Studies in Medical Sciences
مجله مطالعات علوم پزشکی
Studies in Medical Sciences
Medical Sciences
http://umj.umsu.ac.ir
37
journal37
2717-008X
2717-008X
10.61186/umj
fa
jalali
1391
7
1
gregorian
2012
10
1
23
4
online
1
fulltext
fa
بررسی ارتباط سطح هموسیستئین سرم با تراکم استخوانی در خانمهای یائسه مبتلا به استئوپروز
A SURVEY ON EFFECT OF HOMOCYSTEINE IN REDUCTION OF BONE DENSITY IN POSTMENOPAUSAL WOMEN
آناتومی
آناتومی
پژوهشي(توصیفی- تحلیلی)
Research
<p class="Chekide" style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% TEXT-INDENT: -0.05pt MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><b><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">پیش زمینه و هدف: </span></b><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">استئوپروز شایعترین بیماری متابولیک استخوان است که با کاهش استحکام استخوان مشخص میشود. این مطالعه به منظور ارزیابی ارتباط سطح هموسیستنین سرم با تراکم استخوانی در خانمهای یائسه انجام شد. <p></p></span></p><p class="Chekide" style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% TEXT-INDENT: -0.05pt MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><b><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">مواد و روش کار: </span></b><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">این مطالعه به صورت </span><font size="2"><font face="Times New Roman"><span dir="ltr">Case Control</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> روی زنان بالای 50 سال که از طریق بررسی پرونده در دو گروه بیماران </span><font size="2"><font face="Times New Roman"><span dir="ltr">BMI T Score < -2.5</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> و کنترل 1-</span><span lang="FA" style="FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-font-family: 'Times New Roman' mso-bidi-language: FA"><font face="Times New Roman">≤</font></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"> </span><font size="2"><font face="Times New Roman"><span dir="ltr">BMI</span><span lang="EN-AU" style="mso-ansi-language: EN-AU" dir="ltr"> T.</span><span dir="ltr"> Score</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> جای گرفتند انجام شد. سطح هموسیستئین در هر دو گروه چک و نتایج آزمایشگاه و اطلاعات دموگرافیکی بیماران با نرم افزار </span><font size="2"><font face="Times New Roman"><span dir="ltr">SPSS -18</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> و آزمونهای آماری مورد تجزیه و تحلیل قرار گرفت.<p></p></span></p><p class="Chekide" style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% TEXT-INDENT: -0.05pt MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><b><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">یافتهها:</span></b><span dir="ltr"></span><b><span lang="FA" style="mso-bidi-language: FA" dir="ltr"><span dir="ltr"></span><font face="Times New Roman" size="2"> </font></span></b><span dir="rtl"></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span>200 بیمار وارد مطالعه شدند. نتایج نشان میدهند که شدت ارتباط بین سن و هموسیتئین و گروه کنترل از نظر آماری </span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">معنیدار</span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"> </span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">نیست (65/0 </span><font size="2"><font face="Times New Roman"><span dir="ltr">P=</span><span dir="rtl"></span></font></font><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt"><span dir="rtl"></span>)</span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"> همچنین در گروه بیماران این ضریب همبستگی نیز </span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">معنیدار</span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"> </span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">نمیباشد (24/0= </span><font size="2"><font face="Times New Roman"><span dir="ltr">P</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span>). به ازای یک سال افزایش سن فرد </span><font size="2"><font face="Times New Roman"><span dir="ltr">µmol/dl</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> 51/0 به میزان هموسیستئین اضافه میشود که از نظر آماری </span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">معنیدار</span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"> </span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">نمیباشد (32/0= </span><font size="2"><font face="Times New Roman"><span dir="ltr">P</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span>) همچنین میزان اثر بیماری در مقایسه با گروه کنترل </span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">معنیدار</span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"> </span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">بود (001/0= </span><font size="2"><font face="Times New Roman"><span dir="ltr">P</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span>). میانگین و انحراف استاندارد هموسیستئین در گروه بیماران به ترتب 5/10 و 43/0 و در گروه کنترل 57/7 و 3/0 میکرومول در دسی لیتر میباشد که از نظر آماری </span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">معنیدار</span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"> بود (001/0</span><font size="2"><font face="Times New Roman"><span dir="ltr">P<</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span>) میانگین و انحراف استاندارد </span><font size="2"><font face="Times New Roman"><span dir="ltr">BMD</span><span dir="rtl"></span></font></font><span style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> </span><span dir="ltr"></span><span dir="ltr"><span dir="ltr"></span><span style="mso-spacerun: yes"><font face="Times New Roman" size="2"> </font></span></span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">در گروه بیماران به ترتیب 95/2- ±11/0 و در گروه کنترل 128/0±085/0 گرم در سانتیمتر مربع میباشد. میانگین و انحراف استاندارد </span><font size="2"><font face="Times New Roman"><span dir="ltr">BMI</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> در بیماران به ترتیب 54/0 ± 04/28 و در گروه کنترل 43/0 ± 41/30 بود که از نظر آماری نیز </span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt">معنیدار</span><span lang="AR-SA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"> </span><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">میباشد (001/0</span><font size="2"><font face="Times New Roman"><span dir="ltr">P<</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span>).</span><span style="mso-bidi-language: FA" dir="ltr"><p></p></span></p><p class="Chekide" style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% TEXT-INDENT: -0.05pt MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><b><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA">نتیجه گیری:</span></b><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"> این مطالعه نشان داد که هموسیستئین میتواند به عنوان یک </span><font size="2"><font face="Times New Roman"><span dir="ltr">Risk factor</span><span dir="rtl"></span></font></font><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"><span dir="rtl"></span> برای استئوپروز در زنان سالمند یائسه در نظر گرفته شود. <p></p></span></p><p class="Chekide" style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% TEXT-INDENT: -0.05pt MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><span lang="FA" style="FONT-FAMILY: Nazanin FONT-SIZE: 9.5pt mso-ansi-font-size: 8.5pt mso-bidi-language: FA"></span></p>
<p class="Abstract" style="MARGIN: 0in 0in 0pt"><span lang="EN-GB" style="mso-ansi-language: EN-GB"><p><strong><font face="Times New Roman" size="3"> </font></strong></p></span></p><p class="Amatnmagale" style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt"><font face="Times New Roman"><font size="3"><strong><i>Background & Aims</i>: </strong>Osteoporosis is the most common metabolic bone disease that is characterized by reduced bone strength. This study evaluated the effect of homocysteine in reduction of bone density in postmenopausal women over age 50.</font></font></p><p class="Amatnmagale" style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt"><font size="3"><font face="Times New Roman"><b><i>Materials & Methods</i>: </b>This case control study was done on women over 50 years by reviewing<span style="mso-spacerun: yes"> </span>patients’<span style="mso-spacerun: yes"> </span>bone densitometry reports and were divided into two groups . The<span style="mso-spacerun: yes"> </span>BMI T score <-2.5 as case group and<span style="mso-spacerun: yes"> </span>1 - ≤ BMI T as control one. Two hundred patients whose bone densitometry was done for them in the past five years were enrolled in the study. The level of homocysteine was evaluated<span style="mso-spacerun: yes"> </span></font><span style="FONT-FAMILY: "Cambria Math","serif" mso-bidi-font-family: 'Cambria Math'"></span><font face="Times New Roman">in both groups and laboratory results and demographic data of patients were collected in checklists and analyzed with software SPSS.