TY - JOUR JF - URMIAMJ JO - Studies in Medical Sciences VL - 30 IS - 6 PY - 2019 Y1 - 2019/9/01 TI - COMPARISON OF THE EFFECT OF SODIUM VALPROATE AND LEVETIRACETAM ON THE PREVENTION OF MIGRAINE HEADACHES: A PROSPECTIVE STUDY TT - مقایسه تأثیر لوتیراستام و والپروات سدیم در پیشگیری از سردردهای میگرنی: یک مطالعه آینده‌نگر N2 - Background & Aims: Preventive treatment of migraine headaches is performed after careful and complete examination of the number and quality of headaches in the patient to improve the patient's quality of life and avoid unpleasant side effects. This study was conducted to evaluate the efficacy of two drugs of levetiracetam and sodium valproate on preventive treatment of migraine headaches. Materials & Methods: In this prospective study, 35 patients with migraine headache who met the preventive treatments criteria and underwent at least 12 weeks of sodium valproate treatment at a dose of 1000 mg daily and did not responded to treatment were randomly selected and included in the study and their drug was changed to levetiracetam at a dose of 500 mg daily. All patients were visited 6 weeks and 12 weeks later in terms of the number, severity, duration and quality of headaches and the data was recorded in the relevant forms. Finally, all data was entered into SPSS software and analyzed. Results: 35 patients participated in this study, among which 40% were male and 60% were female. The mean age of the patients was 32.51 ± 10.90 years. In this study, according to the results of the repeat measure, it was concluded that levetiracetam drug reduces both the severity and the number of migraine headaches in the patients who have shown resistance to sodium valproate (P = 0.001). Conclusion: It seems that levetiracetam is an appropriate option to treat migraine headache in the patients who have shown resistance to sodium valproate or the probability of side effects of sodium valproate is high in the disease. SP - 421 EP - 427 AU - Nazarbaghi, Surena AU - Mosarrezaii Aghdam, Arash AU - Ahmadi Salmasi, Babak AU - Memarzadeh, Salar AD - Assistant Professor of Neurological Disorders, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author KW - migraine headaches KW - preventive treatment KW - levetiracetam KW - sodium valproate UR - http://umj.umsu.ac.ir/article-1-4832-en.html ER -