TY - JOUR JF - URMIAMJ JO - Studies in Medical Sciences VL - 20 IS - 2 PY - 2009 Y1 - 2009/9/01 TI - DIAGNOSTIC VALUE OF AgNOR STAINING AND KI-67 (MIB1) EXPRESSION IN UTERINE SMOOTH MUSCLE TUMORS TT - بررسی ارزش تشخیصی رنگ آمیزی AgNOR و میزان بروز((MIB1 Ki_67 در تومرهای عضله صاف رحم N2 -   Abstract  Background & Aims: Uterine smooth muscle tumors are the most common human neoplasm. They are divided clinically as benign and malignant but there is another group of lesions which is difficult to place in these two categories, so-called STUMP and differentiation of these tumors on the basis of H&E staining is difficult. The goal of this study is to find distinguishing objective biomarker and a survey of proliferation markers comparing these three groups of tumors.  Materials &Methods: Twenty one cases in each group of the above mentioned tumors were selected randomly from pathobiology laboratories and studied by using IHC staining for Ki_67 expression and AgNOR method. Results: Ki_67 was expressed in 63.15% of leiomyosarcomas, 4.76% of STUMPs and 0% of leiomyoma group. Ki_67 expression between leiomyosarcoma and STUMP, and also between leiomyosarcom and leiomyoma were significant (P SP - 111 EP - 116 AU - A Javadirad, AU - S H Madani, AU - S Khazaei, AU - M Rahbar, AD - KW - Nucleolar organizer regions KW - AgNOR KW - Uterine smooth muscle tumor KW - Ki_67 UR - http://umj.umsu.ac.ir/article-1-431-en.html ER -