Volume 31, Issue 3 (June 2020)                   Studies in Medical Sciences 2020, 31(3): 178-187 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Soleimany A, Hajizadeh R, Khadem vatani K, Seyyed-Mohammadzad M H, Khan ahmadi S. EVALUATION OF SERUM KLOTHO LEVEL IN PATIENTS WITH AND WITHOUT CORONARY ARTERY DISEASE. Studies in Medical Sciences 2020; 31 (3) :178-187
URL: http://umj.umsu.ac.ir/article-1-4769-en.html
Professor of cardiology, Department of Cardiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. (corresponding author) , khademvatan2002@yahoo.com
Abstract:   (2194 Views)

 Background and aims: Serum Klotho is suggested to have protective effect against cardiovascular diseases. Nitric oxide production and preventing of oxidative stress have been suggested as its possible mechanisms of action. In this study we aimed to evaluate the association between serum Klotho level and cardiovascular diseases.
Materials and Methods: According to coronary angiography results, 40 patients with normal coronary artery and 40 patients with coronary artery disease included in this study. Serum Klotho level and laboratory data were analyzed for each patient and the association between serum Klotho level and coronary artery disease was evaluated.
Results: Our results showed that Serum Klotho level in patients with 1 vessle, 2 vessle and 3 vessel disease was 2.16± 0.2, 2.2±0.13, 1.98±0.2 mIU/L respectively. (P value=0.02) The plasma Klotho concentration was significantly lower in patients with coronary artery disease.
Discussion: Serum Klotho level can be a useful marker for evaluation of patients with coronary artery disease.
 
Full-Text [PDF 2105 kb]   (599 Downloads)    
Type of Study: Research | Subject: قلب و عروق

