Volume 32, Issue 4 (July 2021)
Studies in Medical Sciences 2021, 32(4): 262-272 |
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Assistant Professor Urmia University of Medical Sciences, School of Dentistry, Urmia, Iran (Corresponding Author) , Ehsankhashabi@gmail.com
Abstract: (1901 Views)
Background & Aims: Diabetes mellitus is a set of metabolic disorders caused by a set of factors that impair insulin synthesis or reduce sensitivity to it. The aim of this study was to evaluate the prevalence of intraoral lesions in patients with type 1 and type 2 diabetes mellitus.
Materials & Methods: In this descriptive study, patients referred to the internal ward of Imam Khomeini Hospital, and Alborz Dental Clinic in Urmia in 2020 were selected. Patients with controlled diabetes and HbA1C less than 7.5 and FBS less than 150 were included in the study. These patients were first asked about their history of diabetes, and their medication regimen by a final year dental student and oral and maxillofacial medicine specialist. Data were analyzed using Chi-square test and SPSS 16.0 software.
Results: Of 369 patients, 62.1% were male and 37.9% with a mean age of 50.4 years participated. Chi-square test showed that there was a significant difference between dry mouth and inflammation of the labia in women and men (001/0 > p). But there is no significant difference between dry mouth in subjects with type 1 diabetes and type 2 diabetes (p <0.05).
Conclusion: Due to the higher prevalence of oral inflammation and candidiasis in patients with type 2 diabetes, it is possible to link the pathophysiology of the disease with the prevalence of these manifestations. In other words patients with type 2 diabetes are among the high-risk groups with these lesions.
Materials & Methods: In this descriptive study, patients referred to the internal ward of Imam Khomeini Hospital, and Alborz Dental Clinic in Urmia in 2020 were selected. Patients with controlled diabetes and HbA1C less than 7.5 and FBS less than 150 were included in the study. These patients were first asked about their history of diabetes, and their medication regimen by a final year dental student and oral and maxillofacial medicine specialist. Data were analyzed using Chi-square test and SPSS 16.0 software.
Results: Of 369 patients, 62.1% were male and 37.9% with a mean age of 50.4 years participated. Chi-square test showed that there was a significant difference between dry mouth and inflammation of the labia in women and men (001/0 > p). But there is no significant difference between dry mouth in subjects with type 1 diabetes and type 2 diabetes (p <0.05).
Conclusion: Due to the higher prevalence of oral inflammation and candidiasis in patients with type 2 diabetes, it is possible to link the pathophysiology of the disease with the prevalence of these manifestations. In other words patients with type 2 diabetes are among the high-risk groups with these lesions.
Type of Study: Research |
Subject:
بیماریهای دهان ودندان
References
1. Rossi G, American Diabetes Association. Diagnosis and classification of diabetes mellitus. Recenti Prog Med 2010;101(7-8):274-6. [Google Scholar]
2. Falace D, Miller C, Rhodus NL. Phallase Dentistry managmanet of medical compromised patients 2018: 89, 93, 171. [Google Scholar]
3. Greenberg MS, Glick M. Burket's Oral medicine, diagnosis and treatment. 12th ed. Spain: BC Decker Inc.; 2015. P. 474 [Google Scholar]
4. Little JW, Falace D, Miller C, Rhodus NL. Phallase Dentistry managmanet of medical compromised patients 2018. P. 332. [Google Scholar]
5. Mohamed K, Yates J, Roberts A. Diabetes mellitus: considerations for the dental practitioner. Dent Update 2014;41(2):144-54. [DOI:10.12968/denu.2014.41.2.144] [PMID]
6. Contaldo M, Romano A, Mascitti M, Fiori F, Della Vella F, Serpico R, et al. Association between denture stomatitis, candida species and diabetic status. J Biol Regul Homeost Agents 2019;33(3 Suppl. 1):35-41. [Google Scholar]
7. Poskerová H, Linhartová PB, Hollá LI. Oral diseases in diabetic patients. Vnitr Lek 2019;65(4):314-20. [DOI:10.36290/vnl.2019.055] [PMID]
