Volume 27, Number 5 (Monthly_Aug 2016)                   J Urmia Univ Med Sci 2016, 27(5): 393-401 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Afshar Yavari S, Rota S, Caglar K, Fidan I. EFFLUX PUMP INHIBITORS EFFECT ON THE MINIMUM INHIBITORY CONCENTRATION OF BENZALKONIUM CHLORIDE AND CHLORHEXIDINE IN ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZED INPATIENTS IN GAZI HOSPITAL, ANKARA. J Urmia Univ Med Sci. 2016; 27 (5) :393-401
URL: http://umj.umsu.ac.ir/article-1-3552-en.html

* , , , Assistant Professor of Laboratory Sciences Department of Laboratory Sciences, Faculty of Paramedical Sciences , Urmia University of Medical Sciences, Urmia, Iran , shafsharyavari@yahoo.com
Abstract:   (2242 Views)

Background & Aims: Today, increasing resistance to antibiotics causes serious problems for treatment of patients. The aim of this study was to determine the role of AdeABC efflux pump in the Benzalkonium chloride and Chlorhexidine MIC value with efflux pump inhibitors (1-1-naphthylmethyl-piperazine and phenyl-arginine-β-naphthylamide) in the A.baumanii strains isolated from intensive care unit.

Materials & Methods: This study was conducted on 50 isolates of Acinetobacter baumannii collected from ICU wards of Gazi hospital. The species identification was performed by standard laboratory methods. Benzalkonium chloride and Chlorhexidine MIC value were performed using microdilution method according to the clinical and laboratory standards institute (CLSI) guidelines. The activity of the efflux pump was evaluated using the efflux pump inhibitors.

Conclusions: The AdeABC efflux pump may play a role in decreasing Benzalkonium chloride and Chlorhexidine MIC value   in A. baumannii isolates.

SOURCE: URMIA MED J 2016: 27(5): 401 ISSN: 1027-3727

Full-Text [PDF 414 kb]   (782 Downloads)    
Type of Study: Research | Subject: میکروبیولوژی
Received: 2016/08/15 | Accepted: 2016/08/15 | Published: 2016/08/15

Add your comments about this article : Your username or email:
Write the security code in the box

Send email to the article author


© 2015 All Rights Reserved | URMIA MEDICAL JOURNAL

Designed & Developed by : Yektaweb