fa بررسی نمای بالینی سندرم نفروتیک ایدوپاتیک در کودکان مراجعه‌کننده به مرکز فوق تخصصی نفرولوژی کودکان کرمانشاه بین سال‌های 1380 تا 1390 آناتومی آناتومی پژوهشي(توصیفی- تحلیلی) Research <p class="Chekide" style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><b><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">پیش زمینه و هدف:</span></b><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt"> </span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">سندرم نفروتیک یکی از بیماری‌های قابل توجه دوران کودکی می‌باشد. گرچه مکانیسم پاتوفیزیولوژی آن روشن نیست. اکثر بیماران سیر بالینی خوش‌خیم داشته و به خوبی به استروئیدها پاسخ می‌دهند.<p></p></span></p><p class="Chekide" style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">در</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">این</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">مطالعه</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">به طور گذشته</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">نگر</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">سیما و سیر</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">بالینی</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span dir="rtl"></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span>104</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">کودک</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">مبتلا</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">به</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">سندرم</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">نفروتیک ایدیوپاتیک از</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">سال</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span dir="rtl"></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span>1380</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">تا 1390بررسی</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">شد</span><span dir="ltr"></span><span style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2">. </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA"><p></p></span></p><p class="Chekide" style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><b><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">روش</span></b><span dir="ltr"></span><b><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span></b><b><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">بررسی</span></b><span dir="ltr"></span><b><span style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2">:</font></span></b><span dir="rtl"></span><span style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span> <span lang="FA"><font face="Nazanin" size="2">داده‌های موجود در پرونده پزشکی 104 کودک مبتلا به سندرم نفروتیک ایدیوپاتیک شامل سن شروع بیماری -جنس -پاسخ به استرویید- نتایج بیوپسی کلیه-شیوع نارسایی مزمن کلیه و داروهای مکمل جمع‌آوری شدند. بیماران حداقل شش ماه تحت پیگیری قرار داشتند. که حداقل به مدت شش ماه پی گیری شده بودند، بررسی گردید.</font></span></span><span style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><p></p></span></p><p class="Chekide" style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><b><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">یافته‌ها</span></b><span dir="ltr"></span><b><span style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2">:</font></span></b><span dir="rtl"></span><b><span style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span> </span></b><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">طیف سنی بیماران در زمان مراجعه بین 1 تا16 سال قرار داشت. میانگین سنی 57/5 سال با انحراف معیار 9/3 بود. 63 مورد (5/60 درصد) را پسرها و 41 مورد (5/39درصد) را دخترها تشکیل دادند. 26 مورد مقاوم به استروئید و 78 مورد پاسخ دهنده به استروئید بودند که از بین آن‌ها 39 مورد وابسته به استروئید / عود مکرر بودند. 19 نفر تحت بیوبسی قرار گرفتند که نتیجه آن به شرح زیر بود: بیماری با تغیرات اندک 9 مورد، گلمرولواسکلروز قطعه‌ای ناحیه‌ای پنج مورد، پرولیفراسیون مزانژیالی 2مورد و دو مورد سایر موارد 3 مورد از بیماران (9/2 درصد) دچار نارسایی پایدار کلیه شده بودند.<b><p></p></b></span></p><p class="Chekide" style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><b><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">نتیجه گیری: </span></b><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">اکثر</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">کودکان</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">مبتلا</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">به</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">سندرم</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">نفروتیک</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">ایدیوپاتیک</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">با</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">درمان</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">اولیه</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">استروئید</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">بهبودی پیدا</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">می‌کنند،</span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 10pt mso-fareast-language: EN-US mso-bidi-language: FA"> </span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">عود</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">در</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">آن‌ها</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">شایع</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">بوده و تعداد قابل ملاحظه‌ای از ان‌ها وابسته به استرویید یا با عودهای مکرر خواهند بود. پی</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">گیری</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">طولانی</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">مدت</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">کودکان</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">با</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">سندرم</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">نفروتیک</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">اولیه</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">لازم</span><span dir="ltr"></span><span lang="FA" style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA">می‌باشد</span><span dir="ltr"></span><span style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2">.</font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-fareast-language: EN-US mso-bidi-language: FA"><p></p></span></p><p class="Chekide" style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><b><span style="mso-fareast-language: EN-US mso-bidi-language: FA" dir="ltr"><font face="Times New Roman" size="2"></font></span></b></p><p class="Chekide" style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><p> </p></span></p> <p>  <strong></strong></p><p> <i> <strong>Background & Aims</strong> </i>: Nephrotic syndrome is one of the important diseases of childhood. Although physiopathology of the disease is not well understood but vast majority of patients have a benign course with good response to steroids. In this retrospective study, we reviewed clinical feature and course of 104 children with idiopathic nephrotic syndrome during 2001-2011 . </p><p> <strong><i> Materials & Methods </i></strong>: The data including age at presentation, gender, response to steroid, results of renal biopsy, frequency of end stage renal disease and adjuvant drugs were collected from patients' medical records. Patients completed at least a 6 month follow up . period </p><p> <strong><i> Results </i></strong><strong>: </strong>The range of age at presentation was 1-16 years (mean 5.57 {3.9} years). Patients included 63 (60.5%) male and 41 (39.5%) female. Twenty-six patients were steroid resistant, 78 steroid responsive and 39 frequently relapser/steroid dependent. Nineteen patients underwent needle renal biopsy. Pathologic examination revealed minimal change disease in 9, focal segmental sclerosis in 5, mesangial proliferation in 2 and other findings in 2 patients. Course of disease ended to end stage renal disease in 3 (2.9%).<strong></strong> </p><p> <strong><i> Conclusion </i></strong>: A vast majority of children with idiopathic nephrotic syndrome had complete remission with primary course of steroid. However, relapse was common and a considerable number of patients experienced steroid dependency or frequent relapses. Long term follow up is necessary . </p><p>  </p><p>  SOURCE: URMIA MED J 2014: 24(11): 932 ISSN: 1027-3727 </p> سندرم نفروتیک، حساس به استروئید، مقاوم به استروئید Nephrotic syndrome, Steroid resistant, Frequently relapser 927 932 http://umj.umsu.ac.ir/browse.php?a_code=A-10-582-430&slc_lang=fa&sid=1 Abolhassan Seyedzadeh سیدابوالحسن سیدزاده asayedzadeh@kums.ac.ir 370031947532846008616 370031947532846008616 Yes Urology and Nephrology Research Center, Kermanshah University of Medical Sciences, مرکز تحقیقات ارولوژی و نفرولوژی، دانشگاه علوم پزشکی کرمانشاه Ehsan Alimohammadi احسان علیمحمدی 370031947532846008617 370031947532846008617 No Urology and Nephrology Research Center, Kermanshah University of Medical Sciences, مرکز تحقیقات ارولوژی و نفرولوژی، دانشگاه علوم پزشکی کرمانشاه Akram Soleimani اکرم سلیمانی 370031947532846008618 370031947532846008618 No Urology and Nephrology Research Center, Kermanshah University of Medical Sciences, مرکز تحقیقات ارولوژی و نفرولوژی، دانشگاه علوم پزشکی کرمانشاه