8. Saini R, Saini S, Sugandha R. Periodontal disease: The sixth complication of diabetes. J Family Community Med 2011;18(1):31. [DOI:10.4103/1319-1683.78636] [PMID] [PMCID]
9. Holzhausen M, Garcia DF, Pepato MT, Marcantonio E Jr. The influence of short-term diabetes mellitus and insulin therapy on alveolar bone loss in rats. J Periodontal Res 2004;39(3):188-93. [DOI:10.1111/j.1600-0765.2004.00723.x] [PMID]
10. Watanabe K. Periodontitis in diabetics: is collaboration between physicians and dentists needed?. Dis Mon 2011;57(4):206-13. [DOI:10.1016/j.disamonth.2011.03.007] [PMID] [PMCID]
11. Williams RC, Mahan CJ. Periodontal disease and diabetes in young adults. J Am Med Assoc 1990;172(8):776-8. [DOI:10.1001/jama.1960.03020080006003] [PMID]
12. Soares CD, Carlos R, Mota MVB, de Carvalho MGF, de Lima Morais TM, de Almeida OP, et al. Bilateral multiple oncocytic cysts of the parotid gland in type 2 diabetes patients. Histopathology 2020;76(4):613-24. [DOI:10.1111/his.14027] [PMID]
13. Nosratzehi T. Oral Lichen Planus: an Overview of Potential Risk Factors, Biomarkers and Treatments. Asian Pac J Cancer Prev 2018;19(5):1161-7. [PMID] [PMCID]
14. Kocher T, König J, Borgnakke WS, Pink C, Meisel P. Periodontal complications of hyperglycemia/diabetes mellitus: Epidemiologic complexity and clinical challenge. Periodontol 2000 2018;78(1):59-97. [DOI:10.1111/prd.12235] [PMID]
15. Silva MF, Barbosa KG, Pereira JV, Bento PM, Godoy GP, Gomes DQ. Prevalence of oral mucosal lesions among patients with diabetes mellitus types 1 and 2. An Bras Dermatol 2015;90(1):49-53. [DOI:10.1590/abd1806-4841.20153089] [PMID] [PMCID]
16. Rafatjou R, Razavi Z, Tayebi S, Khalili M, Farhadian M. Dental Health Status and Hygiene in Children and Adolescents with Type 1 Diabetes Mellitus. J Res Health Sci 2016;16(3):122-6. [Google Scholar]
17. de Souza Bastos A, Leite AR, Spin-Neto R, Nassar PO, Massucato EM, Orrico SR. Diabetes mellitus and oral mucosa alterations: prevalence and risk factors. Diabetes Res Clin Pract 2011;92(1):100-5. [DOI:10.1016/j.diabres.2011.01.011] [PMID]
18. Rabiei M, Mohtasham Amiri Z, Kalantari S, Hassannia H. Oral Soft Tissue Pathologies among Diabetic Patients in Rasht- 2005. J Shaheed Sadoughi Univ Med Sci 2007; 15 (3):46-52 [DOI:10.1111/j.1740-8709.2007.00065.x] [PMID] [PMCID]
19. de Souza Bastos A, Leite AR, Spin-Neto R, Nassar PO, Massucato EM, Orrico SR. Diabetes mellitus and oral mucosa alterations: prevalence and risk factors. Diabetes Res Clin Pract 2011;92(1):100-5. [DOI:10.1016/j.diabres.2011.01.011] [PMID]
20. Dryden M, Baguneid M, Eckmann C, Corman S, Stephens J, Solem C, et al. Pathophysiology and burden of infection in patients with diabetes mellitus and peripheral vascular disease: focus on skin and soft-tissue infections. Clin Microbiol Infect 2015;21 Suppl 2:S27-32. [DOI:10.1016/j.cmi.2015.03.024] [PMID]
21. Silva SY, Rueda LC, Márquez GA, López M, Smith DJ, Calderón et al. Double blind, randomized, placebo controlled clinical trial for the treatment of diabetic foot ulcers, using a nitric oxide releasing patch: PATHON. Trials 2007;8:26. [DOI:10.1186/1745-6215-8-26] [PMID] [PMCID]
22. Chan DML, Murphy M. Comparison of glycated haemoglobin and fasting blood glucose in the diagnosis of diabetes mellitus and pre-diabetes in a cohort of obese patients. J R Nav Med Serv 2017;103(1):39-43. [DOI:10.1136/jrnms-103-39]
23. Rohani B. Oral manifestations in patients with diabetes mellitus. World J Diabetes. 2019;10(9):485-9. [DOI:10.4239/wjd.v10.i9.485] [PMID] [PMCID]
24. Nagao T, Ikeda N, Fukano H, Hashimoto S, Shimozato K, Warnakulasuriya S. Incidence rates for oral leukoplakia and lichen planus in a Japanese population. J Oral Pathol Med 2005;34(9):532-9. [DOI:10.1111/j.1600-0714.2005.00349.x] [PMID]
25. Zomorodian K, Kavoosi F, Pishdad GR, Mehriar P, Ebrahimi H, Bandegani A, et al. Prevalence of oral Candida colonization in patients with diabetes mellitus. J Mycol Med 2016;26(2):103-10. [DOI:10.1016/j.mycmed.2015.12.008] [PMID]
26. Mozaffari HR, Sharifi R, Sadeghi M. Prevalence of Oral Lichen Planus in Diabetes Mellitus: a Meta-Analysis Study. Acta Inform Med 2016;24(6):390-3. [DOI:10.5455/aim.2016.24.390-393] [PMID] [PMCID]
