Background & Aims: Nowadays, in many developed and developing countries, the prevalence of obesity and type 2 diabetes has increased.  The prevalence of obesity among women may be higher than in men. Recently a new product from muscle and adipose tissue known as irisin has attracted the attention of researchers. Therefore, the aim of this study was to investigate the association between irisin and obesity follow of physical activity.
Materials & Methods: In this study 21 obese women (medium age: 37.99 ± 3.7 year, height: 1.55 ± 0.03 meter, BMI: 34±5 kg/m2) participated in the study.  They were randomly assigned to exercise groups (endurance (n: 10) and concurrent (n: 11)) for eight weeks, three sessions per week for 40 to 45 minutes. Irisin, fasting glucose, insulin, insulin resistance, and visceral mass ratio to body muscle were measured. The data were analyzed using two way ANOVA.
Results: After 8 weeks exercise training in both groups, irisin decreased significantly (P<0.05), but we did not find significant differences in fasting glucose, insulin, HOMA-IR and irisin between the groups (P>0.05).
Conclusion: Finally, there were no differences between groups of training. It can be hypothesis that the increase of irisin in obese people is one of the preventing ways against obesity's side effects.

Keywords: Endurance training, Concurrent training, Obesity, Irisin, Women

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