fa مطالعه تغییرات فعالیت‌های پاراکسونازی و آریل‌استرازی آنزیم پاراکسوناز به‌دنبال تجویز عصاره آبی سیر در موش صحرائی آناتومی آناتومی پژوهشي(توصیفی- تحلیلی) Research <p>  <strong>Received: 1 April, 2010 Accepted: 22 May, 2010</strong> </p><p>  <strong>Abstract</strong> </p><p> <strong><i> Background & Aims </i></strong>: <a name="OLE_LINK24">Paraoxonase 1</a> is one of the most significant enzymes scavenging of harmful free radicals and conserves blood lipoproteins against oxidant components. The present study aims to investigate the effects of aqueous garlic extract supplementation <a name="OLE_LINK20">Paraoxonase </a>1. </p><p> <strong><i> Materials & Methods: </i></strong>Twenty normal rats which were divided randomly into two groups including 10 rats for each control and specimen groups. Specimen group received 3 ml of extract interperitoneally each day and the control group received normal saline in the same volume and condition during the experiment. After a week injection, routine blood analysis including Paraoxonase 1 , <a name="OLE_LINK25"></a><a name="OLE_LINK23">Arylesterase </a>activity , and lipid parameters were performed. Oxidant <a name="OLE_LINK26"></a><a name="OLE_LINK19">malondialdehyde </a>and antioxidant (total antioxidant status) parameters were also measured. </p><p> <strong><i> Results: </i></strong>Serum total cholesterol (p<0.05), low-density lipoprotein (p<0.05) and triglyceride (p<0.05) levels were found to be significantly lowered, but Paraoxonase 1 (p<0.05) , Arylesterase (p<0.05) , and HDL (p<0.05) level increased after using the extract. Blood total antioxidant status (p<0.05) values were found to have increased and malondialdehyde (p<0.05) level decreased during this episode. There was a positive and significant correlation between PON and Arylesterase (p=0.025, r=0.697). The correlation between Paraoxonase 1 and HDL-cholesterol concentration was also significant and positive (p=0.006, r=0.794). </p><p> <strong><i> Conclusion </i></strong>: It was concluded that aqueous garlic extract supplementation increases Paraoxonase 1 and Arylesterase improves blood lipid profile and strengthens blood antioxidant potential. It also leads to a decrease in the level of malondialdehyde in blood samples which demonstrates reduced oxidation reactions in the body. </p><p> <strong><i> Keywords: </i></strong>Aqueous garlic extract, Malondialdehyde, Paraoxonase, Arylesterase </p><p>  </p><p> <strong><i> Address: </i></strong>Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. </p><p> <strong> Tel: </strong>(+98) 9141145493 </p><p>  </p><p> <strong><i> Email: </i></strong><a href="mailto:rashtchizadeh@yahoo.com">rashtchizadeh@yahoo.com</a> </p><p>  </p><p> <strong> Source: </strong>U rmia M ed J 2010: 21(2): 297 ISSN: 1027-3727 </p> عصاره­آبی سیر ، مالون دی آلدهید، پاراکسوناز، آریل استراز Aqueous garlic extract, Malondialdehyde, Paraoxonase, Arylesterase 260 266 http://umj.umsu.ac.ir/browse.php?a_code=A-10-3-120&slc_lang=fa&sid=1 Nadere Rashtchizadeh نادره رشتچی‌زاده rashtchizadeh@yahoo.com 370031947532846002802 370031947532846002802 Yes Amir Ghorbanihaghjo امیر قربانی حق‌جو 370031947532846002888 370031947532846002888 No Mohammad Mohsen Mir Momeni محمدحسین میرمومنی 370031947532846002889 370031947532846002889 No Morteza Ghari Ghoran مرتضی قاری قرآن 370031947532846002890 370031947532846002890 No Jaber Hashemzadeh جابر هاشم‌زاده 370031947532846002891 370031947532846002891 No