TY - JOUR JF - URMIAMJ JO - Studies in Medical Sciences VL - 26 IS - 6 PY - 2015 Y1 - 2015/9/01 TI - EFFECT OF INTRA PERITONEAL INJECTION OF HISTIDINE ON COLD ALLODYNIA, FORMALIN PAIN TEST AND PATHOLOGY OF CRUSHED SCIATIC NERVE IN RAT TT - اثر تزریق داخل صفاقی هیستیدین بر آلودینی سرما، آزمون درد فرمالین و آسیب‌شناسی عصب سیاتیک له‌شده در موش صحرایی N2 -       Background & Aims: Protective effect of histidine on nervous system is well studied. We aimed to evaluate the efficiency of cold allodynia and formalin pain tests with pathology in histidine injection as intra peritoneal method in rat’s crushed sciatic nerve.     Materials & Methods: 57 rats were used for evaluating cold allodynia and formalin pain tests. Histopathological sections were stained with two staining methods. Numbers of schwann cells and myelinated nerve fibers were evaluated for repair processing.     Results:  Cold allodynia and formalin pain tests in histidine 400mg/kg group had the best results and most likeness with pathology. In this group, cold allodynia was started on the 7th day after lesion creation in sciatic nerve and achieved to maximum on the 14th and 28th days and then decreased till the end of the experiment (42nd  day) and compared with the control group (p SP - 531 EP - 541 AU - Amniattalab, Amir AU - Tamaddonfard, Esmail AU - Cheraghian, Siamak AU - Dorostghol, Ahad AU - Babadoust-Sani, Elham AU - Mehr, Mehrzad AU - Najafi, Zohre AD - Pathology Department, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran KW - Cold allodynia KW - Formalin pain test KW - Histidine KW - Crushed sciatic nerve KW - Rat UR - http://umj.umsu.ac.ir/article-1-2989-en.html ER -