Volume 31, Issue 9 (December 2020)                   Studies in Medical Sciences 2020, 31(9): 680-689 | Back to browse issues page

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URL: http://umj.umsu.ac.ir/article-1-5299-en.html
Assistant Professor, Department of physics, Faculty of Science, Urmia University, Urmia, Iran (Corresponding Author) , ak.abdi@urmia.ac.ir
Abstract:   (2563 Views)
Background & Aim: PET is a very useful and suitable imaging method in nuclear medicine. This method uses positrons with a special energy for imaging. The elements of the lanthanide are suitable for the decay of positrons with a specific energy for use in PET. Praseodymium-139 with a half-life of 4.5 hours is one of the useful elements in the group of lanthanides that can be used in PET. In this study, the 140Ce (p,2n)139Pr reaction to produce the useful radiopharmaceutical Praseodymium-139 was simulated by the TALYS code with four different models and also by the GEANT4 Monte Carlo code. The purpose of this simulation is to calculate the cross-sectional area of the reaction and the production efficiency of praseodymium-139 in the proton irradiated cerium-140 target.
Materials & Methods: The values of cross-section and production yield of Praseodymium-139 have been obtained through 140Ce(p,2n)139Pr reaction using TALYS and GEANT4 codes and the proton projectile range changes in the cerium-140 target were simulated using SRIM and GEANT4 codes.
Results: Proton range changes are shown using the SRIM and GEANT4 codes in the Cerium-140 target for different energies of the entrance protons. The range of protons in cerium-140 at 22 MeV energy was calculated to be 1610 and 1637.5 micrometers, respectively. Then the cross-sectional values simulated using TALYS and GEANT4 codes for different energies of the entrance protons were compared with the experimental data. At the energy of 5.22 MeV, the cross section of Praseodymium-139 has the maximum amount in the reaction 140Ce(p,2n)139Pr. The thickness of the production thickness was calculated from the target of cerium-140 for different proton energies. The cross-sectional values obtained in this energy using these two codes are 1150.7 and 1350.4 bar, respectively. Also, the amount of product yield in the energy of 22 MeV was calculated using these codes, 1832.1 and 1782.83 MBqµA-1h-1, respectively.
Discussion and conclusion: Comparison of the simulation results for the product of praseodymium-139 radiopharmaceuticals through the 140Ce(p,2n)139Pr  reaction using the TALYS code and the GEANT4 and SRIM Monte Carlo methods show that they are in good agreement with the experimental data. It is also possible to simulate the desired reaction using these codes without spending a lot of time and money and laboratory materials and before the production of radiopharmaceuticals, and to predict the values of production efficiency and the appropriate range of energy for the production of radiopharmaceuticals.
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Type of Study: Research | Subject: فیزیک پزشکی

1. Smith B. Nuclear Pharmacy.1th ed. London:Pharmaceutical Press; 2010. [URL]
2. Fricker SP. The therapeutic application of lanthanides.Chem. Soc. Rev 2006; 6: 524-33. [DOI:10.1039/b509608c] [PMID]
3. Zeisler SK, Becker DW. A new method for PETimaging of tumours: human serum albumin labeled with the long-lived 140Nd/139Pr in vivo radionuclide generator. Clin Positron Imaging 1999; 2: 324. [DOI:10.1016/S1095-0397(99)00084-9]
4. Kaczmarek MT, Zabiszak M, Nowak M, Jastrzab R.Lanthanides: Schiff base complex, applications in cancer diagnosis, therapy and antibacterial activity. Coord Chem Rev 2018; 370: 42-54. [DOI:10.1016/j.ccr.2018.05.012]
5. Teo RD, Termini J, Gray HB. Lanthanides:Applications in cancer diagnosis and therapy. J Med Chem 2016; 59: 6012-24. [DOI:10.1021/acs.jmedchem.5b01975] [PMID] [PMCID]
6. Steyn GF, Vermeulen C, Noritier FM, Szelecsenyi F,Kovacs Z. Production of no-carrier-added 139Pr via precursor decay in the proton bombardment of natPr. Nucl Instrum Methods Phys Res B 2006; 252: 149-59. [DOI:10.1016/j.nimb.2006.08.012]
7. Furukawa M. Excitation functions for proton-inducedreactions of 140Ce and 142Ce up to Ep=15 MeV. Nucl Phys A 1967; 67: 253-60. [DOI:10.1016/0375-9474(67)90232-1]
8. Zeisler K, Becker DW. A pellet method for themeasurement of excitation functions: Cross-section for 140Ce(p,2n)139Pr and 140Ce(p,3n)138mPr,Nucl Instrum Methods Phys Res B 2000; 160: 216-20. [DOI:10.1016/S0168-583X(99)00588-1]
9. Ziegler JF. SRIM & TRIM [Internet]. [cited 2020 Dec22]. Available from: http://www.srim.org/
10. Ziegler J, Andersen H. Helium stopping powers andranges in All element. NewYork: Pergamon; 1977.
11. Rostampour M, Aboudzadeh MR, Sadeghi M, HamidiS.Theoretical assessment of production routes for 63Zn bycyclotron. J Radioanal Nucl Chem Rostampour M, Aboudzadeh MR, Sadeghi M, HamidiS.Theoretical assessment of production routes for 63Zn bycyclotron. J Radioanal Nucl Chem 2016;309:677-84. [DOI:10.1007/s10967-015-4675-3]
12. Koning A, Hilaire S, Goriely S. TALYS1.95 Anuclear reaction program User manual. 1th ed. Netherlands: NRG; 2019. [URL]
13. Kakavand T, Mirzaii M, Eslami M, Karimi A. Nuclearmodel calculation and targetry recipe for production of 110mIn. Appl Radiat Isot 2015; 104: 60-6. [DOI:10.1016/j.apradiso.2015.06.022] [PMID]
14. Eslami M, Kakavand T. Simulation of the direct production of 99mTc at a small cyclotron. Nucl Instrum Methods Phys Res B 2014; 329: 18-21 [DOI:10.1016/j.nimb.2014.03.008]
15. Sharifian M, Sadeghi M, Alimohamadi M. Calculation of 89Y(p,x)86,88,89gZr,86g,87g,88gY,85gSr,and 84Rb reaction cross sections based on level density. Appl Radiat Isot 2019; 151: 25-9. [DOI:10.1016/j.apradiso.2019.05.004] [PMID]
16. Rostampour M, Sadeghi M, Aboudzadeh MR, Hamidi S, Hosseini SF. Validation of GEANT4 simulations for 62,63Zn yield estimation in proton induced reactions of natural copper. Nucl Instrum Methods Phys Res B 2017; 394: 141-4. [DOI:10.1016/j.nimb.2017.01.013]
17. Poignant F, Penfold S, Asp J, Takhar P, Jackson P. GEANT4 simulation of cyclotron radioisotope production in a solid target, Med Phys 2016; 32: 728-34. [DOI:10.1016/j.ejmp.2016.04.006] [PMID]
18. Cirrone GAP, Cuttone G, Dirose F, Pandola L, Romano F, Zhang Q. Validation of the Geant4 electromagnetic photon cross-section for elements and compounds. Nucl Instrum Methods Phys Res A 2010; 618: 315-22. [DOI:10.1016/j.nima.2010.02.112]
19. User Documentation | geant4.web.cern.ch [Internet]. [cited 2020 Dec 22]. Available from: https://geant4.web.cern.ch/support/user_documentation [URL]

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