TY - JOUR JF - URMIAMJ JO - Studies in Medical Sciences VL - 28 IS - 9 PY - 2017 Y1 - 2017/12/01 TI - ASSOCIATION OF VITAMIN D STATUS AND BSMI POLYMORPHISM IN VITAMIN D RECEPTOR GENE WITH HASHIMOTO DISEASE IN URMIA TT - بررسی ارتباط بین وضعیت ویتامین D و پلی مورفیسم BsmI ژن گیرنده ویتامین D با بیماری هاشیموتو در شهر ارومیه N2 - Background & Aims: The hashimoto thyroiditis as a common autoimmune thyroid disease have a multifactorial etiology. Vitamin D status and vitamin D receptor gene BsmI polymorphism are involved in hashimoto developing. The aim of this research was to study the association between 25hydroxy vitamin D serum levels and BsmI polymorphism with hashimoto. Materials & Methods: We conducted a case-control study of 105 adults with hashimoto thyroiditis and 105 matched healthy controls. BsmI polymorphism was investigated by PCR-RFLP. Moreover, after matching two groups for vitamin D intakes from diet and sun exposure habits, serum levels of 25-hydroxyvitamin D as vitamin D status were measured by electrochemiluminescence immunoassay. Data were analyzed with chi-square test, odds ratio, ANOVA, Mann-Whitney U test and independent t-test. Results: Vitamin D deficiency (≤20ng/ml) was associated with higher susceptibility to hashimoto compared with vitamin D sufficiency (≥30ng/ml) (P = 0.02; adjusted OR = 2.74 CI 95%, 1.2-6.25). BsmI-"GG" genotype was higher in hashimoto group (P = 0.01). BsmI polymorphisms were not effective in vitamin D status (P> 0.05). Conclusion: Our results revealed that vitamin D status and BsmI polymorphisms are involved in susceptibility to hashimoto disease. Further investigations of the relationship between VDR gene polymorphisms with hashimoto and vitamin D status are needed. SP - 572 EP - 581 AU - Faghfouri, Amir Hossein AU - Bagheri, Morteza AU - Mehdizadeh, Alireza AU - Ayremlou, Parvin AU - Teymour Azar, Mahsa AU - Zarrin, Rasoul AD - Urmia University of Medical Sciences KW - Vitamin D receptor KW - gene polymorphism KW - BsmI KW - vitamin D KW - Hashimoto UR - http://umj.umsu.ac.ir/article-1-4019-en.html ER -