Volume 20, Number 2 (Summer 2009)                   J Urmia Univ Med Sci 2009, 20(2): 104-110 | Back to browse issues page


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FRACTAL STUDY ON NUCLEAR BOUNDARY OF CANCER CELLS IN URINARY SMEARS. J Urmia Univ Med Sci. 2009; 20 (2) :104-110
URL: http://umj.umsu.ac.ir/article-1-430-en.html

Abstract:   (8911 Views)

  Abstract

 Background & Aims: Cancer is a serious problem for human being. A necessary prerequisite for any therapeutic modality is early diagnosis. Fractal dimension measurement of nuclear boundary of cancer cells can be used as a feature extraction in the field of automated cancer diagnosis.

 Materials & Methods: 41 positive urine cytology and 33 negative ones were selected randomly. Digitalized images prepared using objective 100X and a digital video head preprocessed subsequently and the fractal dimension of nuclear boundaries was measured by a software.

 Results:Findings revealed a statistically significant difference between fractal dimensions of nuclear boundaries of cancerous versus non-cancerous in urinary smears. Selecting a proper cut off point (1.732 ± 0.006 in this study) can discriminate malignant and non-malignant epithelial cells in urinary smears.

 Conclusion: Based on diagnostic accuracy measures (sensitivity and specificity), probability of disease measures (predictive value of a positive and negative test results), and likelihood ratio of positive and negative tests, it seems fractal dimension of nuclear cell boundaries in urinary smears can be used as a feature extraction in the field of automated cancer diagnosis.

 

 Keywords:Automated cancer diagnosis, Screening machine design, Fractal dimension

 

  Address : Pathology Department, Imam Khomeini Hospital, Urmia, Iran Tel : (+98441) 3469931

 

  E-mail: ilkhanib@gmail.com

 

  Source: UMJ 2009: 20(2): 156 ISSN: 1027-3727


Full-Text [PDF 326 kb]   (992 Downloads)    
Type of Study: Research | Subject: آناتومی
Received: 2009/09/2

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