TY - JOUR T1 - THE EFFECT OF FOUR WEEKS' VOLUNTARY EXERCISE ON A REGULAR AND COMPLEX WHEEL RUNNING ON NG2 BRAIN LEVELS IN HEALTHY MALE WISTAR RATS TT - اثر چهار هفته تمرین اختیاری روی چرخ دوار معمولی و پیچیده بر سطوح NG2 مغز رت‌های نر سالم نژاد ویستار JF - URMIAMJ JO - URMIAMJ VL - 29 IS - 12 UR - http://umj.umsu.ac.ir/article-1-4534-en.html Y1 - 2019 SP - 896 EP - 903 KW - voluntary Exercise KW - regular wheel running KW - complex wheel running KW - NG2 N2 - Background and objective: NGF-2 is oligodendrocyte progenitor cell which has neuroprotective functions. This study was designed to investigate and compare the effect of a 4-week voluntary training program on regular and complex running wheels on NGF-2 levels in healthy Wistar male rats. Materials and methods: Thirty adult Wistar male rats were divided into 3 groups: voluntary training on regular running wheel, voluntary training on complex running wheel, and control. For measuring the NGF-2 levels in the brain, the ELISA test was used. One-way analysis of variance and Tuckey post-hoc tests were employed for comparing the intergroup differences. All the statistical analysis were conducted by SPSS software (version 20). Results: Performing voluntary training programs on regular (p=0.03) and complex running wheels (p=0.001) resulted in significant changes in NGF-2 levels in the brain. There was also a significant difference between these two modes of training programs (p=0.05). Conclusion: Based on the results, these 2 training protocols can be regarded as positive intervening factors for increasing oligodendrocytes in healthy rats, although the complex running wheel voluntary training has shown to be more promising. M3 ER -