AU - Rezaei, Roqieh AU - Sadraie, Seyed Homayoon AU - Kaka, Gholamreza AU - Mofid, Mahmoud AU - Hassanzadeh, Zabihullah TI - HISTOMORPHOMETRIC AND IMMUNOHISTOCHEMICAL EVALUATION OF CELL TRANSPLANTATION ON THE REPAIR OF BONE DEFECTS IN RAT PT - JOURNAL ARTICLE TA - URMIAMJ JN - URMIAMJ VO - 25 VI - 5 IP - 5 4099 - http://umj.umsu.ac.ir/article-1-2324-en.html 4100 - http://umj.umsu.ac.ir/article-1-2324-en.pdf SO - URMIAMJ 5 AB  -     Background & Aims : Bone marrow stromal cells (BMSCs) are multipotent stem cells that can proliferate and differentiate into osteogenic cells . T his study aimed to investigate the effects of BMSCs transplantation for the repair of bone defects in rat.  Materials & Methods : In this study twenty-eight male adult rats were equally divided into 4 groups. Group 1 ( control group) received no treatment after bone defect after bone defect the culture medium was injected at the site of bone defect for group 2 ( sham group) group 3 was non-autologous cell transplantation group and group 4 was autologous cell transplantation group. Bone histomorphometric evaluation s and cell counting were performed in all groups.   Results : No significant differences were found between the control group and Sham according to histomorphometric study. The mean trabecular surface was significantly increased in autologous and non-autologous groups compared to the control group. In addition, mean number of osteocytes was increased in autologous and non-autologous groups when compared to the control group.   Conclusion : It seems that both autologous and non-autologous BMSCs transplantation appears to be effective in the repair of bone defect.     SOURCE: URMIA MED J 2014: 25(5): 424 ISSN: 1027-3727 CP - IRAN IN - Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran LG - eng PB - URMIAMJ PG - 414 PT - Research YR - 2014