en Association of CFI gene polymorphism with age related macular degeneration in Northwest of Iran ژنتیک ژنتیک پژوهشي(توصیفی- تحلیلی) Research <p style="text-align:justify;line-height:18.0pt;"><a name="_Toc416081061"><strong><em><span style="font-size:9.0pt;">Background &&nbsp;Aims:</span></em></strong></a><span style="font-size:9.0pt;"> To investigate the association of <em>CFI</em> p.Gly119Arg</span> <span style="font-size:9.0pt;">polymorphism with Age-related macular degeneration (AMD).</span></p> <p style="text-align:justify;line-height:18.0pt;"><strong><em><span style="font-size:9.0pt;">Materials & Methods:</span></em></strong><span style="font-size:9.0pt;"> In this case-control study, the association of p.Gly119Arg polymorphism in <em>CFI </em>gene was investigated in 65 patients suffering from AMD and150 healthy age, sex and ethnicity matched unrelated people as control group. Both of the case and control groups were originated from Northwest of Iran. Genotypes of both groups were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).</span></p> <p style="text-align:justify;line-height:18.0pt;"><strong><em><span style="font-size:9.0pt;">Results:</span></em></strong><span style="font-size:9.0pt;"> Investigation of the association of p.Gly119Arg polymorphism in <em>CFI</em> gene with AMD showed that there are no statistically significant differences between patients and controls in genotype and allele frequencies of this polymorphism (P˃0/05).</span></p> <p style="text-align:justify;line-height:18.0pt;"><strong><em><span style="font-size:9.0pt;">Conclusion:</span></em></strong><span style="font-size:9.0pt;"> Our result show that p.Gly119Arg</span> <span style="font-size:9.0pt;">polymorphism of the <em>CFI</em> gene is unrelated to the susceptibility to AMD in Northwest of Iran.</span></p> <p><a name="_Toc416081061"><strong><em>Background &&nbsp;Aims:</em></strong></a> To investigate the association of <em>CFI</em> p.Gly119Arg polymorphism with Age-related macular degeneration (AMD).</p> <p><strong><em>Materials & Methods:</em></strong> In this case-control study, the association of p.Gly119Arg polymorphism in <em>CFI </em>gene was investigated in 65 patients suffering from AMD and150 healthy age, sex and ethnicity matched unrelated people as control group. Both of the case and control groups were originated from Northwest of Iran. Genotypes of both groups were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).</p> <p><strong><em>Results:</em></strong> Investigation of the association of p.Gly119Arg polymorphism in <em>CFI</em> gene with AMD showed that there are no statistically significant differences between patients and controls in genotype and allele frequencies of this polymorphism (P˃0/05).</p> <p><strong><em>Conclusion:</em></strong> Our result show that p.Gly119Arg polymorphism of the <em>CFI</em> gene is unrelated to the susceptibility to AMD in Northwest of Iran.</p> AMD , پلی مورفیسم ,ژن CFI AMD, polymorphism, CFI gene 16 21 http://umj.umsu.ac.ir/browse.php?a_code=A-10-2602-1&slc_lang=en&sid=1 neda norouzi neda norouzi n.norouzi67@yahoo.com 3700319475328460018638 3700319475328460018638 No Tabriz University Tabriz University Mortaza Bonyadi Mortaza Bonyadi jabbarpour@tabrizu.ac.ir 3700319475328460018639 3700319475328460018639 Yes Tabriz of University Tabriz of University Esmaeil Babaei Esmaeil Babaei babaei@tabrizu.ac.ir 3700319475328460018640 3700319475328460018640 No Tabriz of University Tabriz of University Mohammad Hossein Jabbarpour Bonyadi Mohammad Hossein Jabbarpour Bonyadi 3700319475328460018641 3700319475328460018641 No Ophthalmic Research Center Shaheed Beheshti University of Medical Sciences & Health Services, Tehran, Iran Ophthalmologist, Ophthalmic Research Center Shaheed Beheshti University of Medical Sciences & Health Services, Tehran, Iran AliReza Javadzadeh AliReza Javadzadeh 3700319475328460018642 3700319475328460018642 No Tabriz University of Medical Scinces Tabriz University of Medical Scinces