</font></font></p><p class="Amatnmagale" style="TEXT-ALIGN: justify MARGIN: 0in 0in 0pt"><font size="3"><font face="Times New Roman"><b><i>Results</i>: </b>The data analysis indicated that the relationship between age and homocysteine and control groups was not statistically significant (P= 0.65) and also the correlation coefficient was not significant. (P= 0.24) Using linear regression models to assess the relationship between age and homocysteine </font><span style="FONT-FAMILY: "Cambria Math","serif" mso-bidi-font-family: 'Cambria Math'"></span><font face="Times New Roman">in the presence of the patient control group results showed that for every one year increase in age 0.51 μmol/dl is added to the amount of homocysteine, which is not statistically significant (P = 0.32) also compared rates of disease control after removing the effect of age in a linear regression model showed that this effect is significant (P = 0.001). The mean and standard deviation of homocysteine </font><span style="FONT-FAMILY: "Cambria Math","serif" mso-bidi-font-family: 'Cambria Math'"></span><font face="Times New Roman">in patients were 10.5, 0.43 and in control group were 7.57 and 0.3<span style="mso-spacerun: yes"> </span>micromole/dL respectively, which was statistically significant. (P </font><span style="FONT-FAMILY: "Cambria Math","serif" mso-bidi-font-family: 'Cambria Math'">˂</span><font face="Times New Roman"> 0.001) The mean ± standard deviation of BMD in patients group was -2.95 ± 0.11 and in control groups was 0.085 ± 0.128 gr/cm<sup>2</sup>. The mean ± standard deviation of BMI in patients was 28.04 ± 0.54 and in the control group was <span dir="rtl"></span><span lang="FA" style="mso-bidi-language: FA" dir="rtl"><span dir="rtl"></span><span style="mso-spacerun: yes"> </span></span><span dir="ltr"></span><span dir="ltr"></span>30.41± 0.43, which was statistically significant. (P </font><span style="FONT-FAMILY: "Cambria Math","serif" mso-bidi-font-family: 'Cambria Math'">˂</span><font face="Times New Roman"> 0.001)</font></font></p><p class="Amatnmagale" style="MARGIN: 0in 0in 0pt"><font size="3"><font face="Times New Roman"><b>Concl<i>u</i>sion</b>: This study showed that homocysteine </font><span style="FONT-FAMILY: "Cambria Math","serif" mso-bidi-font-family: 'Cambria Math'"></span><font face="Times New Roman">could be considered as a risk factor for osteoporosis in postmenopausal elderly women.</font></font><font size="3"><font face="Times New Roman"> </font></font></p><p align="center" class="Amatnmagale" style="TEXT-ALIGN: center MARGIN: 0in 0in 0pt"><font size="3"><font face="Times New Roman"><b>SOURCE</b>: URMIA MED J 2012: 23(4): 454 ISSN: 1027-3727</font></font></p>
تراکم استخوان، استئوپروز، منوپوز (یائسگی)، هموسیستئین
Bone density, Osteoporosis, Menopause, Homocysteine
427
431
http://umj.umsu.ac.ir/browse.php?a_code=A-10-582-275&slc_lang=fa&sid=1
Ali Reza
Mehdizade
علیرضا
مهدی زاده
370031947532846005875
370031947532846005875
No
Faculty of Medicine, Urmia University of Medical Sciences
دانشگاه علوم پزشکی ارومیه
Mir Amir
Aghdashi
میرامیر
آغداشی
370031947532846005876
370031947532846005876
No
Faculty of Medicine, Urmia University of Medical Sciences
دانشگاه علوم پزشکی ارومیه
Neda
Valizadeh
ندا
ولی زاده
370031947532846005877
370031947532846005877
No
Faculty of Medicine, Urmia University of Medical Sciences
دانشگاه علوم پزشکی ارومیه
Pouya
Eslampoor
پویا
اسلامپور
370031947532846005878
370031947532846005878
No
Urmia University of Medical Sciences
دانشگاه علوم پزشکی ارومیه
Negar
Hosseinzade
نگار
حسین زاده
negar.hoseinzade@yahoo.com
370031947532846005879
370031947532846005879
Yes
Student Research Committee, Urmia University of Medical Sciences
کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی ارومیه