en جنین شناسی جنین شناسی پژوهشي(توصیفی- تحلیلی) Research <span style="font-size:11pt"><span style="background:#c6d9f1"><span new="" roman="" style="font-family:" times=""><a name="_Toc416081061"></a></span></span><span style="unicode-bidi:embed"><span style="line-height:115%"><span calibri="" style="font-family:"><a name="_Toc416081061"><i>Background & Aims:</i></a> Viral infections during pregnancy can create a serious threat to fetal development. Herpesviridae viruses are among the most common infectious agents during this period. Valacyclovir, a preconstruction of acyclovir, is widely used to treat infections caused by these viruses. considering its ability to cross the placenta and its potential effects on the fetus, this study aimed to investigate the effects of valacyclovir on the morphogenesis and histogenesis of fetal kidneys in pregnant rats.</span></span></span></span><br> <span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:115%"><span calibri="" style="font-family:"><i>&nbsp;</i>Materials & Methods: <i></i></span></span></span></span><br> <span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:115%"><span calibri="" style="font-family:">In this experimental study, 24 pregnant rats were randomly assigned to four groups. The control group no treatment received, while the experimental groups received valacyclovir at 100, 200, and 300 mg/kg of body weight daily. On gestational day 20, the animals were euthanized. Following blood sampling, fetuses were removed and their kidneys were collected. Tissue samples were examined using hematoxylin-eosin, periodic acid-Schiff (PAS), and Masson&rsquo;s trichrome staining methods.</span></span></span></span><br> <span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:115%"><span calibri="" style="font-family:">Results:</span></span></span></span><br> <span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:115%"><span calibri="" style="font-family:">The results showed that increasing doses of valacyclovir significantly reduced crown-rump length and fetal weight. Additionally, kidney size and weight were markedly decreased. Serum levels of creatinine (Cr) and blood urea nitrogen (BUN) were significantly elevated. Furthermore, malondialdehyde (MDA) levels were increased in the third experimental group. Histological assessments revealed structural damage in fetal kidneys, especially in the high-dose treatment groups.</span></span></span></span><br> <span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:115%"><span calibri="" style="font-family:">Conclusion:</span></span></span></span><br> <span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:115%"><span calibri="" style="font-family:">These findings indicate that high doses of valacyclovir can adversely affect fetal growth and kidney development. Therefore, its administration during pregnancy should be approached cautiously.<span lang="AR-SA" dir="RTL" style="font-family:"Arial",sans-serif"></span></span></span></span></span><br> <br> &nbsp; Valacyclovir, Kidney, Fetus, Rat Model 203 208 http://umj.umsu.ac.ir/browse.php?a_code=A-10-5859-2&slc_lang=en&sid=1 Mansoureh daneshfard m.daneshfard98@gmail.com 3700319475328460038472 0009-0008-9198-5074 No Department of basic science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran Majid morovatisharifabad mmorovati@ardakan.ac.ir 3700319475328460038473 3700319475328460038473 Yes Department of Basic Science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran elham salehi esalehi@ardakan.ac.ir 3700319475328460038474 3700319475328460038474 No Department of Basic Science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran mahin dehestani ardakani mdehestani@ut.ac.ir 3700319475328460038475 3700319475328460038475 No Department of Basic Sciences, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran ali Rezaei-Golmisheh arezaei82@gmail.com 3700319475328460038476 3700319475328460038476 No Department of Basic Science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran