = {1}, pages = {33-38}, publisher = {Urmia University of Medical Sciences}, url = {http://umj.umsu.ac.ir/article-1-4319-en.html}, eprint = {http://umj.umsu.ac.ir/article-1-4319-en.pdf}, journal = {Studies in Medical Sciences}, issn = {2717-008X}, eissn = {2717-008X}, year = {2018} } @article{ author = {HonarmandJahromy, Sahar and Eidi, Maryam and hosseini, Omid and Bolhassani, Elham and Hosseini, Zahra Sadat}, title = {The Prevalence of Gardenerella Vaginalis isolated from patients with bacterial Vaginosis and Nonbacterial Vaginosis referring to the women\'s Gynecologic Clinic of Imam Hossein Hospital}, abstract ={  Background & Aims: Developing bacterial vaginosis is of high prevalence especially in pregnant women. The most common causes of bacterial vaginosis are anaerobic microorganisms such as Gardnerella vaginalis. The aim of this study was to determine the prevalence of Gardenerella vaginalis isolated in women with bacterial and non-bacterial vaginosis. Materials & Methods: The study was conducted on 500 women attending to Gynecology Clinic of Imam Hossein Hospital. Demographic data of patients were studied. Based on Amsel criteria, vaginosis was divided into bacterial and non-bacterial vaginosis groups. For diagnosis of Gardnerella vaginalis isolates, the secretion was cultured in specific Colombia-Agar- medium under anaerobic conditions and after gram staining, biochemical tests were performed. Molecular PCR method was used to identify isolates. Data analysis was performed using SPSS software. Results: Among 220 patients with vaginosis, 56.81% had bacterial and 43% had non bacterial vaginosis. The prevalence of Gardenerella vaginalis was 21.8%. From these, 60.4% and 39.5% were from patients with bacterial and non-bacterial vaginosis, respectively. There was a significant relationship between age group and contraceptive method by IUD with bacterial vaginitis. Conclusion: The High incidence of Gardenerella vaginalis in women with bacterial vaginosis confirms the important role of bacteria in the occurrence of bacterial vaginosis. It is necessary for identification of pathogenic agents responsible for bacterial vaginal infections using culture-based methods to recommend the correct medical treatment in different societies.}, Keywords = { Prevalence, Bacterial vaginosis, non bacterial vaginosis, Gardenerella vaginalis}, volume = {29}, Number = {1}, pages = {39-49}, publisher = {Urmia University of Medical Sciences}, url = {http://umj.umsu.ac.ir/article-1-4225-en.html}, eprint = {http://umj.umsu.ac.ir/article-1-4225-en.pdf}, journal = {Studies in Medical Sciences}, issn = {2717-008X}, eissn = {2717-008X}, year = {2018} } @article{ author = {RezaeianMarjani, Leila and Imani, Mehdi and ZareiJalian, Hossei}, title = {ENGINEERING OF THERAPEUTIC ASPERGILLUS FLAVUS URICASE USING SITE-DIRECTED MUTAGENESIS}, abstract ={Background & Aims: As a therapeutic enzyme, Aspergillus flavus (uricase or; EC 1.7.3.3), is used for treatment of urate deposits, gout and nephropathy, hyperuricemia and tumor lysis syndrom (TLS). Despite desirable kinetic features, fragile stability of uricase limits its wide range applications. Therefore, several approaches have developed such as protein engineering and genetic manipulations to overcome these problems. The main aim of the current research was the design and creation of disulfide bridge in therapeutic enzyme uricase for the first time. Materials & Methods: By the help of bioinformatics studies and based on protein data bank (PDB) code: 1xxj, the potential points for disulfide bridge formation were selected. To create mutations, site-directed mutagenesis using SOE-PCR was employed. Results: According to computational tools, six potential pairs including three intra and three inter-chains were predicted to form disulfide when mutated to cysteins as followings: Ser145-Thr185, Ala235-Val248, His256-Gln281 and Ala6-Cys290, Ser282–Ser282, Asn12-Asp283. By means of SOE-PCR, mutation and cloning of Ala6 and Ser282 was implemented and verified by colony PCR, digestion check and eventually by sequencing. Conclusion: In the current research, we successfully determined the location for mutating to cystein and fortunately implemented mutagenesis by SOE-PCR.