Volume 33, Issue 5 (August 2022)
Studies in Medical Sciences 2022, 33(5): 322-335 |
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Bahram M E, Afroundeh R, Pourvaghar M J, Seyfi F, Katebi L. STUDYING THE SIMULTANEOUS EFFECT OF COMBINED EXERCISES AND SUPPLEMENTATION OF MULBERRY LEAF EXTRACT ON SOME INFLAMMATORY BIOMARKERS EFFECTIVE IN THE PATHOGENESIS OF DIABETES AND HBA1C IN ELDERLY MEN WITH TYPE 2 DIABETES. Studies in Medical Sciences 2022; 33 (5) :322-335
URL: http://umj.umsu.ac.ir/article-1-5824-en.html
URL: http://umj.umsu.ac.ir/article-1-5824-en.html
Mohammad Ebrahim Bahram 
, Roghayeh Afroundeh * , Mohammad Javad Pourvaghar , Farnaz Seyfi , Leila Katebi
, Roghayeh Afroundeh * , Mohammad Javad Pourvaghar , Farnaz Seyfi , Leila Katebi
Associate Professor of Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran , afroundeh@uma.ac.ir
Abstract: (1058 Views)
Background and Aims: Adipokines play an important role in inflammation and pathogenesis of diabetes. The aim of this study was to study the simultaneous effect of combined exercises (aerobic + resistance) and the consumption of mulberry leaf extract on the serum levels of galectin-3, apelin, and HbA1C in elderly men with type 2 diabetes
Materials and Methods: In this semi-experimental and single-blind research, 40 elderly men with the age range of 67.07 ± 7.48 years were purposefully selected and randomly divided into five equal groups (exercise, supplement, Supplement+exercise, placebo, and control). A daily dose of 1000 mg (two 500 mg capsules) of Mulberry leaf extract was used 3 times a day for 2 months. The exercise and exercise + supplement groups practiced for 8 weeks in 3 sessions, each week for 90 minutes. The studied variables were measured 24 hours before and 48 hours after the intervention period.
Results: Galectin-3, apelin, and HbA1C levels in the post-test of the exercise, exercise+supplement, and supplement groups were significantly reduced compared to the pre-test (P<0.05). Also, the results of covariance analysis showed that the levels of galectin-3, apelin, and HbA1C in the exercise, exercise+supplement and supplement groups were significantly reduced compared to the placebo and control groups (P<0.05).
Conclusion: It seems that combined exercises and consumption of Mulberry leaf extract can be effective in reducing inflammatory biomarkers effective in the pathogenesis of diabetes in the elderly with type 2 diabetes. However, supplementing with combined exercise has the greatest effect on controlling these inflammatory markers.
Materials and Methods: In this semi-experimental and single-blind research, 40 elderly men with the age range of 67.07 ± 7.48 years were purposefully selected and randomly divided into five equal groups (exercise, supplement, Supplement+exercise, placebo, and control). A daily dose of 1000 mg (two 500 mg capsules) of Mulberry leaf extract was used 3 times a day for 2 months. The exercise and exercise + supplement groups practiced for 8 weeks in 3 sessions, each week for 90 minutes. The studied variables were measured 24 hours before and 48 hours after the intervention period.
Results: Galectin-3, apelin, and HbA1C levels in the post-test of the exercise, exercise+supplement, and supplement groups were significantly reduced compared to the pre-test (P<0.05). Also, the results of covariance analysis showed that the levels of galectin-3, apelin, and HbA1C in the exercise, exercise+supplement and supplement groups were significantly reduced compared to the placebo and control groups (P<0.05).
Conclusion: It seems that combined exercises and consumption of Mulberry leaf extract can be effective in reducing inflammatory biomarkers effective in the pathogenesis of diabetes in the elderly with type 2 diabetes. However, supplementing with combined exercise has the greatest effect on controlling these inflammatory markers.
Type of Study: Research |
Subject:
Exercise physiology
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