TY - JOUR T1 - EVALUATION OF THE EFFECT OF EXPERIMENTAL ALCOHOLISM ON TESTIS TISSUE AND SPERM GUALITY IN ADULT MOUSE MODEL TT - بررسی اثر الکلیسم تجربی بر ساختار بیضه و تأثیر آن بر کیفیت منی در مدل موش سوری بالغ JF - URMIAMJ JO - URMIAMJ VL - 26 IS - 2 UR - http://umj.umsu.ac.ir/article-1-2776-en.html Y1 - 2015 SP - 112 EP - 120 KW - Alcoholism KW - Testis KW - Spermatogenesis KW - Sperm KW - Mouse N2 -     Back ground & Aims : This study was designed to determine the effects of alcohol administration on sperm quality and testicular tissue pathogenesis.   Materials & Methods : In this study, 20 male adult mice were divided into two groups as control (saline normal) and test (ethanol 3g/kg BW as 25% V/V). The rats were given by gastric intubation, daily for 45 days and then all the animals were sacrificed and testes were dissected out and underwent histopathological studies. Sperm samples were collected from caudal epididyms in order to evaluate sperm parameters.   Results : Percentage of seminiferous tubules with positive TDI, SPI, RI and leydig cells NO/mm2 of connective tissue and sertoli cells NO/tubule significantly decreased in alcoholic group. Light microscopic analysis of sperm parameters demonstrated that sperm motility, viability and count remarkably decreased in the test group in comparison with the controls. Moreover, the percentage of sperms with DNA disintegrity, nuclear immaturity and morphologic immaturity significantly increased in the alcoholic group compared with the control (P M3 ER -