Volume 29, Issue 12 (March 2019)                   J Urmia Univ Med Sci 2019, 29(12): 896-903 | Back to browse issues page

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Associate Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran (Corresponding Author) , ziafalm@yahoo.com
Abstract:   (293 Views)
Background and objective: NGF-2 is oligodendrocyte progenitor cell which has neuroprotective functions. This study was designed to investigate and compare the effect of a 4-week voluntary training program on regular and complex running wheels on NGF-2 levels in healthy Wistar male rats.
Materials and methods: Thirty adult Wistar male rats were divided into 3 groups: voluntary training on regular running wheel, voluntary training on complex running wheel, and control. For measuring the NGF-2 levels in the brain, the ELISA test was used. One-way analysis of variance and Tuckey post-hoc tests were employed for comparing the intergroup differences. All the statistical analysis were conducted by SPSS software (version 20).
Results: Performing voluntary training programs on regular (p=0.03) and complex running wheels (p=0.001) resulted in significant changes in NGF-2 levels in the brain. There was also a significant difference between these two modes of training programs (p=0.05).
Conclusion: Based on the results, these 2 training protocols can be regarded as positive intervening factors for increasing oligodendrocytes in healthy rats, although the complex running wheel voluntary training has shown to be more promising.
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Type of Study: Research | Subject: Exercise physiology