TY - JOUR JF - URMIAMJ JO - Studies in Medical Sciences VL - 23 IS - 2 PY - 2012 Y1 - 2012/6/01 TI - ENHANCED NEUROPATHIC PAIN FOLLOWING INTRASPINALY INJECTION OF BONE MARROW STROMAL CELLS IN CONTUSION MODEL OF SPINAL CORD INJURY TT - پیدایش دردهای نوروپاتیک پس از درمان مدل تجربی آسیب نخاعی در موش با کمک پیوند سلول‌های بنیادین مغز استخوان N2 - Background & Aims: Nowadays stem cell therapy is the common methods for treatment of spinal cord injury (SCI). Studies have shown that although transplantation of Neural Stem Cells (NSCs) in injured spinal cord promotes motor function but leads to development of neuropathic pain (NP). Since bone marrow stromal cells (BMSCs) are commonly used in treatment of SCI, we sought to investigate whether intraspinaly injection of these cells develop NP.Materials & Methods: Adult female wistar rats (n=24) were used. BMSCs were cultured and prelabeled with Brdu. Contusion model of SCI was performed at T8-9 level using New York University Device. The rats were divided into the three groups of 8 animals including: a control group, an experiment group and a sham group. In control group only a laminectomy was performed, the experiment group received (3×105 BMSCs) intraspinaly seven days after injury. The sham group received serum in the same way. Locomotion was assessed using BBB test and NP was assessed by withdrawal threshold test weekly and for eight weeks. Results: Significant improvement was observed in the BBB scores in experiment group (P SP - 123 EP - 132 AU - Pourheydar, Bagher AU - Joghataei, Mohammad Taghi AU - Soleimani, Mansoor AU - Pirhajati, Vahid AU - Pourheydar Pourheydar, Maryan AD - Faculty of Medicine, Urmia university of Medical Sciences, Urmia, Iran KW - Bone marrow stromal cell KW - Spinal cord injury KW - Neuropathic pain UR - http://umj.umsu.ac.ir/article-1-1322-en.html ER -