Volume 29, Issue 4 (Monthly_Jul 2018)
Studies in Medical Sciences 2018, 29(4): 282-294 |
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tofighi A, mollazadeh H, Ghaderi Pakdel F. Effect of 12 weeks moderate intensity endurance training on BDNF levels in both sides of hippocampus and serum of male rats. Studies in Medical Sciences 2018; 29 (4) :282-294
URL: http://umj.umsu.ac.ir/article-1-4316-en.html
URL: http://umj.umsu.ac.ir/article-1-4316-en.html
Urmia University , Hosien.mollazadeh@gmail.com
Abstract: (4174 Views)
Background & Aims: In this study, we investigated the effect of moderate intensity endurance training on the amount of BDNF in the hippocampus and blood serum of male rats.The brain-derived nutritional agent (BDNF) is very important due to its important role in synaptic plasticity, memory and neuronal function, and is recognized as the most important factor in these sports-induced events.Hippocampus is one of the two neurogenic regions of the brain are very effective in exercising.Distribution of neurotrophins occurs in different regions of the brain and at higher levels in the Hippocampus
Materials & Methods: For this study, 20 male Wistar rats with 200 g weigh were prepared.Rats were divided into 2 groups of exercise and untreated (control) group.After adapting the animals to the training conditions, each exercise started with a warm-up period of 5 minutes at a speed of 8 m/ min.Then, 10 minutes later, as the first course at 10 m / min, and the main training for 40 minutes at a speed of 22 m / min, at the end of the animals.The speed of cooling was 8 m / min.And for animals, one hour of exercise per day and five days of training per week was applied.After completing the training period blood samples were taken from the heart of anesthetized animals and then perfused with physiological serum, finally the brain of the rats were operated under the laboratory conditions and the two sides of hippocampus were extracted.BDNF measurements were performed using ELISA kit and data analysis was done using student's t-test.
Results: The results of this study showed that 12 weeks of training had a significant effect on the brain-derived neurotrophic index of 20 rats in blood serum (p=0.013) and biphasic hippocampal tissue.(p=0.049)
Conclusion: The findings of this study, consistent with most studies, showed that BDNF in the training group there was a significant increase compared to the control group and showed that endurance exercise of moderate intensity could increase neuronal function in the hippocampus of the mouse, and also brain flexion modified by BDNF can be the basis for the positive effects of exercise on brain health.Nitric exercise also improves the moderate intensity of neuronal survival.Exercise can increase BDNF expression, increase efficacy and flexibility in pre-synaptic space and stimulant synapses.
Materials & Methods: For this study, 20 male Wistar rats with 200 g weigh were prepared.Rats were divided into 2 groups of exercise and untreated (control) group.After adapting the animals to the training conditions, each exercise started with a warm-up period of 5 minutes at a speed of 8 m/ min.Then, 10 minutes later, as the first course at 10 m / min, and the main training for 40 minutes at a speed of 22 m / min, at the end of the animals.The speed of cooling was 8 m / min.And for animals, one hour of exercise per day and five days of training per week was applied.After completing the training period blood samples were taken from the heart of anesthetized animals and then perfused with physiological serum, finally the brain of the rats were operated under the laboratory conditions and the two sides of hippocampus were extracted.BDNF measurements were performed using ELISA kit and data analysis was done using student's t-test.
Results: The results of this study showed that 12 weeks of training had a significant effect on the brain-derived neurotrophic index of 20 rats in blood serum (p=0.013) and biphasic hippocampal tissue.(p=0.049)
Conclusion: The findings of this study, consistent with most studies, showed that BDNF in the training group there was a significant increase compared to the control group and showed that endurance exercise of moderate intensity could increase neuronal function in the hippocampus of the mouse, and also brain flexion modified by BDNF can be the basis for the positive effects of exercise on brain health.Nitric exercise also improves the moderate intensity of neuronal survival.Exercise can increase BDNF expression, increase efficacy and flexibility in pre-synaptic space and stimulant synapses.
Keywords: Moderate intensity Endurance training, brain-derived Neurotrophic factor, Hippocampus male rats
Type of Study: Research |
Subject:
Exercise physiology
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