References
1. Keskin M, Avsar S, Hayiroglu MI, Keskin T, Borklu EB, Kaya A, et al. Relation of the Number of Parity to Left Ventricular Diastolic Function in Pregnancy. Am J Cardiol 2017;120(1): 154-9. doi: 10.1016/j.amjcard.2017.03.244. [DOI:10.1016/j.amjcard.2017.03.244] [PMID]
2. sadeghi M, Ruhafaza H, Shirani SH, Akhavan Tabib A, Aghdak P, Hosseini SH. The Prevalence of coronary artery disease according to rose questionaire and ECG: Isfahan Healthy Heart program (IHHP). ARYA Atheroscler 2006;2(2): 70-4. [Google Scholar]
3. Ougro R, Kamide Y, Kokubo I, Shimaoka A, Congrains A, Horio T. Association of Carotid Atherosclerosis with genetic polymorphism of Klotho Gene in Patients with hypertension and in the General population. Circulation 2009;120: S620. [Google Scholar]
4. Rhee EJ, oh KW, Lee WY, Kim SY, jung CH, Kim BJ, et al. The differntial effect of age on the association of klotho gene polymorphisms with coronary artery disease. Metabolism 2006;55(10): 1344-51. [DOI:10.1016/j.metabol.2006.05.020] [PMID]
5. Imamura A, Okumura K, Ogawa Y, Murakami R, Torigoe M, Numaguchi Y, et al. Klotho gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese. Clin Chim Acta 2006;371(1-2): 66-70. [DOI:10.1016/j.cca.2006.02.021] [PMID]
6. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al. Mutation of the mouse klotho gene leads to a syndrome resembling aging. Nature 1997;309(6655): 45-51. [DOI:10.1038/36285] [PMID]
7. Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, et al. Suppression of aging in mice by the hormone klotho. Science 2005;309(5742): 1829-333. [DOI:10.1126/science.1112766] [PMID] [PMCID]
8. Yamazaki Y, Imura A, Urakawa I, Shimada T, Murakami J, Aono Y, et al. Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects. Biochem Biophys Res Commun 2010;398(3): 513-8. [DOI:10.1016/j.bbrc.2010.06.110] [PMID] [PMCID]
9. Kuroo M. Klotho and aging. Biochim Biophys Acta 2009;1790(10): 1049-58. [DOI:10.1016/j.bbagen.2009.02.005] [PMID] [PMCID]
10. Donate-Correa J, Mora-Fernandez C, Martinez-Sanz R, Muros-de-Fuentes M, Perez H, Meneses-Perez B, et al. Expression of FGF23/KLOTHO system in human vascular tissue. Int J Cardiol 2013;165(1): 179-83. [DOI:10.1016/j.ijcard.2011.08.850] [PMID]
11. Nakamura T, Saito Y, Ohyama Y, Masuda H, Sumino H, Kuro-o M, et al. Production of nitric oxide, but not prostacyclin, is reduced in klotho mice. Jpn J Pharmacol 2002;89(2): 149-56. [DOI:10.1254/jjp.89.149] [PMID]
12. Shimada T, Takeshita Y, Murohara T, Sasaki K, Egami K, Shintani S, et al. Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse. Circulation 2004;110(9): 1148-55 [DOI:10.1161/01.CIR.0000139854.74847.99] [PMID]
13. Navarro-Gonzalez JF, Donate-Correa J, Muros de Fuentes M, Perez-Hernandez H, Martinez-Sanz R, Mora-Fernandez C. Reduced Klotho is associated with the presence and severity of coronary artery disease. Heart 2014;100(1): 34-40. [DOI:10.1136/heartjnl-2013-304746] [PMID]
14. Shroff R, Shanahan CM. Klotho: an elixir of youth for the vasculature? J Am Soc Nephrol 2011;22(1): 5-7. [DOI:10.1681/ASN.2010111190] [PMID]
15. Moe SM. Klotho: a master regulator of cardiovascular disease? Circulation 2012;125: 2181-3. [DOI:10.1161/CIRCULATIONAHA.112.104828] [PMID]
16. Donate-Correa J, Mora-Fernandez C, Martinez-Sanz R, Muros-de-Fuentes M, Perez H, Meneses-Perez B, et al. Expression of FGF23/KLOTHO system in human vascular tissue. Int J Cardiol 2013;165(1): 179-83. [DOI:10.1016/j.ijcard.2011.08.850] [PMID]
17. MaekawaY, Ishikawa K, Yasuda O, Oguro R, Hanasaki H, Kida I, et al. Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation. Endocrine 2009;35(3): 341-6. [DOI:10.1007/s12020-009-9181-3] [PMID]
18. Wang Y, Kuro-o M, Sun Z. Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway. Aging Cell 2012;11(3): 410-7 [DOI:10.1111/j.1474-9726.2012.00796.x] [PMID] [PMCID]
19. Semba RD, Cappola AR, Sun K, Bandinelli S, Dalal M, Crasto C, et al. Plasma klotho and cardiovascular disease in adults. J Am Geriatr Soc 2011;59(9): 1596-601. [DOI:10.1111/j.1532-5415.2011.03558.x] [PMID] [PMCID]
20. Morita H, Takeda Y, Fujita S, Okamoto Y, Sakane K, Teramoto K, et al. Gender Specific Association between Serum Fibroblast Growth Factor 23/alpha-Klotho and Coronary Artery and Aortic Valve Calcification. J Atheroscler Thromb 2015;22(12): 1338-46. [DOI:10.5551/jat.30635] [PMID]
21. Jo SH, KIm SG, Choi YJ, Joo NR, Cho GY, Choi SR, et al. Klotho gene polymorphism is associated with coronary artery stenosis but not with coronary calcification in a Korean Population.Int Heart J 2009;50: 23-32. [DOI:10.1536/ihj.50.23] [PMID]
22. Arking DE, Becker DM, Yanek LR, Fallin D, Judge DP, Moy TF, et al. KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am J Hum Genet 2003;72(5): 1154-61. [DOI:10.1086/375035] [PMID] [PMCID]
23. Navarro-Gonzalez JF, Donate-Correa J, Muros de Fuentes M, Perez-Hernandez H, Martinez-Sanz R, Mora-Fernandez C. Reduced Klotho is associated with the presence and severity of coronary artery disease. Heart 2014;100(1): 34-40. doi: 10.1136/heartjnl-2013-304746. [DOI:10.1136/heartjnl-2013-304746] [PMID]
24. Shroff R, Shanahan CM. klotho: an elixir of youth for the vasculature? J Am Soc Nephrol 2011;22(1): 5-7. [DOI:10.1681/ASN.2010111190] [PMID]
25. Donate-Correa J, Muros de Fuentes M, Mora-Fernández C, Navarro-González JF. FGF23/Klotho axis: phosphorus, mineral metabolism and beyond. Cytokine Growth Factor Rev 2012;23 (1-2): 37-46. [DOI:10.1016/j.cytogfr.2012.01.004] [PMID]
26. Lim K, Lu TS, Molostvov G, Lee C, Lam FT, Zehnder D, et al. Vascular klotho deficiency potentiates the development of human artery calcification and mediates resistance to FGF-23. Circulation 2012;125: 2243-55. [DOI:10.1161/CIRCULATIONAHA.111.053405] [PMID]
27. Kendrick J, Chonchol M. The role of phosphorus in the development and progression of vascular calcification. Am J Kidney Dis 2011;58: 825-34. [DOI:10.1053/j.ajkd.2011.07.020] [PMID] [PMCID]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Studies in Medical Sciences

Designed & Developed by : Yektaweb