Volume 20, Number 4 (winter 2010)                   J Urmia Univ Med Sci 2010, 20(4): 307-312 | Back to browse issues page


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I Abdirad, M Bagheri, MD Omrani, H Norouzi Pakzad. POLYMORPHISMS OF IFN-Γ AND IL-10 GENES IN NORMAL POPULATION. J Urmia Univ Med Sci. 2010; 20 (4) :307-312
URL: http://umj.umsu.ac.ir/article-1-561-en.html

, isaabdirad@umsu.ac.ir
Abstract:   (8863 Views)

  I Abdi Rad, [1] PhD M Bagheri [2] , MSc MD Omrani [3] , PhD H Norouzi Pakzad [4] , MD

 

  Received: 18 Nov, 2008 Accepted: 21 Oct, 2009

 Abstract

 Backgrounds & Aims: Some of polymorphisms are located in the promoter regions or other regulatory sequences of cytokine genes and are associated with increased or decreased amount of cytokines production. The aim of this study was to determine the rate of polymorphisms of IFN-γ +874 and IL-10 -1082 in the normal population.

 Materials & Methods: 109 normal individuals were included in the study and genomic description was carried out using ASO-PCR method.

 Results: Allelic frequency of alleles A and T for IFN-γ +874 were 50.92% and 49.08% respectively, and the highest genotype frequency was for the genotype A/T (54.13%). Allelic frequency of A and G for IL-10 -1082 also were 50.92% and 49.08% respectively, and genotype A/G had the highest rate among different genotypes of IL-10 -1082 (96.33%).

 Conclusion: The alleles A and T of IFN-γ gene (+874) were in Hardy-Weinberg equilibrium, while it was not the case for A and G alleles of IL-10 gene (-1082).

 Keywords: Polymorphism, Interferon-γ +874, Interleukin-10 -1082

 

 Address: Department of Genetics, Motahhari Hospital, Urmia University of Medical Sciences, Urmia, Iran Tel: (+98 441) 2240166

 

 Email: isaabdirad@umsu.ac.ir

 

Source: UMJ 2010: 20(4): 338 ISSN: 1027-3727

  [1] Associate Professor of Medical Genetics, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author)

  [2] Instructor of Genetics, Urmia University of Medical Sciences, Urmia, Iran

  [3] Associate Professor of Genetics, Urmia University of Medical Sciences, Urmia, Iran

  [4] General Practitioner, Urmia University of Medical Sciences, Urmia, Iran

Full-Text [PDF 203 kb]   (1006 Downloads)    
Type of Study: Research | Subject: آناتومی
Received: 2010/03/31

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