Volume 28, Issue 7 (Monthly_Oct 2017)                   J Urmia Univ Med Sci 2017, 28(7): 473-479 | Back to browse issues page

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Zolfaghari M, Golpasandi S, Golpasandi H. CHANGES FIBRINOLYSIS FACTORS OF OVERWEIGHT AND OBESE POSTMENOPAUSAL WOMEN IN RESPONSE TO AEROBIC TRAINING. J Urmia Univ Med Sci. 2017; 28 (7) :473-479
URL: http://umj.umsu.ac.ir/article-1-3889-en.html
student University of Urmia , shadi.golpasandi@yahoo.com
Abstract:   (619 Views)
Background & Aims: Obesity and menopause both increase the risk of cardiovascular diseases, associated with fibrinolysis capacity reduction. Aerobic training is associated with reduction risk of cardiovascular disease, but the role of aerobic training on tPA and PAI-1 as main regulators of fibrinolysis system in obese postmenopausal women is not understood. The aim of this study was to investigate the effects of aerobic training on fibrinolysis factors in overweight and obese postmenopausal women.
Materials & Methods: A number of twenty four overweight and obese postmenopausal women (age: 53.61±5.02 yrs, weight: 74.95±7.74kg and BMI: 30.56±3.43 kg/m2) were randomly divided into two groups including Aerobic Training (n=12) and Control (n=12). Aerobic training group was trained 3 sessions/wk for eight weeks at 60-75% of max reserve heart rate for 30-60 minutes. Blood samples were collected at baseline as well as 48 hrs after the last training session, followed by measuring tPA and PAI-1 plasma levels by ELISA. Dependent and independent T-tests have used to data analysis, the level of significance has been consider at P≤0/05.
Results: Data analysis showed, aerobic training significantly reduced the plasma level of PAI-1 (p≤0/05), however, there were no effects on tPA (P>0/05). Also, aerobic training reduced triglycerides, LDL and increased HDL (p≤0/05), but there were no effects on cholesterol tom (P>0/05).
Conclusion: Moderate-intensity aerobic training plays an important role in reducing PAI-1 and lipid profile in overweight and obese postmenopausal women, however, it seems it does not influence on variations of plasma tPA.
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Type of Study: Research | Subject: Exercise physiology

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