27. Whitehead N, White H. Systematic review of randomised controlled trials of the effects of caffeine or caffeinated drinks on blood glucose concentrations and insulin sensitivity in people with diabetes mellitus. J Hum Nutr Diet 2013;26(2):111-25. [DOI:10.1111/jhn.12033] [PMID]
28. Bajaj S, Prasad S, Gupta A, Singh VB. Oral manifestations in type-2 diabetes and related complications. Indian J Endocrinol Metab 2012; 16(5): 777-9. [DOI:10.4103/2230-8210.100673] [PMID] [PMCID]
29. Javed F, Ahmed HB, Mehmood A, Saeed A, Al-Hezaimi K, Samaranayake LP. Association between glycemic status and oral Candida carriage in patients with prediabetes Oral Surg Oral Med Oral Pathol Oral Radiol 2014; 117(1): 53-8. [DOI:10.1016/j.oooo.2013.08.018] [PMID]
30. Arap A, Siqueira SR, Silva CB, Teixeira MJ, Siqueira JT. Trigeminal pain and quantitative sensory testing in painful peripheral diabetic neuropathy. Arch Oral Biol 2010;55(7):486-93. [DOI:10.1016/j.archoralbio.2010.03.021] [PMID]
31. González-Serrano J, Serrano J, López-Pintor RM, Paredes VM, Casañas E, Hernández G. Prevalence of Oral Mucosal Disorders in Diabetes Mellitus Patients Compared with a Control Group. J Diabetes Res 2016;2016:5048967. [DOI:10.1155/2016/5048967] [PMID] [PMCID]
32. Abu-Zahra R, Antos NJ, Kump T, Angelopoulou MV. Oral health of cystic fibrosis patients at a north american center: A pilot study. Med Oral Patol Oral Cir Bucal 2019;24(3):e379-84. [DOI:10.4317/medoral.22756] [PMID] [PMCID]
33. Verhulst MJL, Loos BG, Gerdes VEA, Teeuw WJ. Evaluating All Potential Oral Complications of Diabetes Mellitus. Front Endocrinol (Lausanne) 2019;10:56. [DOI:10.3389/fendo.2019.00056] [PMID] [PMCID]
34. Lalla E, Lamster IB. Assessment and management of patients with diabetes mellitus in the dental office. Dent Clin North Am 2012;56(4):819-29. [DOI:10.1016/j.cden.2012.07.008] [PMID]
35. Singh I, Singh P, Singh A, Singh T, Kour R. Diabetes an inducing factor for dental caries: A case control analysis in Jammu. J Int Soc Prev Community Dent 2016;6(2):125-9. [DOI:10.4103/2231-0762.178748] [PMID] [PMCID]
36. Laurent M, Gogly B, Tahmasebi F, Paillaud E. Les candidoses oropharyngées des personnes âgées [Oropharyngeal candidiasis in elderly patients]. Geriatr Psychol Neuropsychiatr Vieil 2011;9(1):21-8. French. [DOI:10.1684/pnv.2011.0259] [PMID]
37. Lewis MAO, Williams DW. Diagnosis and management of oral candidosis. Br Dent J 2017;223(9):675-81. [DOI:10.1038/sj.bdj.2017.886] [PMID]
38. Al-MAweri SA, Ismail NM, ISMAIL AR, Al-Ghashm A. Prevalence of oral mucosal lesions in patients with type 2 diabetes attending hospital universiti sains malaysia. Malays J Med Sci 2013;20(4):39-46. [PMID] [PMCID]
39. Kathiresan TS, Masthan KMK, Sarangarajan R, Babu NA, Kumar P. A Study of Diabetes Associated Oral Manifestations. J Pharm Bioallied Sci 2017;9(1):S211-6. [DOI:10.4103/jpbs.JPBS_157_17] [PMID] [PMCID]
40. Bastos AS, Leite AR, Spin-Neto R, Nassar PO, Massucato EM, Orrico SR. Diabetes mellitus and oral mucosa alterations: Prevalence and risk factors. Diabetes Res Clin Pract 2011;92(1):100-5. [DOI:10.1016/j.diabres.2011.01.011] [PMID]
41. Salehi M, Akha O, Mousavi J, Ziaee M, Molania T. Frequency of burning mouth and subjective xerostomia in patients with diabetes mellitus type 2. J Qazvin Univ Med Sci 2017; 21 (5):18-11. [Google Scholar]
42. Higa M. Clinical epidemiology of fungal infection in diabetes. Nihon Rinsho 2008;66(12):2239-44. Japanese. [Google Scholar]
43. Grushka M, Epstein JB, Gorsky M. Burning mouth syndrome. Am Fam Physician 2002; 65(4): 615-20. [Google Scholar]
44. Mohammadi F, Javaheri MR, Nekoeian S, Dehghan P. Identification of Candida species in the oral cavity of diabetic patients. Curr Med Mycol 2016;2(2):18-32. [DOI:10.18869/acadpub.cmm.2.2.4] [PMID] [PMCID]
45. Akherati M, Shafaei E, Salehiniya H, Abbaszadeh H. Comparison of the frequency of periodontal pathogenic species of diabetics and non-diabetics and its relation to periodontitis severity, glycemic control and body mass index. Clin Exp Dent Res 2021;22(4):331-8. [DOI:10.1002/cre2.453] [PMID] [PMCID]
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