Volume 28, Number 4 (Monthly_Jul 2017)                   J Urmia Univ Med Sci 2017, 28(4): 245-251 | Back to browse issues page


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norouzi N, Bonyadi M, Babaei E, Jabbarpour Bonyadi M H, Javadzadeh A. Association of CFI gene polymorphism with age related macular degeneration in Northwest of Iran. J Urmia Univ Med Sci. 2017; 28 (4) :245-251
URL: http://umj.umsu.ac.ir/article-1-3457-en.html

Associate Professor Tabriz of University , jabbarpour@tabrizu.ac.ir
Abstract:   (74 Views)

Background & Aims: To investigate the association of CFI p.Gly119Arg polymorphism with Age-related macular degeneration (AMD).

Materials & Methods: In this case-control study, the association of p.Gly119Arg polymorphism in CFI gene was investigated in 65 patients suffering from AMD and150 healthy age, sex and ethnicity matched unrelated people as control group. Both of the case and control groups were originated from Northwest of Iran. Genotypes of both groups were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).

Results: Investigation of the association of p.Gly119Arg polymorphism in CFI gene with AMD showed that there are no statistically significant differences between patients and controls in genotype and allele frequencies of this polymorphism (P˃0/05).

Conclusion: Our result show that p.Gly119Arg polymorphism of the CFI gene is unrelated to the susceptibility to AMD in Northwest of Iran.

Keywords: AMD, polymorphism, CFI gene
Full-Text [PDF 239 kb]   (21 Downloads)    
Type of Study: Research | Subject: ژنتیک
Received: 2016/06/22 | Accepted: 2016/08/1 | Published: 2017/07/16

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