}, Keywords = {Uricase, disulfide bond, site-directed mutagenesis, SOE-PCR, gout}, volume = {29}, Number = {1}, pages = {50-62}, publisher = {Urmia University of Medical Sciences}, url = {http://umj.umsu.ac.ir/article-1-4284-en.html}, eprint = {http://umj.umsu.ac.ir/article-1-4284-en.pdf}, journal = {Studies in Medical Sciences}, issn = {2717-008X}, eissn = {2717-008X}, year = {2018} } @article{ author = {Asefi, Masomeh and Nejati, Vahid and Sharifi, Massou}, title = {LINGUISTIC FUNCTIONAL IMPAIRMENT IN CHILDREN WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER}, abstract ={Background & Aims: Most previous studies have shown that the language abilities of children with attention deficit hyperactivity disorder (ADHD) are weaker than normal children. But there is no study that examines the impact of ADHD on all areas of linguistic abilities at the same time. The purpose of this study was to investigate the lack of simultaneous and separately linguistic functions in children with ADHD. Materials & Methods: For this purpose, 163 students from the fourth and fifth grades of primary school in the middle of the city were selected conveniently and randomly. Verbal memory, naming speed, verbal fluency, language ability, reading abilities, attention, attention deficit disorder with hyperactivity were assessed. Results: The results showed that the verbal memory, naming speed, verbal fluency, reading ability, attention at the same time in ADHD children are weaker than normal children (Wilks' λ= 0.153, F(19,143)=41.5, p<0.001). Conclusion: The research showed that language abilities in children with ADHD are separately weaker than normal children and also language abilities in sum were significantly different between them.}, Keywords = { language ability, attention deficit &,,,,, hyperactivity disorder, reading ability, verbal memory}, volume = {29}, Number = {1}, pages = {63-73}, publisher = {Urmia University of Medical Sciences}, url = {http://umj.umsu.ac.ir/article-1-4287-en.html}, eprint = {http://umj.umsu.ac.ir/article-1-4287-en.pdf}, journal = {Studies in Medical Sciences}, issn = {2717-008X}, eissn = {2717-008X}, year = {2018} } @article{ author = {mohammadgoliporagdam, ghazal and letafatkar, amir and hadadnezhad, maliheh}, title = {COMPARISON OF THE SCAPULAR STABILIZATION AND CONSCIOUS CONTROL TRAINING ON SELECTED KINEMATIC OF SCAPULAR IN SUBJECTS WITH SCAPULAR DYSKINESIS}, abstract ={Background & Aims: Scapular orientation and movements can affect the function of the shoulder. Changes in scapular alignment or movement in shoulder regions has the potential to alter the kinetic chain of the body. This study aims at comparing scapular stabilization and conscious control training on selected kinematic of scapular in subjects with scapular dyskinesias. Materials & Methods: A cross-sectional study was conducted with forty four female subjects having scapula dyskinesis (inferior angle & medial border pattern). The subjects were selected and randomly assigned into 3 groups: 1. Stabilization (n=15), 2. Control conscious (n=15), 3. Control (n=14). All the subjects were tested for investigating the degree of disorder in the scapular kinematic (using motion analysis machine). Then the subjects in scapular stabilization and conscious control were trained three days a week for six weeks (45 minutes for each session). In order to analyze the data, a dependent t-test for examining the intergroup difference and a covariance for examining across group difference was applied. Results: The results of the study showed that participating in six weeks of the interventions may result in decreased anterior tilt, internal rotation and improved upward rotation. Significant differences were observed between intervention groups and the control group (p<0.05). There were no changes in the control group before and after the interventions in all dependent variables (p>0.05). Also, concerning all dependent variables significant differences between the experimental groups and the better efficiency of the conscious control training were observed. Conclusion: With reliance on the findings of the research, the use of scapular stabilization program and conscious control program along with other exercise-therapy protocols of shoulder complex is suggested to improving scapular orientation and movements in people with scapular dyskinesias.}, Keywords = {scapula dyskinesias, exercise-therapy, conscious control program}, volume = {29}, Number = {1}, pages = {74-84}, publisher = {Urmia University of Medical Sciences}, url = {http://umj.umsu.ac.ir/article-1-4302-en.html}, eprint = {http://umj.umsu.ac.ir/article-1-4302-en.pdf}, journal = {Studies in Medical Sciences}, issn = {2717-008X}, eissn = {2717-008X}, year = {2018} }