TY - JOUR T1 - THE EFFECT OF TWO MONTHS OF CHIA SUPPLEMENTATION ON INFLAMMATORY AND ANTI-INFLAMMATORY RESPONSES IN WISTAR DIABETIC MALE RATS TT - تأثیر دو ماه مکمل دهی چیا بر پاسخ‌های التهابی و ضدالتهابی در رت‌های نر دیابتی نژاد ویستار JF - URMIAMJ JO - URMIAMJ VL - 32 IS - 2 UR - http://umj.umsu.ac.ir/article-1-5111-en.html Y1 - 2021 SP - 116 EP - 123 KW - Interleukin-1 beta KW - Interleukin-13 KW - Herbal Supplements KW - Inflammation KW - Anti-Inflammatory Agents N2 - Background & Aims: Increased inflammation is a consequence of diabetes. Accordingly, the use of herbal medicine as a solution has been suggested. The objective of this study was to evaluate the effect of two months of chia supplementation in conjunction with inflammatory and anti-inflammatory responses in male Wistar diabetic rats. Materials & Methods: 36 diabetic rats were randomly assigned to 3 equal groups (control group, diabetes group, diabetes + chia group) and were subjected to 8 weeks of supplementation. Interleukin-1 and interleukin-13 were measured in soleus muscle tissue to examine the inflammatory and anti-inflammatory indicators. ANOVA and Tukey's post hoc test were used for data analysis. Results: Although chia supplementation had aggravating effects on IL-1ß compared with the diabetic group, this effect was not statistically significant (p = 0.99). Also, IL-13 protein expression increased significantly in the diabetic control group by about 51% (p = 0.001), and in the diabetic group with chia supplementation by about 50% (p= 0.001) compared to the healthy control group. There was no significant difference between the two groups. Conclusion: It seems that two months of chia supplementation with this dose and period of consumption could not have a positive effect on anti-inflammatory factors in male diabetic rats. Confirmation of this finding requires further research in this area. M3 ER -