دوره 28، شماره 4 - ( 4-1396 )                   جلد 28 شماره 4 صفحات 245-251 | برگشت به فهرست نسخه ها


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norouzi N, Bonyadi M, Babaei E, Jabbarpour Bonyadi M H, Javadzadeh A. Association of CFI gene polymorphism with age related macular degeneration in Northwest of Iran. J Urmia Univ Med Sci. 2017; 28 (4) :245-251
URL: http://umj.umsu.ac.ir/article-1-3457-fa.html
norouzi neda، Bonyadi Mortaza، Babaei Esmaeil، Jabbarpour Bonyadi Mohammad Hossein، Javadzadeh AliReza. Association of CFI gene polymorphism with age related macular degeneration in Northwest of Iran. مجله پزشکی ارومیه. 1396; 28 (4) :245-251

URL: http://umj.umsu.ac.ir/article-1-3457-fa.html


Associate Professor Tabriz of University ، jabbarpour@tabrizu.ac.ir
چکیده:   (75 مشاهده)

Background & Aims: To investigate the association of CFI p.Gly119Arg polymorphism with Age-related macular degeneration (AMD).

Materials & Methods: In this case-control study, the association of p.Gly119Arg polymorphism in CFI gene was investigated in 65 patients suffering from AMD and150 healthy age, sex and ethnicity matched unrelated people as control group. Both of the case and control groups were originated from Northwest of Iran. Genotypes of both groups were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).

Results: Investigation of the association of p.Gly119Arg polymorphism in CFI gene with AMD showed that there are no statistically significant differences between patients and controls in genotype and allele frequencies of this polymorphism (P˃0/05).

Conclusion: Our result show that p.Gly119Arg polymorphism of the CFI gene is unrelated to the susceptibility to AMD in Northwest of Iran.

واژه‌های کلیدی: AMD، پلی مورفیسم، ژن CFI
متن کامل [PDF 239 kb]   (21 دریافت)    
نوع مطالعه: پژوهشي(توصیفی- تحلیلی) | موضوع مقاله: ژنتیک
دریافت: ۱۳۹۵/۴/۲ | پذیرش: ۱۳۹۵/۵/۱۱ | انتشار: ۱۳۹۶/۴/۲۵

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